Malta competed in the 2008 Summer Paralympics in Beijing, China from 6 to 17 September 2008. This was the island nation's seventh appearance at a Summer Paralympic Games since their debut in 1960, but their first since the 1984 Summer Paralympics 24 years earlier. Antonio Flores, a runner, was the only athlete to represent Malta at the Games, having qualified via the 2008 British Open Athletics Championships. At the Paralympics, Flores did not qualify for the final of the men's 100 metres T44 event after placing 11th overall in the competition and fifth in his heat during the heat stages; the fastest four participants in his heat advanced to the final.
Burkina Faso sent a delegation to the 2012 Summer Paralympics in London, United Kingdom, from 29 August to 9 September 2012. This was the country's fifth appearance at a Summer Paralympic Games. The Burkinese delegation to London consisted of two athletes, Lassane Gasbeogo and Kadidia Nikiema, who competed in wheelchair cycling at the Brands Hatch race circuit in Kent. Neither athlete won any medals in their respective events, with the best finish of Burkina Faso at these Paralympics coming from Nikiema in the women's road trial H3 race with a sixth-place result.
Togo competed at the 2016 Summer Paralympics held in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its debut appearance in the quadrennial event, although it had competed in the Summer Olympics nine times since the 1972 Games. The delegation consisted of a single lightweight powerlifter, Aliou Bawa, who qualified by being issued with a Bipartite Commission Invitation spot by the International Paralympic Committee. Bawa was the flag bearer for the opening ceremony. Bawa failed to record a mark in the men's 49 kg category after being unable to lift 113 kilograms of weight in his three attempts.
Somalia competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its debut appearance in the quadrennial event, although it had competed in the Summer Olympics nine times since the 1972 Games. The delegation consisted of a single middle-distance runner, Farhan Adawe, who qualified for the Games by meeting qualification standards in March 2016. He was chosen as the flag bearer for the opening ceremony and came ninth overall in his event, the men's 100 metres (T52), which led to his elimination from the Paralympics.
Senegal sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the fourth successive appearance for the nation in a Summer Paralympic Games after it debuted at the 2004 Summer Paralympics. Youssouphua Diouf, a javelin thrower, and shot put and discus thrower Daque Diop were the two athletes sent to Rio de Janeiro by Senegal. The delegation failed to win the country's first medal at the Summer Paralympics as its best performance in these Games was Diouf's seventh position in the men's javelin F56-57 event.
São Tomé and Príncipe competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its debut appearance in the quadrennial event, although it had competed in the Summer Olympics six times since the 1996 Games. The delegation consisted of a single short-distance runner Alex Anjos, who was chosen as São Tomé and Príncipe's flag bearer for the opening ceremony. Anjos was disqualified from the men's 100 metres (T47) for arriving late and failed to advance into the final of the men's 400 metres (T47) after failing to set a fast enough lap time.
Mozambique sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the country's second time competing at a Summer Paralympic Games after making its debut at the 2012 Summer Paralympics. Mozambique was represented by one athlete, Edmilisa Governo, a short-distance sprinter. She competed in two events, the women's 100 metres T12 competition and the women's 400 metres T12. Governo reached the semi-finals of the women's 100 metres T12 and took Mozambique's first Paralympic Games medal in the women's 400 metres T12 by placing third in the final of the competition.
Mauritius sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the fifth time the country had taken part in a Paralympic Games after its debut at the 1996 Summer Paralympics. The Mauritian delegation to Rio de Janeiro consisted of two athletes: wheelchair racer Brandy Perrine and short-distance swimmer Scody Victor. The nation's best result was tenth overall by Perrine in the women's 100 metres T54 event as both competitors did not progress to the final in their respective competitions.
Lesotho sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the fifth time the country competed in the Summer Paralympic Games after it made its debut sixteen years prior at the 2000 Sydney Paralympics. The delegation to Rio de Janeiro consisted of two athletes: sprinter Sello Mothebe and discus thrower Litsitso Khotele. Mothebe originally came third in the heats of the men's 200 metres T12 and the men's 400 metres T12 events but he was retroactively disqualified for testing positive for a banned substance. Khotele ranked tenth in the women's discus throw F43–44 competition with a throw of 19.91 metres.
Nicaragua sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the Central American country's third appearance at the Summer Paralympic Games, having made its debut twelve years earlier at the 2004 Summer Paralympics. They were represented by three athletes, sprinter Jennifer Osejo, middle-distance runner and sprinter Gabriel Cuadra Holmann and powerlifter Fernando Acevedo, who all qualified for the games by achieving the minimum qualifying standard in international competition. Neither Holmann or Osejo claimed a medal in their respective events and Acevado finished fifth in the men's −72kg powerlifting class.
Aruba competed in the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its debut appearance in the quadrennial event, although it had competed in the Summer Olympics eight times since the 1988 Games. The delegation consisted of a single short-distance swimmer, Jesus De Marchena Acevedo, who qualified for the Games by using a wildcard. He was chosen as the flag bearer for the opening ceremony and was disqualified from the first discipline he took part in, men's 50 metres freestyle (S7), for arriving late but later placed last overall in the 100 metres freestyle (S7).
Haiti sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its third appearance at the quadrennial event and its delegation consisted of one shot put thrower Jean Indris Santerre, who qualified for the games by being issued a wild card from the International Paralympic Committee after being unable to qualify on merit. He was chosen as the flag bearer for the opening ceremony. Santerre did not start the final of the men's F57 shot put competition held at the Maracanã Stadium on 17 September for unknown reasons.
Tajikistan sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the fourth consecutive appearance of the country at the Paralympic Games after it made its debut twelve years prior at the 2004 Summer Paralympics. Tajikistan was represented by a single athlete in Rio de Janeiro: sprinter Romikhudo Dodikhudoev. He finished 14th overall in both of the men's 400 metres T47 and the men's 100 metres T47 and these performances meant he did not qualify for the final of both competitions.
Pakistan competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its seventh appearance in the quadrennial event. The delegation consisted of the long jump competitor Haider Ali who qualified for the Games by meeting the required standards for the men's long jump T37 in a March 2016 event held in Dubai. On 13 September, he won Pakistan's second Paralympic medal with a mark of 6.28 metres in his event, placing him third.
Nepal sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the fourth time the nation had taken part in a Paralympic Games following its first appearance at the 2004 Summer Paralympics. Nepal was represented by two athletes in Rio de Janeiro: sprinter Bikram Rana and short-distance swimmer Laxmi Kunwar, who both qualified for the Paralympics by using wild card spots for their respective sports. Neither athlete advanced beyond the first round of their respective events as they both finished 17th overall in their competitions.
Moldova sent a delegation to participate at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the Eastern European's country sixth appearance in the Summer Paralympic Games since their debut twenty years prior at the 1996 Summer Paralympics. Moldova sent three athletes to these Games, shot put thrower Oxana Spataur, powerlifter Larisa Marinenkova and short-distance swimmer Alexandr Covaliov. Spataur qualified on merit and Covaliov and Marienkova were invited by the Bipartite Commission. Neither Spataur or Covaliov advanced out of the heats of their events and Marienkova finished seventh in the women's 73kg powerlifting category.
Montenegro sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the nation's third time competing at a Paralympic Games since it became independent from its federation with Serbia in June 2006. Montenegro was represented by two athletes in Rio de Janeiro: shot putter and discus thrower Marijana Goranović and short-distance swimmer Ilija Tadić. Goranović competed in two events in field and her best finish was in the women's shot put F41 competition, where she came eighth. Tadić took part in two swimming events and his best performance was in the men's 50 metre freestyle S9 tournament, where he placed 14th overall and did not advance to the final.
The Faroe Islands sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. They sent one participant, Krista Mørkøre, who participated in three events in swimming. Her top finish was 10th in women's 400 m freestyle S10, and she did not qualify for the finals of any of her three events.
Cyprus sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the island country's eighth consecutive appearance in a Summer Paralympiad having made its debut at the 1988 Summer Paralympics. The Cypriot delegation to Rio de Janeiro consisted of two athletes: sprinter Antonis Aresti and short-distance swimmer Karolina Pelendritou. Aresti placed sixth overall in the men's 400 metres T47 event and Pelendritou came fourth in the 100 metres breaststroke SB13 competition after losing the bronze medal by 20 cm (7.9 in) in the final.
Malawi competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its debut appearance in the quadrennial event, although it had competed in the Summer Olympics ten times since the 1972 Games. The delegation consisted of a single middle-distance runner, Taonere Banda, who qualified for the games by using a wildcard. She was chosen as the flag bearer for the opening ceremony and was disqualified from her event, the 1500 metres (T13), for moving outside her lane during her heat.
