Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology.
The Max Planck Institute for Biophysical Chemistry, also known as the Karl-Friedrich Bonhoeffer Institute, was a research institute of the Max Planck Society, located in Göttingen, Germany. On January 1, 2022, the institute merged with the Max Planck Institute for Experimental Medicine in Göttingen to form the Max Planck Institute for Multidisciplinary Sciences.
Martin Karplus is an Austrian and American theoretical chemist. He is the Director of the Biophysical Chemistry Laboratory, a joint laboratory between the French National Center for Scientific Research and the University of Strasbourg, France. He is also the Theodore William Richards Professor of Chemistry, emeritus at Harvard University. Karplus received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Arieh Warshel, for "the development of multiscale models for complex chemical systems".
William Esco Moerner, also known as W. E. Moerner, is an American physical chemist and chemical physicist with current work in the biophysics and imaging of single molecules. He is credited with achieving the first optical detection and spectroscopy of a single molecule in condensed phases, along with his postdoc, Lothar Kador. Optical study of single molecules has subsequently become a widely used single-molecule experiment in chemistry, physics and biology. In 2014, he was awarded the Nobel Prize in Chemistry.
Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology. It seeks to understand biomolecular systems and explain biological function in terms of molecular structure, structural organization, and dynamic behaviour at various levels of complexity. This discipline covers topics such as the measurement of molecular forces, molecular associations, allosteric interactions, Brownian motion, and cable theory. Additional areas of study can be found on Outline of Biophysics. The discipline has required development of specialized equipment and procedures capable of imaging and manipulating minute living structures, as well as novel experimental approaches.
The Max Planck Institute for Medical Research in Heidelberg, Germany, is a facility of the Max Planck Society for basic medical research. Since its foundation, six Nobel Prize laureates worked at the Institute: Otto Fritz Meyerhof (Physiology), Richard Kuhn (Chemistry), Walther Bothe (Physics), André Michel Lwoff, Rudolf Mößbauer (Physics), Bert Sakmann and Stefan W. Hell (Chemistry).
Arieh Warshel is an Israeli-American biochemist and biophysicist. He is a pioneer in computational studies on functional properties of biological molecules, Distinguished Professor of Chemistry and Biochemistry, and holds the Dana and David Dornsife Chair in Chemistry at the University of Southern California. He received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Martin Karplus for "the development of multiscale models for complex chemical systems".
The following outline is provided as an overview of and topical guide to biophysics:
Peter Guy Wolynes is an American theoretical chemist and physicist. Since 2011 he has been a Bullard-Welch Foundation Professor of Science and professor of chemistry at Rice University. He is widely recognized for his significant contributions to the theories of protein folding, glasses, and gene networks. Previously he was James R. Eiszner Professor at the University of Illinois at Urbana-Champaign, and the Francis H.C. Crick Chair of Physical Sciences at the University of California, San Diego.
Taekjip Ha is a South Korean-born American biophysicist who is currently a Bloomberg Distinguished Professor of Biophysics and Biomedical Engineering at Johns Hopkins University. He was previously the Gutgsell Professor of Physics, at University of Illinois at Urbana-Champaign where he was the principal investigator of Single Molecule Nanometry group. He is also a Howard Hughes Medical Institute investigator.
Sharon Hammes-Schiffer is a physical chemist who has contributed to theoretical and computational chemistry. She is currently the A. Barton Hepburn Professor of Chemistry at Princeton University. She has served as senior editor and deputy editor of the Journal of Physical Chemistry and advisory editor for Theoretical Chemistry Accounts. She is the editor-in-chief of Chemical Reviews.
Klaus Schulten was a German-American computational biophysicist and the Swanlund Professor of Physics at the University of Illinois at Urbana-Champaign. Schulten used supercomputing techniques to apply theoretical physics to the fields of biomedicine and bioengineering and dynamically model living systems. His mathematical, theoretical, and technological innovations led to key discoveries about the motion of biological cells, sensory processes in vision, animal navigation, light energy harvesting in photosynthesis, and learning in neural networks.
Nancy Makri is the Edward William and Jane Marr Gutgsell Endowed Professor of Chemistry and Physics at the University of Illinois Urbana–Champaign, where she is the principal investigator of the Makri Research Group for the theoretical understanding of condensed phase quantum dynamics. She studies theoretical quantum dynamics of polyatomic systems, and has developed methods for long-time numerical path integral simulations of quantum dissipative systems.
Cho Minhaeng is a South Korean scientist in researching physical chemistry, spectroscopy, and microscopy. He was director of the National Creative Research Initiative Center for Coherent Multidimensional Spectroscopy and is founding director of the Center for Molecular Spectroscopy and Dynamics in the Institute for Basic Science (IBS), located in Korea University.
Albert Stolow is a Canadian physicist. He is the Canada Research Chair in Molecular Photonics, full professor of chemistry & biomolecular sciences and of physics, and a member of the Ottawa Institute for Systems Biology at the University of Ottawa. He is the founder and an ongoing member of the Molecular Photonics Group at the National Research Council of Canada. He is adjunct professor of Chemistry and of Physics at Queen's University in Kingston, and a Graduate Faculty Scholar in the department of physics, University of Central Florida and a Fellow of the Max-Planck-uOttawa Centre for Extreme and Quantum Photonics. In 2008, he was elected a Fellow in the American Physical Society, nominated by its Division of Chemical Physics in 2008, for contributions to ultrafast laser science as applied to molecular physics, including time-resolved studies of non-adiabatic dynamics in excited molecules, non-perturbative quantum control of molecular dynamics, and dynamics of polyatomic molecules in strong laser fields. In 2008, Stolow won the Keith Laidler Award of the Canadian Society for Chemistry, for a distinguished contribution to the field of physical chemistry, recognizing early career achievement. In 2009, he was elected a Fellow of the Optical Society of America for the application of ultrafast optical techniques to molecular dynamics and control, in particular, studies of molecules in strong laser fields and the development of new methods of optical quantum control. In 2013, he was awarded the Queen Elizabeth II Diamond Jubilee Medal (Canada). In 2017, Stolow was awarded the Earle K. Plyler Prize for Molecular Spectroscopy and Dynamics of the American Physical Society for the development of methods for probing and controlling ultrafast dynamics in polyatomic molecules, including time-resolved photoelectron spectroscopy and imaging, strong field molecular ionization, and dynamic Stark quantum control. In 2018, Stolow was awarded the John C. Polanyi Award of the Canadian Society for Chemistry “for excellence by a scientist carrying out research in Canada in physical, theoretical or computational chemistry or chemical physics”. In 2020, he became Chair of the Division of Chemical Physics of the American Physical Society. His group's research interests include ultrafast molecular dynamics and quantum control, time-resolved photoelectron spectroscopy and imaging, strong field & attosecond physics of polyatomic molecules, and coherent non-linear optical microscopy of live cells/tissues, materials and geological samples. In 2020, Stolow launched a major new high power ultrafast laser facility at the University of Ottawa producing high energy, phase-controlled few-cycle pulses of 2 micron wavelength at 10 kHz repetition rate. These are used for High Harmonic Generation to produce bright ultrafast Soft X-ray pulses for a new Ultrafast Xray Science Laboratory.
Laura B. Eisenstein (1942–1985) was a professor in the physics department at the University of Illinois until her early death. Eisenstein was known for her contributions to the understanding of light-energy transduction mechanisms in biological molecules and their higher order assemblies. She was an experimentalist and spectroscopist who was particularly well known for her contributions applying the techniques of x-ray absorption spectroscopy and time-resolved resonance Raman spectroscopy to the study of biomolecules. These studies indicated that phenomena such as quantum-mechanical tunnelling can be successfully investigated even in soft-matter systems like proteins.
Barry H. Honig is an American biochemist, molecular biophysicist, and computational biophysicist, who develops theoretical methods and computer software for "analyzing the structure and function of biological macromolecules."
Gerd Ulrich "Uli" Nienhaus is a German physicist who is a professor and director of the Institute of Applied Physics, Karlsruhe Institute of Technology (KIT). At the KIT, he is also affiliated with the Institute of Nanotechnology, Institute of Biological and Chemical Systems, and Institute of Physical Chemistry, and he is an adjunct professor at the University of Illinois at Urbana-Champaign.
Enrico Gratton is an Italian-American biophysicist. His research is focused on the field of biophotonics and fluorescence spectroscopy.
