Mauro Ferrari

Mauro Ferrari
Born	(1959-07-07) 7 July 1959 (age 66) Padua, Italy
Alma mater	University of California Berkeley MS, PhD (Mechanical Engineering) University of Padua, Italy Dottore, Mathematics)
Known for	Nanomedicine Cancer Therapeutics Nanofluidics Drug delivery Biomedical microtechnology Bioethics
Spouse	Paola Ferrari ​ (m. 1995)​
Children	five
Awards	National Academy of Sciences Italy National Academy of Sciences Europe Blaise Pascal Medal in Biomedical Engineering (2012) Department of Defense Innovator Award (2009-2014) Fellow, American Association for the Advancement of Science (2009) Aurel Stodola Medal (2005)
Scientific career
Fields	Nanomedicine
Institutions	Houston Methodist University of Texas National Cancer Institute Ohio State University University of California Berkeley
Website	www.houstonmethodist.org/research/our-faculty/labs/ferrari-lab/

Mauro Ferrari (born 7 July 1959) is a nanoscientist ^{[1] [2]} and leader in the field of nanomedicine. He served as special expert on nanotechnology for the National Cancer Institute (2003-2005) and was instrumental in establishing the Alliance for Nanotechnology in Cancer in 2004. ^{[3] [4] [5] [6] [7]}

Ferrari held tenured academic positions at UC Berkeley, Ohio State University, MD Anderson Cancer Center, and the University of Texas Health Science Center. ^[8]

Early life and education

Ferrari was born in Padua, Italy in 1959. He spent his early years in Udine and Florence before attending the University of Padova and earning his Laurea (PhD) in Mathematics in 1985. He moved to Berkeley, California where he earned a master's degree and a doctorate in mechanical engineering from the University of California Berkeley. ^{[9] [10] [11]}

Career

Professor of Engineering

Ferrari became an associate professor of engineering at Berkeley, then moved to the Ohio State University as professor of bioengineering, internal medicine, and mechanical engineering. ^[12] He studied medicine at the Ohio State University concurrent with his faculty appointment from 2002-2004. ^[13]

Cancer research

He moved to the MD Anderson Cancer Center and University of Texas Health Science Center at Houston, TX to become the chair of the department of nanomedicine and biomedical engineering, and then in 2010 accepted the position of president and CEO of the Houston Methodist Research Institute in Houston, TX. ^[12] Ferrari was appointed as Chief Commercialization Officer of Houston Methodist in 2018, and retired in 2019.^{[ citation needed ]}

ERC President (2020)

In 2019, the European Commission announced the appointment of Ferrari as the next President of the European Research Council (ERC), succeeding Jean-Pierre Bourguignon; he was selected by a search committee chaired by Mario Monti. ^{[14] [15]} On 1 January 2020, Ferrari assumed the position of president of the European Research Council (ERC). ^[14]

Ferrari resigned in 7 April 2020, citing his disappointment at the lack of coordinated EU action to address the COVID-19 pandemic and expressing frustration over opposition to his efforts to launch a scientific program to combat the virus. ^{[16] [17] [18]} Ferrari was not alone in his criticism of the EU response to COVID-19. ^[19]

The ERC countered that calling for specific research was contrary to their mandate. According to Science Magazine, "ERC, set up to reward bottom-up basic research ideas, does not designate money for specific research areas....Other EU organ[ization]s can and do pay for research in particular fields, including COVID-19, but ERC is designed to protect science from politics. Ferrari writes that 'the expected burden of death, suffering, societal transformation, and economic devastation' of the pandemic justifies breaking this rule." ^{[20] [18]}

The ERC responded on 8 April 2020: "...we regret Professor Ferrari's statement, which at best is economical with the truth." ^[21] The ERC stated that on 27 March 2020, following a no-confidence vote by the ERC's Scientific Council, they "requested that Mauro Ferrari resign from his position as ERC’s President". They cited poor conduct in office, exploiting the position to further his own projects, and for consistently failing to represent the interests of the ERC. ^[22]

Ferrari disputed the ERC claims of his failing to meet his obligations and their accusations of inappropriate outside involvements. ^{[20] [23] [24] [25]} In the months following Ferrari's resignation, the EU itself debated whether some funding of the ERC should include some focused research on COVID-19; which is what Ferrari advocated and the ERC adamantly opposed. ^[26]

Other activities

Corporate boards

• AMBER, Member of the Scientific Advisory Board ^[27]
• Arrowhead Pharmaceuticals, Member of the Board of Directors ^[28] (2010–present)
• Dead Sea Research Institute, President of the int'l board of governors ^[29]
• Leonardo Biosystems, Member of the Board of Directors
• NanoMedical Systems, Member of the Board of Directors

Non-profit organizations

• Member of the Engineering Leadership Board, Cullen College of Engineering, University of Houston ^[30]

Research interests

Ferrari's research uses nanotechnology, microtechnology, physical sciences, mathematics, biomechanics, and material sciences to develop new technologies for health care applications like drug delivery and cancer therapeutics. ^{[1] [31]} He leads a physical sciences in oncology center, one of a network of centers sponsored by the National Institutes of Health National Cancer Center. The research of this center focuses on understanding the physical and biomechanical biological barriers that reduce the efficacy of cancer therapeutics. ^[32] He developed a new drug called iNPG-pDox, composed of silicon nanoparticles loaded with polymeric doxorubicin, that had better results at lower doses in animal models compared to standard doxorubicin chemotherapy for metastatic breast cancer. ^{[33] [2]}

Published works

Ferrari has produced more than 350 publications, including seven books and 41 issued patents in the US and Europe. In June 2020, Ferrari and his lab colleagues had a publication retracted from Science Advances Journal due to various image duplications suggesting possible scientific misconduct. ^[34]

Books

• Ferrari M, Granik VT, Imam A, Nadeau J, editors. Advances in Doublet Mechanics. Lecture Notes in Physics, New Series M: Monographs, vol. m 45. Berlin, Heidelberg, New York: Springer Verlag; 1997. ISBN   978-3-540-49636-6
• Ferrari M. Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications. SPIE, The International Society for Optical Engineering; 1999 Jan. ISBN   9780819423894
• Lee A, Lee J, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol I: Biological and Biomedical Nanotechnology. Springer. 2006. ISBN   978-0-387-25842-3
• Ozkan M, Heller M, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol II: Micro/Nanotechnologies for Genomics and Proteomics. Springer. 2006. ISBN   978-0387255644
• Desai T, Bhatia SN, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol III: Therapeutic Micro/Nanotechnologies. Springer. 2006. ISBN   978-1850758600
• Bashir R, Werely S, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol IV: Biomolecular Sensing, Processing, and Analysis. Springer. 2006. ISBN   978-0387255668
• Cristini V, Ferrari M, Decuzzi P, editors. Nanoparticulate Delivery to Cancerous Lesions: Advances in Mathematical Modeling. Ferrari M, series editor. Fundamental Biomedical Technologies. Vol. 2. Springer. April 2010. ISBN   978-0387290850

Journal articles

• Xu R, et al. (2016). "An injectable nanoparticle generator enhances delivery of cancer therapeutics". Nat Biotechnol. 34 (4): 414–8. doi:10.1038/nbt.3506. PMC   5070674 . PMID   26974511.
• Blanco E, et al. (2014). "Co-localized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR". Molecular Therapy. 22 (7): 1310–9. doi:10.1038/mt.2014.27. PMC   4088997 . PMID   24569835.
• Dave B, et al. (2014). "Targeting RPL39 and MLF2 reduce tumor initiation and metastasis in breast cancer by inhibiting nitric oxide syn". Proceedings of the National Academy of Sciences. 111 (24): 8838–43. doi: 10.1073/pnas.1320769111 . PMC   4066479 . PMID   24876273.
• Chen X, et al. (2014). "XBP1 promotes triple negative breast cancer by controlling the HIF1α pathway". Nature. 508 (7494): 103–107. Bibcode:2014Natur.508..103C. doi:10.1038/nature13119. PMC   4105133 . PMID   24670641.
• Parodi A, et al. (2013). "Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions". Nature Nanotechnology. 8 (1): 61–68. Bibcode:2013NatNa...8...61P. doi:10.1038/nnano.2012.212. PMC   3751189 . PMID   23241654.
• Hall R, Sun T, Ferrari M (2012). "A portrait of nanomedicine and its bioethical implications". Journal of Law, Medicine & Ethics. 40 (4): 763–779. doi:10.1111/j.1748-720X.2012.00705.x. PMID   23289679. S2CID   16678752.
• Michor F, Liphardt J, Ferrari M, Widom J (2011). "What does physics have to do with cancer?". Nature Reviews Cancer. 11 (9): 657–670. doi:10.1038/nrc3092. PMC   3711102 . PMID   21850037.
• Ananta JS, et al. (2010). "Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast". Nature Nanotechnology. 5 (11): 815–821. Bibcode:2010NatNa...5..815A. doi:10.1038/nnano.2010.203. PMC   2974055 . PMID   20972435.
• Ferrari M (2010). "Vectoring siRNA therapeutics into the clinic". Nature Reviews Clinical Oncology. 7 (9): 485–6. doi:10.1038/nrclinonc.2010.131. PMID   20798696. S2CID   41070268.
• Evans J (2009). "Five big ideas for nanotechnology". Nature Medicine. 15 (4): 348. doi: 10.1038/nm0409-348 . PMID   19349991. S2CID   205377524.
• Ferrari M (2009). "Straight talk with Mauro Ferrari". Nature Medicine. 15 (7): 716–7. doi:10.1038/nm0709-716. PMID   19584847. S2CID   205380426.
• Gewin, V (2009). "Big opportunities in a small world". Nature. 460 (7254): 540–1. doi:10.1038/nj7254-540a. PMID   19637403.
• Ferrari M (2008). "Nanogeometry: Beyond Drug Delivery". Nature Nanotechnology. 3 (3): 131–132. Bibcode:2008NatNa...3..131F. doi:10.1038/nnano.2008.46. PMID   18654480.
• Sanhai W, Sakamoto J, Canady R, Ferrari M (2008). "Seven Challenges for Nanomedicine". Nature Nanotechnology. 3 (5): 242–244. Bibcode:2008NatNa...3..242S. doi:10.1038/nnano.2008.114. PMID   18654511.
• Cheng M, et al. (2006). "Nanotechnologies for Biomolecular Detection and Medical Diagnostics". Current Opinion in Chemical Biology. 10 (1): 11–19. doi:10.1016/j.cbpa.2006.01.006. PMID   16418011.
• Sanga S, Sinek J, Frieboes H, Ferrari M, Fruehauf J, Christini V (2006). "Mathematical Modeling of Cancer Progression and Response to Chemotherapy". Expert Review of Anticancer Therapy. 6 (10): 1361–1376. doi:10.1586/14737140.6.10.1361. PMID   17069522. S2CID   20253749.
• Decuzzi P, Lee S, Bhushan B, Ferrari M (2005). "A Theoretical Model for the Margination of Particles within Blood Vessels". Annals of Biomedical Engineering. 33 (2): 179–190. doi:10.1007/s10439-005-8976-5. PMID   15771271. S2CID   1705344.
• Ferrari M (2005). "Cancer nanotechnology: opportunities and challenges". Nature Reviews Cancer. 5 (3): 161–171. doi:10.1038/nrc1566. PMID   15738981. S2CID   340845.
• Liotta L, Ferrari M, and Petricoin E (2003). "Clinical proteomics: Written in blood". Nature. 425 (6961): 905. Bibcode:2003Natur.425..905L. doi: 10.1038/425905a . PMID   14586448. S2CID   34755301.

Patents

• WOapplication 201517777,Fine D, Grattoni A, Ferrari M, Liu X, Goodall R, Hosali S,"Therapeutic microdevices and methods of making and using same",published 2015 
• USpatent 8926994,Ferrari M, Serda R, Meraz IM, Gu J, Xia X, Shen H, Sun T,"Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity",published 2015 
• USpatent 8685755,Ferrari M, Tasciotti E, Liu X, Bouamrani A, Hu Y,"Combinational multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules",published 2014 
• USpatent 8753897,Ferrari M, Cheng MM-C, Cuda G, Gaspari M, Geho D, Liotta L, Petricoin E, Robertson F, Terracciano R,"Nanoporous substrates for the [sic] analytical methods",published 2014 
• USpatent 8920625,Ferrari M, Liu X, Cheng MC,"Electrochemical method of making porous particles using a constant current density",published 2014 
• USpatent 8361508,Decuzzi P, Ferrari M,"Endocytotic Particles",published 2013 
• USpatent 8480637,Ferrari M, Liu X, Grattoni, Fine D, Goodall R, Hosali S, Medema R, Hudson L,"Nanochanneled device and related methods",published 2013 
• USpatent 8563022,Decuzzi P, Ferrari M,"Particles for cell targeting",published 2013 
• USpatent 8568877,Ferrari M, Liu X, Chiappini C, Fakhoury JR,"Porous and non-porous nanostructures",published 2013 
• USpatent 8173115,Ferrari M, Decuzzi P,"Particle compositions with a pre-selected cell internalization mode",published 2012 
• USpatent 7993271,Liu J, Ferrari M, Rokhlin SI, Sedmark DD,"System and method for screening tissue",published 2011 
• USpatent 6355270,Ferrari M, Dehlinger PJ, Martin FJ, Grove CF, Friend DR,"Particles for oral delivery of peptides and proteins",published 2002 
• USpatent 6405066,Essenpreis M, Desai TA, Ferrari M, Hansford DJ,"Implantable analyte sensor",published 2002 
• USpatent 6015559,Keller CG, Ferrari M,"High vertical aspect ratio thin film structures",published 2000 
• USpatent 6044981,Chu WH, Ferrari M,"Microfabricated filter with specially constructed channel walls and containment well, and capsule constructed with such filters [II]",published 2000 
• USpatent 6107102,Ferrari M,"Therapeutic microdevices and methods of making and using same",published 2000 
• USpatent 5985164,Chu WH, Ferrari M,"Method for forming a filter",published 1999 
• USpatent 5893974,Keller CG, Ferrari M,"Microfabricated capsules for immunological isolation of cell transplants",published 1999 
• USpatent 5938923,Tu J, Ferrari M,"Microfabricated filter and capsule using a substrate sandwich",published 1999 
• USpatent 5948255,Keller CG, Ferrari M,"Microfabricated particle thin film filter and method of making it",published 1999 
• USpatent 5985328,Chu WH, Ferrari M,"Micromachined porous membranes with bulk support [II]",published 1999 
• USpatent 5770076,Chu WH, Ferrari M,"Micromachined capsules having porous membranes and bulk supports [I]",published 1998 
• USpatent 5798042,Chu WH, Ferrari M,"Microfabricated filter with specially constructed channel walls and containment well, and capsule constructed with such filters [I]",published 1998 

Honors, decorations, awards and distinctions

• 2008 Fellow, American Institute for Medical and Biological Engineering ^[35]
• 2009 Fellow, American Association for the Advancement of Science ^[36]
• 2011 Founders Award, Controlled Release Society ^[37]
• 2015 Aurel Stodola Medal, Mechanical Engineering, ETH Zurich, Switzerland ^[38]

Personal life

Ferrari met and married his first wife Marialuisa while they were both students at the University of Padova, and they moved to Berkeley, California. While he was faculty at the University of California Berkeley, Marialuisa died from cancer. ^{[39] [10] [11]} Ferrari married Paola Del Zotto from Udine, Italy in 1995. He has five children, including two sets of twins. ^{[39] [10]}

References

1. "Mauro Ferrari". Scholar.google.com. Retrieved 13 June 2017.
2. "Nano-balls filled with poison wipe out metastatic cancer in mice". Science . 14 March 2016. Retrieved 23 July 2017.
3. "National Cancer Institute Alliance for Nanotechnology". National Institutes of Health. Retrieved 2 March 2017.
4. Kulkarni, Rajan (2007). "Nano-Bio-Genesis: tracing the rise of nanotechnology and nanobiotechnology as 'big science'". Journal of Biomedical Discovery and Collaboration. 2 (3): 3. doi: 10.1186/1747-5333-2-3 . PMC   1976605 . PMID   17629932.
5. Burgess, Rob. 2012. "Understanding Nanomedicine: An Introductory Textbook". Singapore: Pan Stanford. ISBN   9789814316385
6. Jones, Dan (2007). "Cancer nanotechnology: small, but heading for the big time". Nature Reviews Drug Discovery. 6 (3): 174–175. doi:10.1038/nrd2285. PMID   17396287. S2CID   7836010.
7. "Nanotechnology". Nature Reviews Drug Discovery. 8 (11): 911. 2009. doi: 10.1038/nrd3029 .
8. "Leadership Team - Board of Directors: Mauro Ferrari, PhD". Arrowhead Pharmaceuticals. Retrieved 5 January 2025.
9. Ferrari, Mauro (23 March 2011). "Transcript: The Marvels of Nanotechnology" (PDF). Columbia University Crossroads Culture Center. Retrieved 28 February 2017.
10. Ferrari, Mauro (23 March 2011). "Event: The Marvels of Nanotechnology". Columbia University Crossroads Culture Center. Retrieved 28 February 2017.
11. Chien, Shanley (2017). "TMC Spotlight: Mauro Ferrari, Ph.D." TMC News. 4 (2): 7–8. Retrieved 2 March 2017.
12. "Mauro Ferrari, Ph.D Joins The Methodist Hospital Research Institute as President and CEO". Newswise. 12 August 2010. Retrieved 16 June 2017.
13. Ferrari M (2009). "Straight talk with Mauro Ferrari". Nature Medicine. 15 (7): 716–7. doi:10.1038/nm0709-716. PMID   19584847. S2CID   205380426.
14. Commission appoints Mauro Ferrari as next President of the European Research Council European Commission, press release of 14 May 2019.
15. "ERC member:Mauro Ferrari". European Research Council. Retrieved 5 January 2025.
16. "EU science chief resigns with blast at coronavirus response". Financial Times. 7 April 2020. Retrieved 7 April 2020.
17. "Frustrated president of EU's top science panel quits over COVID-19 response". The Globe and Mail Inc. 7 April 2020.
18. Ferrari, Mauro (7 April 2020). "Return to the Frontlines, to the Frontiers - Statement by Mauro Ferrari" . Retrieved 30 June 2020.
19. McGee, Luke (10 April 2020). "Analysis: The EU has bungled its response to coronavirus and it might never fully recover". CNN. Retrieved 30 June 2020.
20. Wallace, Nicholas (8 April 2020). "Top EU scientist pushed out over coronavirus spat". Science Magazine. Retrieved 30 June 2020.
21. European Research Council. "RESIGNATION OF MAURO FERRARI – STATEMENT BY THE SCIENTIFIC COUNCIL". ERC. Retrieved 8 April 2020.
22. Resignation of Mauro Ferrari – Statement by the Scientific Council European Commission, ERC press release of 8 April 2020.
23. Kelly, Éanna (16 April 2020). "Mauro Ferrari rejects criticism of his performance levelled by the European Research Council's scientific board: Ex-ERC chief defends his record and says he remains a supporter of the ERC's objectives". Science Business. Retrieved 10 May 2020.
24. Lantier, Alex (13 April 2020). "Fired researcher Mauro Ferrari denounces EU inaction on COVID-19". wsws.org. Retrieved 10 May 2020.
25. Wallace, Nicholas (14 April 2020). "EU science chief defends record after ouster over coronavirus plans". Science Magazine. Retrieved 30 June 2020.
26. Kelly, Éanna; Hudson, Richard L. (29 October 2020). "Exclusive: A look inside the last days of Mauro Ferrari at the European Research Council". ScienceBusiness. Retrieved 26 May 2023.
27. Mauro Ferrari AMBER.
28. About Us Arrowhead Pharmaceuticals.
29. Dead Sea Research Institute
30. Engineering Leadership Board Cullen College of Engineering, University of Houston.
31. "Mauro Ferrari". Houstonmethodist.org. Archived from the original on 14 November 2017. Retrieved 15 June 2017.
32. "Phase 1 - Physical Sciences-Oncology Centers: The Methodist Hospital Research Institute". National Cancer Institute: Physical Sciences in Oncology. Retrieved 15 June 2017.
33. Xu R, et al. (2016). "An injectable nanoparticle generator enhances delivery of cancer therapeutics". Nat Biotechnol. 34 (4): 414–8. doi:10.1038/nbt.3506. PMC   5070674 . PMID   26974511.
34. Nizzero, Sara; Goel, Shreya; Hinkle, Louis E.; Wu, Xiaoyan; Li, Chao; Ferrari, Mauro; Shen, Haifa (June 2020). "Retraction of the Research Article: "Molecular targeting of FATP4 transporter for oral delivery of therapeutic peptide" by Z. Hu, S. Nizzero, S. Goel, L. E. Hinkle, X. Wu, C. Li, M. Ferrari and H. Shen". Science Advances. 6 (26): eabc9572. Bibcode:2020SciA....6.9572N. doi:10.1126/sciadv.abc9752. ISSN   2375-2548. PMC   7319764 . PMID   32637628.
35. "Three BME Faculty Elected to American Institute for Medical and Biological Engineering (AIMBE) Fellows". The University of Texas. Retrieved 13 June 2017.
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37. "CRS Founders Award Recipients". Controlledreleasesociety.org. Archived from the original on 5 July 2016. Retrieved 16 June 2017.
38. "TNanomedicine pioneer Mauro Ferrari at ETH Zurich". ETH Zurich. 26 March 2015. Retrieved 16 June 2017.
39. Ferrari, Mauro (23 March 2011). "Transcript: The Marvels of Nanotechnology" (PDF). Columbia University Crossroads Culture Center. Retrieved 28 February 2017.