Medronic acid

Medronic acid
Names
	Preferred IUPAC name Methylenebis(phosphonic acid)
	Other names methanediphosphonic acid; methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP
Identifiers
CAS Number	1984-15-2 ;
3D model (JSmol)	Interactive image ;
ChEBI	CHEBI:43945 ;
ChEMBL	ChEMBL180570 ;
ChemSpider	15308 ;
ECHA InfoCard	100.016.229
KEGG	D04887 ;
PubChem CID	16124 ;
UNII	73OS0QIN3O ;
CompTox Dashboard (EPA)	DTXSID8045696 ;
	InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N ;
	SMILES O=P(O)(O)CP(=O)(O)O;
Properties
Chemical formula	CH6O6P2
Molar mass	176.001 g·mol−1
Melting point	199 to 200 °C (390 to 392 °F; 472 to 473 K)
Hazards
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	45-50 mg/kg (i.v., mice, rabbits)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated June 08, 2025

Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, ^99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

References

1 2 Budavari, Susan, ed. (1996). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.). Merck. ISBN 0911910123.

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[Merck-1] 1 2 Budavari, Susan, ed. (1996). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.). Merck. ISBN 0911910123.

[1]

Names

Preferred IUPAC name Methylenebis(phosphonic acid)
Other names methanediphosphonic acid; methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP
Identifiers
CAS Number	1984-15-2 ^N
3D model (JSmol)	Interactive image
ChEBI	CHEBI:43945 ^N
ChEMBL	ChEMBL180570 ^Y
ChemSpider	15308 ^Y
ECHA InfoCard	100.016.229
KEGG	D04887 ^Y
PubChem CID	16124
UNII	73OS0QIN3O ^N
CompTox Dashboard (EPA)	DTXSID8045696
InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)^Y Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N^Y
SMILES O=P(O)(O)CP(=O)(O)O
Properties
Chemical formula	CH₆O₆P₂
Molar mass	176.001 g·mol⁻¹
Melting point	199 to 200 °C (390 to 392 °F; 472 to 473 K)^[1]
Hazards
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	45-50 mg/kg (i.v., mice, rabbits)^[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references