Michael Lynch (geneticist)

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Michael Lynch
Born (1951-12-06) December 6, 1951 (age 73)
Alma mater University of Minnesota
Known forcontributions to Population Genetics, Quantitative Genetics,
Awards
Sciences
Scientific career
Fields Genetics, Population genetics, Evolution
Institutions Indiana University, Arizona State University

Michael Lynch (born December 6, 1951) is an American geneticist who is the Director of the Biodesign Institute for Mechanisms of Evolution at Arizona State University, Tempe, Arizona.

Contents

Biography

Lynch held a Distinguished Professorship of Evolution, Population Genetics and Genomics at Indiana University, Bloomington, Indiana. Besides over 250 [1] [2] papers, especially in population genetics, he has written a two volume textbook with Bruce Walsh. Alongside this textbook he has also published two other books. He promotes neutral theories to explain genomic architecture based on the effects of population sizes in different lineages; [3] he presented this point of view in his 2007 book "The Origins of Genome Architecture". [4] In 2009, he was elected to the National Academy of Sciences (Evolutionary Biology). Lynch was a Biology undergraduate at St. Bonaventure University and received a B.S. in Biology in 1973. He obtained his PhD from the University of Minnesota (Ecology and Behavioral Biology) in 1977.

Research

Evolution of genome architecture

Population genetics principles, phylogenetic analyses, rate calculations, and allele frequency spectra of derived SNPs are employed to understand evolutionary mechanisms behind eukaryotic genome complexity. [5] Hypotheses around the ideas that eukaryotic genome complexity evolved as a result of a passive response to reduced population size, deleterious newly arisen introns in species of Daphnia, [6] genomic response to alterations in population size and mutation rates in E. coli [7] and the evolutionary fates of duplicate genes in of species of Paramecium using complete genomic sequencing are investigated. [8]

Role of mutation in evolution

Most mutations are mildly deleterious [9] and can eventually lead to decreased evolutionary fitness in a species. Using the Tree of Life, Lynch investigates the significant variation across diverse invertebrates and simple eukaryotic and prokaryotic organisms using a mutation-accumulation strategy. [10] To address this mutation diversity and the load of mutation on survival in some species, a novel method involving a mutation accumulation strategy that is followed by whole genome sequencing allows for estimation of error rates in transcription and variation among eukaryotic lineages. [11] The work done to estimate this variation translates to population genetic theories for mutation rates and how somatic mutations can eventually evolve to multicellularity. These approaches promote the evolutionary ideas of the drift-barrier hypothesis. [12]

Role of recombination in evolution

A major drawback of sexual recombination is the separation of complexes of alleles that have adapted together. Study of Daphnia pulex , a microcrustacean that has the ability to reproduce sexually and asexually based upon which is advantageous at particular evolutionary time points, allows for direct quantification and comparison of recombination rates in mobile genetic elements in sexual and asexual lineages. [13] This species of Daphnia's asexual lineage is rather young in an evolutionary time perspective and rapidly go extinct. [14] It is hypothesized that this rapid extinction is caused by a loss of heterozygosity caused by asexual reproduction as well as gene conversion exposing them to pre-existing deleterious mutations. [9] A new reference genome assembly of this species has recently been generated [15] and attention to the role of recombination in Daphnia has been of hallmark importance to Lynch's research in recent years.

Evolutionary cell biology

Currently, no formal field of evolutionary cell biology exists. The link between the evolution of phenotypes and molecular evolution is found at the level of cellular architecture. Recent work spearheaded by Michael Lynch and his lab seeks to link traditional evolutionary theory with molecular and cellular biology alongside comparative cellular biology observations. Using Paramecium as a model species, studies of the evolutionary basis of: evolution of cellular surveillance mechanisms, barriers as a result of random genetic drift on molecular perfection, multimeric proteins, vesicle transport and gene expression. [16] [17]

Honors and awards

See also

References

  1. "Publications | The Biodesign Institute | ASU". biodesign.asu.edu. Retrieved 2017-11-08.
  2. "Michael Lynch". scholar.google.com. Retrieved 2023-09-28.
  3. Lynch, Michael (2007-05-15). "The frailty of adaptive hypotheses for the origins of organismal complexity". Proceedings of the National Academy of Sciences. 104 (suppl_1): 8597–8604. doi: 10.1073/pnas.0702207104 . ISSN   0027-8424. PMC   1876435 . PMID   17494740.
  4. "The origins of genome architecture". Choice Reviews Online. 45 (2): 45–0862-45-0862. 2007-10-01. doi:10.5860/choice.45-0862 (inactive 1 February 2025). ISSN   0009-4978.{{cite journal}}: CS1 maint: DOI inactive as of February 2025 (link)
  5. Li, Wenli; Tucker, Abraham E.; Sung, Way; Thomas, W. Kelley; Lynch, Michael (2009-11-27). "Extensive, Recent Intron Gains in Daphnia Populations". Science. 326 (5957): 1260–1262. Bibcode:2009Sci...326.1260L. doi:10.1126/science.1179302. ISSN   0036-8075. PMC   3878872 . PMID   19965475.
  6. Li, Wenli; Kuzoff, Robert; Wong, Chen Khuan; Tucker, Abraham; Lynch, Michael (2014-09-01). "Characterization of Newly Gained Introns in Daphnia Populations". Genome Biology and Evolution. 6 (9): 2218–2234. doi:10.1093/gbe/evu174. PMC   4202315 . PMID   25123113.
  7. Lynch, Michael (2010). "Evolution of the mutation rate". Trends in Genetics. 26 (8): 345–352. doi:10.1016/j.tig.2010.05.003. PMC   2910838 . PMID   20594608.
  8. Lynch, Michael (2006-09-11). "Streamlining and Simplification of Microbial Genome Architecture". Annual Review of Microbiology. 60 (1): 327–349. doi:10.1146/annurev.micro.60.080805.142300. ISSN   0066-4227. PMID   16824010.
  9. 1 2 Loewe, Laurence; Hill, William G. (2010-04-27). "The population genetics of mutations: good, bad and indifferent". Philosophical Transactions of the Royal Society of London B: Biological Sciences. 365 (1544): 1153–1167. doi:10.1098/rstb.2009.0317. ISSN   0962-8436. PMC   2871823 . PMID   20308090.
  10. Lynch, Michael; Conery, John; Burger, Reinhard (1995-10-01). "Mutation Accumulation and the Extinction of Small Populations". The American Naturalist. 146 (4): 489–518. Bibcode:1995ANat..146..489L. doi:10.1086/285812. ISSN   0003-0147.
  11. Lynch, Michael; Gabriel, Wilfried (1990-11-01). "Mutation Load and the Survival of Small Populations". Evolution. 44 (7): 1725–1737. doi: 10.1111/j.1558-5646.1990.tb05244.x . ISSN   1558-5646. PMID   28567811.
  12. Lynch, Michael; Ackerman, Matthew S.; Gout, Jean-Francois; Long, Hongan; Sung, Way; Thomas, W. Kelley; Foster, Patricia L. (2016-10-14). "Genetic drift, selection and the evolution of the mutation rate". Nature Reviews Genetics. 17 (11): 704–714. doi:10.1038/nrg.2016.104. ISSN   1471-0064. PMID   27739533.
  13. Jiang, Xiaoqian; Tang, Haixu; Ye, Zhiqiang; Lynch, Michael (2017-02-01). "Insertion Polymorphisms of Mobile Genetic Elements in Sexual and Asexual Populations of Daphnia pulex". Genome Biology and Evolution. 9 (2): 362–374. doi:10.1093/gbe/evw302. PMC   5381639 . PMID   28057730.
  14. Omilian, Angela R.; Cristescu, Melania E. A.; Dudycha, Jeffry L.; Lynch, Michael (2006-12-05). "Ameiotic recombination in asexual lineages of Daphnia". Proceedings of the National Academy of Sciences. 103 (49): 18638–18643. Bibcode:2006PNAS..10318638O. doi: 10.1073/pnas.0606435103 . ISSN   0027-8424. PMC   1693715 . PMID   17121990.
  15. Ye, Zhiqiang; Xu, Sen; Spitze, Ken; Asselman, Jana; Jiang, Xiaoqian; Ackerman, Matthew S.; Lopez, Jacqueline; Harker, Brent; Raborn, R. Taylor (2017-05-01). "A New Reference Genome Assembly for the Microcrustacean Daphnia pulex". G3: Genes, Genomes, Genetics. 7 (5): 1405–1416. doi:10.1534/g3.116.038638. ISSN   2160-1836. PMC   5427498 . PMID   28235826.
  16. McGrath, Casey L.; Gout, Jean-Francois; Doak, Thomas G.; Yanagi, Akira; Lynch, Michael (2014-08-01). "Insights into Three Whole-Genome Duplications Gleaned from the Paramecium caudatum Genome Sequence". Genetics. 197 (4): 1417–1428. doi:10.1534/genetics.114.163287. ISSN   0016-6731. PMC   4125410 . PMID   24840360.
  17. Catania, Francesco; Wurmser, François; Potekhin, Alexey A.; Przyboś, Ewa; Lynch, Michael (2009-02-01). "Genetic Diversity in the Paramecium aurelia Species Complex". Molecular Biology and Evolution. 26 (2): 421–431. doi:10.1093/molbev/msn266. ISSN   0737-4038. PMC   3888249 . PMID   19023087.
  18. "Past and Present GSA Officers". GSA. Archived from the original on 4 December 2018. Retrieved 27 November 2018.