Michael McClelland (academic)

Last updated

Michael McClelland
Education
Alma mater
Scientific career
Fields
Institutions
Doctoral advisor Daniel Vapnek
Other academic advisors Charles Cantor
Allan Wilson

Michael McClelland is an academic. He is a professor of microbiology and genetics at the University of California, Irvine. [1]

Contents

Early life and education

Mcclelland had his early education at the University of Ghana Primary School, Methodist College, Belfast, and Boynton Junior High School in Ithaca, New York.

He had his secondary education at the Accra Academy from 1970 to 1972, and King Edward VII School, Sheffield from 1973 to 1975. He then proceeded to the University of Bristol, England, where he obtained his bachelor's degree in biochemistry in 1978.

In 1980, McClelland moved to the United States for his postgraduate studies at the University of Georgia, and graduated with a doctorate degree in 1983 with his research studies in Molecular and Population Genetics. He then continued at the University of California, Berkeley for a post doctoral research in Molecular Evolution under the supervision of Evolutionary Biologist, Allan Wilson from 1983 to 1984. After his post doctoral research at the University of California, Berkeley, McClelland entered the Columbia University Vagelos College of Physicians and Surgeons as a Lucille. P. Markey Scholar for a post doctoral research in Molecular Genetics under the direction of molecular geneticist Charles Cantor. [2] His research lasted from 1984 to 1986. [1] [3]

Career

McClelland taught Chemistry and Biology at Beveweerd School prior to entering the University of Georgia for his postgraduate studies. Following his second post doctoral research at the Columbia University Vagelos College of Physicians and Surgeons, he joined the University of Chicago's Biochemistry Molecular Biology Department in 1986 as an L. P. Markey Assistant Professor. [4] [5] [6] [7] In 1989, he became the Research Program Director of the California Institute Biological Research, San Diego, California. [3] [8] [9] [10] [11] [12]

He worked in this capacity until 1995 when he was appointed Professor and Director of Genomics and Bioinformatics at the Sidney Kimmel Cancer Center, San Diego, California. [13] [14] [15] [16] [17]

In 2009, he was appointed Scientific Director of the Vaccine Research Institute. [18] At the said period, McClelland doubled as a visiting researcher at the University of California, Irvine. In April 2011 he was made Adjunct Professor of the university's department of Pathology and Laboratory Medicine. He remained Director of Genomics and Bioinformatics at the Sidney Kimmel Cancer Center, San Diego, California until 2013 when he became a Professor at the Department of Microbiology and Molecular Genetics at the University of California, Irvine. [1]

McClelland is a member of the UCI Cancer Centre. He served on the NCI (National Cancer Institute) Directors Challenge panel; twelve NCI RFA and ad hoc panels, and three USDA and NSF panels. He was the Chairman of Novel Technologies RFA Study Section, and an external reviewer for the Department of Education (UK). [1]

Research work

McClelland's works are in the areas of salmonella, cancer, prostate, breast and DNA Methylation. He serves on the Editorial board of the International Journal of Microbiology. He also works with companies to develop cancer prognosticators and cancer therapies. He served on the Editorial board of Nucleic Acids Research from 1992 to 2007. He has authored over 350 peer reviewed papers and his works have been cited over 40,000 times. [1] [3] [19] He has 13 patents and his works are often featured in journals such as; Nature , Science , Nucleic Acids Research, Nature Genetics , Proceedings of the National Academy of Sciences, International Journal of Systematic and Evolutionary Microbiology , Trends in Genetics , Journal of Bacteriology , Theoretical and Applied Genetics , Molecular Microbiology , Genes & Development , and Genetics . [19]

Related Research Articles

<span class="mw-page-title-main">Genomics</span> Discipline in genetics

Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain.

<span class="mw-page-title-main">Michael Smith (chemist)</span> British-born Canadian biochemist, businessman and Nobel Prize laureate (1932–2000)

Michael Smith was a British-born Canadian biochemist and businessman. He shared the 1993 Nobel Prize in Chemistry with Kary Mullis for his work in developing site-directed mutagenesis. Following a PhD in 1956 from the University of Manchester, he undertook postdoctoral research with Har Gobind Khorana at the British Columbia Research Council in Vancouver, British Columbia, Canada. Subsequently, Smith worked at the Fisheries Research Board of Canada Laboratory in Vancouver before being appointed a professor of biochemistry in the UBC Faculty of Medicine in 1966. Smith's career included roles as the founding director of the UBC Biotechnology Laboratory and the founding scientific leader of the Protein Engineering Network of Centres of Excellence (PENCE). In 1996 he was named Peter Wall Distinguished Professor of Biotechnology. Subsequently, he became the founding director of the Genome Sequencing Centre at the BC Cancer Research Centre.

<span class="mw-page-title-main">Leroy Hood</span> American biologist (born 1938)

Leroy "Lee" Edward Hood is an American biologist who has served on the faculties at the California Institute of Technology (Caltech) and the University of Washington. Hood has developed ground-breaking scientific instruments which made possible major advances in the biological sciences and the medical sciences. These include the first gas phase protein sequencer (1982), for determining the sequence of amino acids in a given protein; a DNA synthesizer (1983), to synthesize short sections of DNA; a peptide synthesizer (1984), to combine amino acids into longer peptides and short proteins; the first automated DNA sequencer (1986), to identify the order of nucleotides in DNA; ink-jet oligonucleotide technology for synthesizing DNA and nanostring technology for analyzing single molecules of DNA and RNA.

<span class="mw-page-title-main">Marco Marra</span> Canadian geneticist

Marco A. Marra is a Distinguished Scientist and Director of Canada's Michael Smith Genome Sciences Centre at the BC Cancer Research Centre and Professor of Medical Genetics at the University of British Columbia (UBC). He also serves as UBC Canada Research Chair in Genome Science for the Canadian Institutes of Health Research and is an inductee in the Canadian Medical Hall of Fame. Marra has been instrumental in bringing genome science to Canada by demonstrating the pivotal role that genomics can play in human health and disease research.

William McGinnis, Ph.D. is a molecular biologist and professor of biology at the University of California San Diego. At UC San Diego he has also served as the Chairman of the Department of Biology from July 1998 to June 1999, as Associate Dean of the Division of Natural Sciences from July 1, 1999 to June 2000, and as Interim Dean of the newly established Division of Biological Sciences from July 1, 2000 to February 1, 2001. Dr. McGinnis was appointed Dean of the Divisional Biological Sciences on July 1, 2013.

<span class="mw-page-title-main">David Botstein</span> American biologist

David Botstein is an American biologist who is the chief scientific officer of Calico. He was the director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University from 2003 to 2013, where he remains an Anthony B. Evnin Professor of Genomics.

Gerald Francis "Jerry" Joyce is president and professor at the Salk Institute for Biological Studies and was previously the director of the Genomics Institute of the Novartis Research Foundation. He is best known for his work on in vitro evolution, for the discovery of the first DNA enzyme (deoxyribozyme), for his work in discovering potential RNA world ribozymes, and more in general for his work on the origin of life.

Wen-Hsiung Li is a Taiwanese-American scientist working in the fields of molecular evolution, population genetics, and genomics. He is currently the James Watson Professor of Ecology and Evolution at the University of Chicago and a Principal Investigator at the Institute of Information Science and Genomics Research Center, Academia Sinica, Taiwan.

Jeffrey Lynn Bennetzen is an American geneticist on the faculty of the University of Georgia (UGA). Bennetzen is known for his work describing codon usage bias in yeast, and E. coli; being the first to clone and sequence an active transposon in plants, discovering that most of the DNA in plant genomes was a particular class of mobile DNA (LTR-retrotransposons); solving the C-value paradox; proposing sorghum and Setaria as model grasses; showing that rice centromeres were hotspots for recombination, but not crossovers; and developing a technique to date polyploidization events. He is an author, with Sarah Hake of the book "Handbook of Maize." Bennetzen was elected to the US National Academy of Sciences in 2004.

<span class="mw-page-title-main">David Haussler</span> American bioinformatician

David Haussler is an American bioinformatician known for his work leading the team that assembled the first human genome sequence in the race to complete the Human Genome Project and subsequently for comparative genome analysis that deepens understanding the molecular function and evolution of the genome.

<span class="mw-page-title-main">Joachim Messing</span> German-American biologist (1946–2019)

Joachim Wilhelm "Jo" Messing was a German-American biologist who was a professor of molecular biology and the fourth director of the Waksman Institute of Microbiology at Rutgers University.

Dr. Paul R. Billings is a distinguished American doctor, lecturer, researcher, professor, and consultant on genetic information. His research interests include the impact of genomic data on society, the integration of genomics with diagnostics in health and medical care, and individualized genomic medicine. He is the author of over 250 publications and has appeared on talk shows such as The Oprah Winfrey Show and 60 Minutes. He is currently the CEO and Director of Biological Dynamics.

<span class="mw-page-title-main">Nagendra Kumar Singh</span> Indian agricultural scientist (born 1958)

Nagendra Kumar Singh is an Indian agricultural scientist. He is presently a National Professor Dr. B.P. Pal Chair and JC Bose National Fellow at ICAR-National Institute for Plant Biotechnology, Indian Agricultural Research Institute, New Delhi. He was born in a small village Rajapur in the Mau District of Uttar Pradesh, India. He is known for his research in the area of plant genomics, genetics, molecular breeding and biotechnology, particularly for his contribution in the decoding of rice, tomato, wheat, pigeon pea, jute and mango genomes and understanding of wheat seed storage proteins and their effect on wheat quality. He has made significant advances in comparative analysis of rice and wheat genomes and mapping of genes for yield, salt tolerance and basmati quality traits in rice. He is one of the highest cited agricultural scientists from India for the last five years.

Richard K. Wilson is a leading American molecular geneticist. He is the founding Executive Director of the Institute for Genomic Medicine at Nationwide Children’s Hospital and Professor of Pediatrics at the Ohio State University College of Medicine. He received his A.B. degree (Microbiology) from Miami University in Ohio in 1981, his Ph.D. (Chemistry) from the University of Oklahoma in 1986, and was a Research Fellow in the Division of Biology at the California Institute of Technology (1986-1990). In 1990, Dr. Wilson joined the faculty of Washington University School of Medicine where he co-founded the Genome Sequencing Center/McDonnell Genome Institute. At Washington University, Dr. Wilson was the Alan A. and Edith L. Wolff Distinguished Professor of Medicine, Professor of Genetics, Professor of Molecular Microbiology, and a member of the Senior Leadership Committee of the Siteman Cancer Center.

David Mahan Knipe is the Higgins Professor of Microbiology and Molecular Genetics in the Department of Microbiology at the Harvard Medical School in Boston, Massachusetts and co-chief editor of the reference book Fields Virology. He returned to the Chair of the Program in Virology at Harvard Medical School in 2019, having previously held the position from 2004 through 2016 and served as interim Co-Chair of the Microbiology and Immunobiology Department from 2016 through 2018.

<span class="mw-page-title-main">Don W. Cleveland</span> American cancer biologist and neurobiologist

Don W. Cleveland is an American cancer biologist and neurobiologist.

Richard David Kolodner is an American scientist with Ludwig Cancer Research who has made research contributions to the genetic basis for inherited susceptibility to common cancers. He is a Distinguished Professor of Cellular and Molecular Medicine at the UC San Diego School of Medicine. Kolodner is a member of the National Academy of Sciences and National Academy of Medicine, and he is a fellow of the American Academy of Arts and Sciences.

<span class="mw-page-title-main">Laurence H. Kedes</span> American academic (1937–2021)

Laurence H. Kedes was an American scientist in the fields of gene expression, genomics, and cellular differentiation. His first faculty position was at Stanford University (1970-1989), where he was promoted to full professor in the Department of Medicine and focused on basic molecular biology and gene expression. In 1988, the University of Southern California (USC) recruited Kedes to spearhead a campus-wide initiative to strengthen their molecular biology and genetics research programs. At USC, Kedes conceived and developed the Institute of Genetic Medicine, becoming its founding director (1989-2008) as well as the William Keck Professor (1988-2009) and Chair (1988-2002) of the Department of Biochemistry and Molecular Biology.

Jeffrey Donald Palmer is a Distinguished Professor of Biology at Indiana University Bloomington.

<span class="mw-page-title-main">Anton Gartner</span>

Anton Gartner is a geneticist and biologist utilizing the nematode worm Caenorhabditis elegans as a model system He is a distinguished professor at the Ulsan National Institute of Science and Technology (UNIST) in Korea and is one of the two associate directors of the IBS Center for Genomic Integrity located on the UNIST campus.

References

  1. 1 2 3 4 5 "Michael McClelland" . Retrieved 8 April 2021.
  2. Chirikjian, Jack G. (1987). Restriction Endonucleases and Methylases. Elsevier. ISBN   978-0-444-01285-2.
  3. 1 2 3 "Michael McClelland - San Diego Institute for Biological Research". sdibr.org. Retrieved 8 April 2021.
  4. Annual Report of Cancer Research at the University of Chicago. The University. 1987.
  5. TRNA, Cloned Human DNA and E. Coli Sequences, Histone Genes and Restriction Enzyme Recognition Sequences. IRL Press. 1989.
  6. TRNA, Cloned Human DNA and E. Coli Sequences, Histone Genes and Restriction Enzyme Recognition Sequences. IRL Press. 1989.
  7. Abstracts of Papers Presented at the 1989 Meeting on Genome Mapping and Sequencing: April 26-April 30, 1989. Cold Spring Harbor Laboratory. 1989.
  8. New Horizons in Gene Amplification Technologies: New Techniques and Applications, June 8-10, 1994, Hyatt Regency, San Francisco, California. Cambridge Healthtech Institute. 1994.
  9. Human Genome News. Biomedical and Environmental Information Analysis Section of the Health and Safety Research Division at Oak Ridge National Laboratory. 1989.
  10. Innis, Michael A.; Gelfand, David H.; Sninsky, John J. (6 July 1995). PCR Strategies. Elsevier. ISBN   978-0-08-053854-9.
  11. Lockyer, Sir Norman (1869). Nature. Macmillan Journals Limited.
  12. Sobral, Bruno W. S. (6 December 2012). The Impact of Plant Molecular Genetics. Springer Science & Business Media. ISBN   978-1-4615-9855-8.
  13. Project, Yellowstone Wolf (2000). Annual Report. National Park Service, Yellowstone Center for Resources.
  14. McClelland, Michael; Pardee, Arthur Beck (1999). Expression Genetics: Accelerated and High-throughput Methods. BioTechniques Books. ISBN   978-1-881299-24-0.
  15. Hather, Gregory James (2008). Statistical Analysis of DNA Sequence Motifs and Microarray Data. University of California, Berkeley.
  16. Cancer Research. University of Chicago Press. 2008.
  17. Caetano-Anollés, Gustavo; Gresshoff, Peter M. (16 September 1997). DNA Markers: Protocols, Applications, and Overviews. Wiley. ISBN   978-0-471-16067-0.
  18. Wiedmann, Martin; Zhang, Wei (4 February 2011). Genomics of Foodborne Bacterial Pathogens. Springer Science & Business Media. ISBN   978-1-4419-7686-4.
  19. 1 2 "Michael McClelland". scholar.google.com. Retrieved 8 April 2021.