U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International Falls, Minnesota. It is the primary north–south route in northwestern Wisconsin, serving as a vital link between I-94 at Eau Claire, Wisconsin and the Twin Ports of Superior, Wisconsin, and Duluth, Minnesota. The entire route from Eau Claire to the city limits of Superior is a four lane divided highway. The highway's northern terminus is at the Fort Frances–International Falls International Bridge in International Falls, Minnesota, at the Canada–US border. Its southern terminus is in La Crosse, Wisconsin, at U.S. Highway 14.
U.S. Highway 218 (US 218) is an original United States Highway that was created in 1926. Although technically a spur of US 18, US 218 neither begins nor ends at US 18, but overlaps US 18 for eight miles (13 km) near Charles City, Iowa. US 218 begins at U.S. 136 in downtown Keokuk and ends 319 miles (513 km) away at Interstate 35 (I-35) and US 14 at Owatonna, Minnesota. A large portion of US 218 in Iowa is part of the Avenue of the Saints, which connects St. Louis, Missouri, and Saint Paul, Minnesota.
Minnesota State Highway 65 is a highway in the east–central and northeast parts of the U.S. state of Minnesota, which starts at its split from I-35W, skipping past the downtown Minneapolis core, only to resume at the intersection with Washington Avenue at the north end of downtown Minneapolis to continue north to its northern terminus at its intersection with U.S. Highway 71 (US 71) in Littlefork near International Falls.
Minnesota State Highway 7, or Trunk Highway 7, is a state highway in Minnesota, which runs from its intersection with MN 28 near Beardsley and continues east to its terminus with MN 100 and County Road 25 (CR 25) in St. Louis Park. The highway runs east–west for approximately 194.2 miles (312.5 km) through mostly rural farmland in the central part of the state. On its western end, it is part of the Minnesota River Valley Scenic Byway where it runs northwest–southeast along the Minnesota River and associated lakes near the border with the adjoining state of South Dakota. For roughly 24 miles (39 km) of its route, it runs concurrently with U.S. Highway 59 (US 59) between Appleton and Montevideo. In Montevideo, the highway turns to the east cutting across the state. It passes through several small towns before entering the Twin Cities metropolitan area. In the metro area, MN 7 follows an expressway through several suburbs before terminating in St. Louis Park. Two different segments have been listed on the National Highway System, system of roads considered important to the country.
Minnesota State Highway 5 is a 76.347-mile-long (122.869 km) highway in Minnesota, which runs from its intersection with MN 19 and MN 22 in Gaylord and continues east and northeast to its eastern terminus at its intersection with MN 120 in Maplewood. The route passes through downtown Saint Paul.
Minnesota State Highway 23 (MN 23) is a state highway that stretches from southwestern to northeastern Minnesota. At 343.723 miles (553.169 km) in length, it is the second longest state route in Minnesota, after MN 1.
Minnesota State Highway 610 (MN 610) is an east–west freeway in the Twin Cities region of Minnesota. The freeway connects Interstate 94 (I-94), County Road 81, and CR 130 in northern Hennepin County to U.S. Highway 10 (US 10) in southern Anoka County. MN 610 crosses the Mississippi River on the Richard P. Braun Bridge between suburban Brooklyn Park and Coon Rapids. The highway is 12.3 miles (19.8 km) long.
Minnesota State Highway 371 (MN 371) is a 107.411-mile-long (172.861 km) highway in central and north-central Minnesota. The route connects Minnesota's northern lakes region with the central part of the state. It runs south–north from U.S. Highway 10 (US 10) in Little Falls to US 2 in Cass Lake. MN 371 has become a heavily traveled arterial route that was once a two-lane roadway over almost all of its length, but has been widened to four lanes across most of its southern half. Much of the traffic utilizing the route is Twin Cities-based traffic heading to their cabins on one of the many northern lakes.
Minnesota State Highway 252 (MN 252) is a 4.4-mile-long (7.1 km) state highway in Minnesota, which runs from its interchange with Interstate 94 (I-94), I-694 and US Highway 52 (US 52) in Brooklyn Center and continues north to its northern terminus at its interchange with MN 610 in Brooklyn Park. MN 252 generally follows not far from the west bank of the Mississippi River throughout its route.
Minnesota State Highway 15 is a 154.322-mile-long (248.357 km) highway in south-central and central Minnesota, which runs from Iowa Highway 15 at the Iowa state line and continues north to its northern terminus at its interchange with U.S. Highway 10 outside of Sartell and Sauk Rapids, north of St. Cloud.
Minnesota State Highway 33 (MN 33) is a 19.748-mile (31.781 km) state highway in northeast Minnesota, which runs from its interchange with Interstate 35 (I-35) at Cloquet and continues to its northern terminus at its interchange with U.S. Highway 53 (US 53) at Independence. The highway is constructed as a four-lane expressway with a 65 mph (105 km/h) speed limit, except for a short distance through the city of Cloquet, where the route is located on a four-lane city surface street. MN 33 is a bypass of Duluth for travelers headed to the Iron Range of northern Minnesota and International Falls.
Minnesota State Highway 27 (MN 27) is a 247.623-mile-long (398.511 km) state highway in west-central and east-central Minnesota, which runs from its intersection with MN 28 in Browns Valley and continues east to its interchange with Interstate 35 (I-35) in Moose Lake. For part of its route, it runs concurrently with MN 65 in Kanabec and Aitkin counties between Woodland and Rice River Township.
Minnesota State Highway 41 (MN 41) is a 9.382-mile-long (15.099 km) highway in Minnesota, which runs from its intersection with U.S. Highway 169 in Jackson Township near Shakopee and continues north to its northern terminus at its intersection with State Highway 7 in Shorewood.
U.S. Highway 52 (US 52) enters the state of Minnesota at the unincorporated community of Prosper, north of the town of Burr Oak, Iowa. The route is marked north–south in Minnesota along its independent segment from the Iowa state line to downtown St. Paul. US 52 is not signed along the length of its concurrency with Interstate 94 (I-94) from downtown St. Paul to the North Dakota state line at Moorhead and Fargo.
County State-Aid Highway 81, also known as County Road 81, (County 81) is a county highway in Hennepin County, Minnesota, which runs from its interchange with Interstate 94 (I-94), CR 66, and CR 152 in the city of Minneapolis, and continues northwest to its terminus at Main Street in suburban Rogers. CR 81 is approximately 20 miles (32 km) long.
Hennepin County Road 122 (CR 122) or County State-Aid Highway 122 (CSAH 122) is an unsigned county state-aid highway within the city of Minneapolis, Hennepin County, Minnesota, United States, crossing the Mississippi River on the Washington Avenue Bridge.
U.S. Highway 169 (U.S. 169) is a major north–south highway in the U.S. state of Minnesota, connecting the Minnesota River valley with the Twin Cities and the Iron Range. Much of the route is built to expressway or freeway standards.
Six special routes of U.S. Route 169 exist, one each in Oklahoma, Kansas, Missouri, and Iowa, and two in Minnesota.
U.S. Highway 212 (US 212) within the state of Minnesota travels from the South Dakota state line in the west, crosses the southwestern part of the state, to the Minneapolis–Saint Paul metropolitan area in the east and end at its interchange with US 169 and State Highway 62 (MN 62) in the Minneapolis suburb of Edina. US 212 in Minnesota has an official length of 161.8 miles (260.4 km). It is an urban freeway within the Minneapolis–Saint Paul area and is mostly a two-lane rural road elsewhere in the state.
MN 5 at Chanhassen
CSAH 62
I-94 at Rogers 
US 10 / US 169 at Elk River 
