U.S. Route 400 is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada, Colorado, at an intersection with US 385. The highway's eastern terminus is southwest of Joplin, Missouri, near Loma Linda, at an interchange with Interstate 44, with which it shares with US 166. It originally ended in Garden City, Kansas; in 1996 it was extended to its current western terminus.
U.S. Route 24 or U.S. Highway 24 (US 24) is one of the original United States Numbered Highways of 1926 which runs east and west for most of its routing. It originally ran from Pontiac, Michigan, in the east to Kansas City, Missouri, in the west. Today, the highway's eastern terminus is in Independence Township, Michigan, at an intersection with Interstate 75 (I-75), and its western terminus is near Minturn, Colorado, at an intersection with I-70. The highway transitions from north–south to east–west signage at the Ohio–Michigan state line.
Interstate 435 (I-435) is an Interstate Highway beltway that encircles much of the Kansas City metropolitan area within the states of Kansas and Missouri in the United States.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S. Route 66, since US 666 was renumbered to US 491 in 2003.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route. Truckers refer to this road as "The Bee Line."
Interstate 255 (I-255) is a bypass route of I-55 in Greater St. Louis. Along with I-270, it forms a loop around the central portion of the bi-state metro area; a majority of I-255 is located on the Illinois half. It shares its southern terminus with I-270 at the junction with I-55; I-270 and I-255 go to the west and east, respectively. U.S. Route 50 (US 50) joins I-255 at Lemay Ferry Road. It crosses the Mississippi River on the Jefferson Barracks Bridge, enters Illinois, and then turns northeast. There is a junction with I-64, where US 50 breaks off and goes east, and then further north there is a junction with I-55 again, I-70, and US 40, all of which are all cosigned together. The next junction is another one with I-270, which is the northern terminus of I-255. After that, the limited-access freeway continues on as Illinois Route 255 (IL 255). I-255 is 30.82 miles (49.60 km) in length.
Route 66 is a fourteen-mile (21 km) long road in southwest Missouri, USA, which had previously been U.S. Route 66 for its final six years. The highway begins at Interstate 44, passes through Duenweg, Duquesne, and Joplin, then crosses into Kansas becoming K-66.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Missouri Route 740, better known as Stadium Boulevard, is a short highway located completely within the city of Columbia, Missouri, United States. Its western terminus is at Interstate 70/U.S. Route 40 (I-70/US 40), and its eastern terminus is at Maguire Boulevard in southeast Columbia, just east of U.S. Route 63 (US 63).
Route 291 is a state highway in the western part of the U.S. state of Missouri. Its southern terminus is at I-49/US 71 in Harrisonville; its northern terminus is at I-435 in Kansas City. The route was once designated as US 71 Bypass. Route 291 serves as a main arterial road and commercial strip in Liberty and Independence.
Missouri Route 269 is a highway in the Kansas City metropolitan area. Its total length is a short three miles (4.8 km), which is also entirely named Chouteau Trafficway as a segment of that much longer trafficway. The highway's northern terminus is at Interstate 35 (I-35) and its southern terminus is at Front Street—both in Kansas City, Missouri. The middle of the route includes an interchange with Route 210 in the small city of North Kansas City, Missouri.
Route 283 was a short highway in the Kansas City, Missouri regional area. Its northern terminus was at Interstate 29 (I-29) and U.S. Route 71 (US 71) in Kansas City; its southern terminus was at Route 9 at the northern city limit of North Kansas City. It was known locally as North Oak Trafficway.
Route 10 is a highway in Clay, Ray, and Carroll counties in western Missouri, United States. Its eastern terminus is at the concurrency of US 24/US 65 in Carrollton. Its western terminus is at US 69 in Excelsior Springs. A business loop of Route 10 travels through Richmond.
Interstate 55 (I-55) is a major north–south Interstate Highway in the US state of Illinois that connects St. Louis, Missouri, to the Chicago metropolitan area. It enters the state from Missouri near East St. Louis, Illinois, and runs to U.S. Route 41 near Downtown Chicago, where the highway ends, a distance of 294.38 miles (473.76 km). The road also runs through the Illinois cities of Springfield, Bloomington, and Joliet. The section in Cook County is officially named the Stevenson Expressway for the governor, and in DuPage County it's officially named the Joliet Freeway or the Will Rogers Freeway for the humorist. The section from the south suburbs to the area near Pontiac is officially named the Barack Obama Presidential Expressway after the president, who launched his political career from Illinois.
Interstate 35 (I-35) is an Interstate Highway that stretches from Laredo, Texas, in the south to Duluth in the north. The portion of it through Missouri travels nearly 115 miles (185 km) from just south of Kansas City, through the Downtown Loop, and across the Missouri River before leaving the downtown area. North of Kansas City, the highway travels north-northeast toward the Iowa state line near Eagleville, paralleling U.S. Route 69 (US 69).
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
K-254 is a 27.369-mile-long (44.046 km) state highway in the U.S. state of Kansas and links Wichita to El Dorado. K-254 begins at the intersection of Interstate 135 (I-135), I-235, U.S. Route 81 (US-81), K-15 and K-96 north of Wichita. It bypasses Kechi, Benton and Towanda, ending in downtown El Dorado at an intersection with US-54 and US-77. It is limited access from I-135 to just east of Kechi. It is then four-lane divided with at grade intersections to El Dorado with the exception of a diamond interchange at K-196. There is a stoplight interchange with I-35/Kansas Turnpike on the west side of El Dorado.
U.S. Route 59 (US-59) is a part of the U.S. Highway System that runs from the Mexico–US border in Laredo, Texas, as a continuation of Mexican Federal Highway 85D north to the Lancaster–Tolstoi Border Crossing on the Canada–US border, where it continues as Manitoba Highway 59. In the U.S. state of Kansas, US-59 is a main north–south highway that travels from Chetopa to Atchison.
Interstate 35 (I-35) is an Interstate Highway in the US that runs from the Mexican border near Laredo, Texas, to Duluth, Minnesota. In Kansas, the highway goes from the Oklahoma border to Kansas City at the Missouri border, with a length of 235 miles (378 km). Along the way, I-35 passes through Wichita, the state's largest city, linking it to Emporia, Ottawa, and Kansas City and its Johnson County suburbs. The section of the route from the Oklahoma border to I-335 is part of the Kansas Turnpike.
Lewis and Clark Trail 
I-29 / I-35 / US 71 in North Kansas City 
I-435 near Birmingham 
Route 10 southwest of Richmond 
