Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The highway travels from LaPlace, Louisiana, at I-10 to Chicago, Illinois, at U.S. Route 41, at McCormick Place. The major cities that I-55 connects to are New Orleans, Louisiana; Jackson, Mississippi; Memphis, Tennessee; St. Louis, Missouri; and Chicago, Illinois.
Route 100, also named Manchester Road through St. Louis County and Manchester Avenue and Chouteau Avenue through St. Louis City, is a state highway in the U.S. state of Missouri. It runs from Linn, Missouri at U.S. Route 50 to Interstate 55 in St. Louis. The highway is 121 miles (195 km) long.
Route 141, also known as Woods Mill Road in parts of St. Louis County, is a state highway located in the western St. Louis metropolitan area. Its northern terminus is at Route 370 in Bridgeton; its southern terminus is at U.S. Route 61/U.S. Route 67 in Arnold, in Jefferson County. The northern stretches of the highway are often referred to as the Maryland Heights Expressway or Earth City Expressway.
The Avenue of the Saints is a 563-mile-long (906 km) highway in the Midwestern United States that connects St. Louis, Missouri and St. Paul, Minnesota.
Ted Drewes is a family-owned frozen custard company in St. Louis, Missouri, United States. The business was founded by Ted Drewes, Sr. in 1929. The shop on Chippewa Street is open much of the year, while the South Grand Boulevard location is open from mid-May through late August.
Route 30 is a highway in eastern Missouri, United States. Its eastern terminus is at the Interstate 55/Interstate 44 junction in St. Louis. Its western terminus is at Interstate 44 in St. Clair. In St. Louis, the section between Interstate 44 and Route 366 is part of historic U.S. Route 66 and is marked as such. In the St. Louis area, it is known as Gravois Avenue or Gravois Road. Further south, Gravois Rd. is used to mark the old section of the highway where the newer, divided highway rerouted Highway 30.
Route 109 is a state highway in St. Louis County, Missouri and Jefferson County, Missouri. Its northern terminus is at Wild Horse Creek Road in Chesterfield; its southern terminus is at Routes W and FF in Jefferson County. The road continues north, curves around Spirit of St. Louis Airport and connects with Chesterfield Airport Road, providing a "backway" to the Chesterfield area.
U.S. Route 66 is a former east–west United States Numbered Highway, running from Santa Monica, California to Chicago, Illinois. In Missouri, the highway ran from downtown St. Louis at the Mississippi River to the Kansas state line west of Joplin. The highway was originally Route 14 from St. Louis to Joplin and Route 1F from Joplin to Kansas. It underwent two major realignments and several lesser realignments in the cities of St. Louis, Springfield, and Joplin. Current highways covering several miles of the former highway include Route 100, Route 366, Route 266, Route 96, and Route 66. Interstate 44 (I-44) approximates much of US 66 between St. Louis and Springfield.
Transportation in Greater St. Louis, Missouri includes road, rail, ship, and air transportation modes connecting the bi-state St. Louis metropolitan area with surrounding communities throughout the Midwest, national transportation networks, and international locations. The Greater St. Louis region also supports a multi-modal transportation network that includes bus, paratransit, and light rail service in addition to shared-use paths, bike lanes and greenways.
Interstate 55 (I-55) in the US state of Missouri runs from the Arkansas state line to the Poplar Street Bridge over the Mississippi River in St. Louis.
Interstate 70 (I-70) in the US state of Missouri is generally parallel to the Missouri River. This section of the transcontinental Interstate begins at the Kansas state line on the Intercity Viaduct, running concurrently with US Route 24 (US 24), US 40, and US 169, and the east end is on the Stan Musial Veterans Memorial Bridge in St. Louis.
U.S. Route 50 (US 50) is a major east–west route in the state of Missouri. It is also known as the Rex M. Whitton Expressway in the capital of Missouri, Jefferson City.
Interstate 64 (I-64) passes through the Greater St. Louis area in the US state of Missouri. The entire route is concurrent with U.S. Route 40 (US 40). Because the road was a main thoroughfare in the St. Louis area before the development of the Interstate Highway System, it is not uncommon for locals to refer to the stretch of highway as "Highway 40" rather than "I-64". On December 6, 2009, the portion of the highway running through the city of St. Louis was named the Jack Buck Memorial Highway in honor of the late sportscaster.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
There have been 22 special routes of U.S. Route 66.
The streets of St. Louis, Missouri, United States, and the surrounding area of Greater St. Louis are under the jurisdiction of the City of St. Louis Street Department. According to the Streets Division, there are 1,000-mile (1,600 km) of streets and 600-mile (970 km) of alleys within the city.
Jefferson Avenue is a major, seven lane wide, north to south thoroughfare in the city of St. Louis, Missouri. For much of its run in south city Jefferson Avenue and Grand Boulevard take a parallel course, separated by about sixteen blocks. In the northern city, their concurrence varies some.
U.S. Route 67 is the portion of a north-south highway in Missouri that starts at the Arkansas state line south of Neelyville and ends at the Illinois state line northeast of West Alton.
U.S. Highway 71 is a U.S. highway that runs from Krotz Springs, LA to the Fort Frances–International Falls International Bridge at the Canadian border. In Arkansas, the highway runs from the Louisiana state line near Doddridge to the Missouri state line near Bella Vista. In Texarkana, the highway runs along State Line Avenue with US 59 and partially runs in Texas. Other areas served by the highway include Fort Smith and Northwest Arkansas.
U.S. Route 40 (US 40) in the state of Missouri is a U.S. highway that runs from Kansas City to St. Louis. Outside of Greater St. Louis, much of the route either parallels or runs along I-70. East of Wentzville in Greater St. Louis, the route runs along I-64.
I-44 / I-270 / US 50 in Sunset Hills 
US 50 / US 61 / US 67 in Sunset Hills
