Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The highway travels from LaPlace, Louisiana, at I-10 to Chicago, Illinois, at U.S. Route 41, at McCormick Place. The major cities that I-55 connects to are New Orleans, Louisiana; Jackson, Mississippi; Memphis, Tennessee; St. Louis, Missouri; and Chicago, Illinois.
Interstate 44 (I-44) is an Interstate Highway in the central United States. Although it is nominally an east–west road as it is even-numbered, it follows a more southwest–northeast alignment. Its western terminus is in Wichita Falls, Texas, at a concurrency with U.S. Route 277 (US 277), US 281, and US 287; its eastern terminus is at I-70 in St. Louis, Missouri. I-44 is one of five Interstates built to bypass US 66; this highway covers the section between Oklahoma City and St. Louis. Virtually the entire length of I-44 east of Springfield, Missouri, was once US 66, which was upgraded from two to four lanes from 1949 to 1955. The section of I-44 west of Springfield was built farther south than US 66 in order to connect Missouri's section with the already completed Will Rogers Turnpike, which Oklahoma wished to carry their part of I-44.
Interstate 64 (I-64) is an east–west Interstate Highway in the Eastern United States. Its western terminus is at I-70, US Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at an interchange with I-264 and I-664 at Bower's Hill in Chesapeake, Virginia. I-64 connects the major metropolitan areas of St. Louis, Missouri; Louisville and Lexington in Kentucky; Charleston, West Virginia; and Richmond and Hampton Roads in Virginia.
U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35). Until 1991, the highway extended north on what is now Minnesota State Highway 61 through Duluth to the Canada–U.S. border near Grand Portage. Its southern terminus in New Orleans is at an intersection with U.S. Route 90. The route was an important south–north connection in the days before the interstate highway system.
Route 100, also named Manchester Road through St. Louis County and Manchester Avenue and Chouteau Avenue through St. Louis City, is a state highway in the U.S. state of Missouri. It runs from Linn, Missouri at U.S. Route 50 to Interstate 55 in St. Louis. The highway is 121 miles (195 km) long.
U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa. US 67 crosses the Mississippi River twice along its routing. The first crossing is at West Alton, Missouri, where US 67 uses the Clark Bridge to reach Alton, Illinois. About 240 miles (390 km) to the north, US 67 crosses the river again at the Rock Island Centennial Bridge between Rock Island, Illinois, and Davenport, Iowa. Additionally, the route crosses the Missouri River via the Lewis Bridge a few miles southwest of the Clark Bridge.
U.S. Route 60 is a major east–west United States highway, traveling 2,655 miles (4,273 km) from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as Pacific Avenue, in the city's Oceanfront resort district at the intersection of 5th Street and Winston-Salem Avenue. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California, but in 1964, it was truncated to end southwest of Brenda, Arizona, at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. I-10 replaced US 60 from Beaumont, California, to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.
Interstate 170 (I-170), also known as the Inner Belt Expressway, is an 11.17-mile (17.98 km) north–south auxiliary Interstate Highway in Greater St. Louis, Missouri. I-170 connects to I-270 at its northern terminus and I-64 at its southern terminus. I-170 crosses its parent, I-70, near St. Louis Lambert International Airport.
Interstate 255 (I-255) is a bypass route of I-55 in Greater St. Louis. Along with I-270, it forms a loop around the central portion of the bi-state metro area; a majority of I-255 is located on the Illinois half. It shares its southern terminus with I-270 at the junction with I-55; I-270 and I-255 go to the west and east, respectively. U.S. Route 50 (US 50) joins I-255 at Lemay Ferry Road. It crosses the Mississippi River on the Jefferson Barracks Bridge, enters Illinois, and then turns northeast. There is a junction with I-64, where US 50 breaks off and goes east, and then further north there is a junction with I-55 again, I-70, and US 40, all of which are all cosigned together. The next junction is another one with I-270, which is the northern terminus of I-255. After that, the limited-access freeway continues on as Illinois Route 255 (IL 255). I-255 is 30.82 miles (49.60 km) in length.
Route 364, known locally as the Page Extension, the Page Avenue Freeway, the Page Expressway, or simply the Extension, is a freeway that connects St. Louis County in Maryland Heights with St. Charles County in Lake St. Louis via the Veterans Memorial Bridge over the Missouri River. The highway is a designated auxiliary state route of I-64.
Route 366 is a highway located completely within the St. Louis metropolitan area. It is primarily a former section of U.S. Route 66. Beginning at South Broadway/South Jefferson Avenue in St. Louis and ending at the Interstate 44/Interstate 270 interchange in Sunset Hills, it was established in 1979 when US 66 was decertified between Chicago, Illinois and Joplin, Missouri.
Interstate 270 (I-270) makes up a large portion of the outer belt freeway in Greater St. Louis. The counterclockwise terminus of I-270 is at the junction with I-55 and I-255 in Mehlville, Missouri; the clockwise terminus of the freeway is at the junction with I-55 and I-70 north of Troy, Illinois. The entire stretch of I-270 is 50.59 miles (81.42 km).
Route 755 was a proposed state highway entirely in the city limits of St. Louis, Missouri, that was never built due to local objections. Its northern terminus was to be at an interchange with Interstate 70 (I-70) in the northeastern part of the city and its southern terminus was at an interchange with I-44/I-55. It would have had an interchange with I-64/U.S. Route 40 along the way. The road was proposed as a freeway bypassing the downtown area of St. Louis and would have provided the currently missing connections of northbound I-44/I-55 to westbound I-64 and eastbound I-64 to westbound I-44/I-55 or westbound I-70. It also was to be signed Interstate 755, or I-755.
Transportation in Greater St. Louis, Missouri includes road, rail, ship, and air transportation modes connecting the bi-state St. Louis metropolitan area with surrounding communities throughout the Midwest, national transportation networks, and international locations. The Greater St. Louis region also supports a multi-modal transportation network that includes bus, paratransit, and light rail service in addition to shared-use paths, bike lanes and greenways.
Interstate 55 (I-55) is a major north–south Interstate Highway in the US state of Illinois that connects St. Louis, Missouri, to the Chicago metropolitan area. It enters the state from Missouri near East St. Louis, Illinois, and runs to U.S. Route 41 near Downtown Chicago, where the highway ends, a distance of 294.38 miles (473.76 km). The road also runs through the Illinois cities of Springfield, Bloomington, and Joliet. The section in Cook County is officially named the Stevenson Expressway, and in DuPage County its officially named the Joliet Freeway or the Will Rogers Freeway. The section from the south suburbs of Chicago to the area near Pontiac is officially named the Barack Obama Presidential Expressway after the 44th President, Barack Obama, who launched his political career from Illinois.
Interstate 64 (I-64) passes through the Greater St. Louis area in the US state of Missouri. The entire route is concurrent with U.S. Route 40 (US 40). Because the road was a main thoroughfare in the St. Louis area before the development of the Interstate Highway System, it is not uncommon for locals to refer to the stretch of highway as "Highway 40" rather than "I-64". On December 6, 2009, the portion of the highway running through the city of St. Louis was named the Jack Buck Memorial Highway in honor of the late sportscaster.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
James River Freeway is a 14-mile-long (23 km) freeway located largely on the south side of Springfield, Missouri. Its western terminus is at Interstate 44 (I-44) north of Brookline and its eastern terminus is at U.S. Route 65 (US 65) in southeastern Springfield. It is named for the James River, which passes near the highway at the freeway's eastern terminus. A total of four highways are routed on the highway: Route 360, US 60, US 160, Route 13, and Business US 65.
There have been 22 special routes of U.S. Route 66.
U.S. Route 67 is the portion of a north-south highway in Missouri that starts at the Arkansas state line south of Neelyville and ends at the Illinois state line northeast of West Alton.
I-44 in St. Clair 
I-44 / I-55 in St. Louis 
