Route 43 is a highway in western Missouri. Its northern terminus is at U.S. Route 54 midway between Nevada and Deerfield. Its southern terminus is at the corner of Missouri, Arkansas, and Oklahoma where it continues down the Arkansas/Oklahoma state line as both Arkansas Highway 43 and Oklahoma State Highway 20.
Route 86 is a highway in southwest Missouri. The eastern terminus is at U.S. Route 65 just north of Ridgedale. From there, the road crosses the Long Creek arm of Table Rock Lake and continues to Blue Eye west between the Arkansas state line on the south and Table Rock Lake on the north. This section is also in the Mark Twain National Forest, and is recommended as a scenic drive by the Missouri Department of Transportation. From Eagle Rock the road turns north to join with Route 76 at Bates Corner with which it is runs concurrent through Cassville to just east of Rocky Comfort. The road continues north and west towards Neosho, then goes further west before turning north towards Joplin where the road ends at the interchange of Interstate 44 and Route 43. Except for a short section in Neosho, the road is a two-lane highway for its entire length.
Route 39 is a two-lane highway in southwestern Missouri. Its northern terminus is at U.S. Route 54 between Collins and El Dorado Springs at the community of Cedar Springs; its southern terminus is at the Arkansas state line where it continues as Highway 221.
Route 142 is a highway in southern Missouri. Its eastern terminus is at Route 53 in southern Poplar Bluff; its western terminus is at Route 101 in Bakersfield. Route 142 is the southernmost east–west highway in the south-central part of the state. Despite its length, there are relatively few towns on the route.
Route 21 is a highway in eastern Missouri. Its northern terminus is at Route 30 in Affton. Its southern terminus is at the Arkansas state line. In the St. Louis area, it is known as Tesson Ferry Road, which was named after the 19th century proprietor of the ferry across the Meramec River.
Route 224 is a highway in western Missouri. Its eastern terminus is at U.S. Route 24 near Lexington; its western terminus is at US 24 west of Napoleon. It follows the Missouri River and is prone to flooding.
Route 116 is a highway in northwestern Missouri. Its eastern terminus is at Route A in Braymer; its western terminus is at U.S. Route 59 in Rushville.
Route 248 is a highway in southwestern Missouri. Its eastern terminus is at U.S. Route 65 in Branson. Its western terminus is at Route 76/Route 86/Route 112 in Cassville.
Route 133 is a highway in central Missouri. Its northern terminus is at U.S. Route 63 near Westphalia; its southern terminus is at Interstate 44 about fourteen miles (21 km) west of Waynesville.
Route 51 is a highway in southeastern Missouri. Its northern terminus is the Illinois state line near Chester, Illinois; its southern terminus is at the Arkansas state line northwest of Piggott, Arkansas. It continues into Illinois as Illinois Route 150 and it continues into Arkansas as Highway 139.
Route 34 is a highway in southeastern Missouri. Its eastern terminus is at the Illinois state line on the Mississippi River at Cape Girardeau where it overlaps Route 74. Its western terminus is at U.S. Route 60 near Van Buren. The road continues into Illinois as Illinois Route 146.
Route 58 is a highway in western Missouri. Its eastern terminus is at U.S. Route 50 west of Warrensburg; its western terminus is at Route D west of Belton, Missouri. It is one of only a very few highways to end at a state supplemental route.
Route 114 is a highway in southeastern Missouri. Its eastern terminus is at Business U.S. Route 60 west of Sikeston; its western terminus is at Route 25 in Dexter.
Route 41 is a highway in central Missouri. Its northern terminus is at U.S. Route 24 in southern Carroll County; its southern terminus is at Interstate 70/U.S. Route 40 west of Boonville, where the road continues south as Route 135.
Route 33 is a highway in western Missouri. Its northern terminus is at Route 6 in Maysville; its southern terminus is at U.S. Route 69 in Liberty.
Route 47 is a highway in eastern Missouri. Its northern terminus is at Route 79 near Winfield; its southern terminus is at U.S. Route 67 in Bonne Terre.
Route 82 is a highway in southwest Missouri. Its eastern terminus is at Route 83 in northwest Hickory County; its western terminus is at U.S. Route 54 in El Dorado Springs.
Route 154 is a highway in northeastern Missouri. Its eastern terminus is at U.S. Route 54 north of Vandalia; its western terminus is at U.S. Route 24) west of Paris, where Business US 24 also has its western terminus. Route 154 passes through Mark Twain State Park and over Mark Twain Lake.
Route 88 was a 6.8-mile-long (10.9 km) state highway located entirely within the city limits of Springfield. Its western terminus was at Sunshine Street. Its eastern terminus was at Glenstone Avenue. It was a collection of older highways which were still under state maintenance.
U.S. Route 169 (US-169) is a major north–south U.S. Highway that runs from US-64 in Tulsa, Oklahoma, to US-53 near Virginia, Minnesota. In Kansas, the highway is a main north–south route that runs through the eastern end of the state from the Oklahoma border to Missouri border. Along the way US-169 intersects several major highways including US-400 by Cherryvale, US-54 by Iola, overlaps US-59 south of Garnett, overlaps I-35 from Olathe to Merriam, and in Kansas City begins an overlap with I-70, US-24 and US-40 which it follows into Missouri.
Route 25 in Holcomb 
US 62 in Campbell 
US 67 Bus. in Poplar Bluff 
