Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The highway travels from LaPlace, Louisiana, at I-10 to Chicago, Illinois, at U.S. Route 41, at McCormick Place. The major cities that I-55 connects to are New Orleans, Louisiana; Jackson, Mississippi; Memphis, Tennessee; St. Louis, Missouri; and Chicago, Illinois.
U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35). Until 1991, the highway extended north on what is now Minnesota State Highway 61 through Duluth to the Canada–U.S. border near Grand Portage. Its southern terminus in New Orleans is at an intersection with U.S. Route 90. The route was an important south–north connection in the days before the interstate highway system.
U.S. Route 49 is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel. Despite its numbering it is not associated with U.S. Route 12.
U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa. US 67 crosses the Mississippi River twice along its routing. The first crossing is at West Alton, Missouri, where US 67 uses the Clark Bridge to reach Alton, Illinois. About 240 miles (390 km) to the north, US 67 crosses the river again at the Rock Island Centennial Bridge between Rock Island, Illinois, and Davenport, Iowa. Additionally, the route crosses the Missouri River via the Lewis Bridge a few miles southwest of the Clark Bridge.
U.S. Route 59 is a north–south United States highway. A latecomer to the U.S. numbered route system, US 59 is now a border-to-border route, part of the NAFTA Corridor Highway System. It parallels U.S. Route 75 for nearly its entire route, never much more than 100 miles (160 km) away, until it veers southwest in Houston, Texas. Its number is out of place since US 59 is either concurrent with or entirely west of U.S. Route 71. The highway's northern terminus is 9 mi (14 km) north of Lancaster, Minnesota, at the Lancaster–Tolstoi Border Crossing on the Canada–US border, where it continues as Manitoba Highway 59. Its southern terminus is at the Mexico–US border in Laredo, Texas, where it continues as Mexican Federal Highway 85D.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 65 is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S. Route 425 in Clayton, Louisiana. The northern terminus is at Interstate 35 just south of Interstate 90 in Albert Lea, Minnesota. Parts of its modern route in Iowa and historic route in Minnesota follow the old Jefferson Highway.
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
Route 21 is a highway in eastern Missouri. Its northern terminus is at Route 30 in Affton. Its southern terminus is at the Arkansas state line. In the St. Louis area, it is known as Tesson Ferry Road, which was named after the 19th century proprietor of the ferry across the Meramec River.
Route 164 is a state highway in the Missouri Bootheel. The route starts at U.S. Route 412 in Cardwell. The route travels eastward across the bootheel, and it goes through the towns of Arbyrd, Hornersville, Rives, and Steele. It becomes concurrent with US 61 briefly in Steele, and intersects Interstate 55 (I-55) east of the city. The route ends east of Cottonwood Point, near the Mississippi River.
Route 108 is a short highway in the Bootheel of southeastern Missouri. Its eastern terminus is the Arkansas state line at Arkansas Highway 77, about six miles (10 km) south of Arbyrd, the only town on the route. Its western terminus is at U.S. Route 412 (US 412) about two miles (3 km) north of Arbyrd. Although signed as an east–west route, the route follows mostly north–south roadways. The route was designated in 1930, and was extended east in 1972.
Arkansas Highway 25 is a northeast–southwest state highway in north central Arkansas. The route runs 85.66 miles (137.86 km) from US 64 in Conway to US 63/412 in Black Rock through Greers Ferry, Batesville, and the foothills of The Ozarks.
State Highway 10 is a state highway in northeastern Oklahoma. It makes a 233.1 miles (375.1 km) crescent through the northeast corner of the state, running from SH-99 in Osage County to Interstate 40 (I-40) near Gore. It has two lettered spur routes.
A total of ten special routes of U.S. Route 71 exist, and another ten previously existed.
U.S. Route 62 is a U.S. highway running from El Paso, Texas northeast to Niagara Falls, New York. In the U.S. state of Arkansas, the route runs 329.9 miles from the Oklahoma border near Summers east to the Missouri border in St. Francis, serving the northern portion of the state. The route passes through several cities and towns, including Fayetteville, Springdale, Bentonville, Harrison, Mountain Home, Pocahontas, and also Piggott. US 62 runs concurrent with several highways in Arkansas including Interstate 49 and U.S. Route 71 between Fayetteville and Bentonville, U.S. Route 412 through much of the state, U.S. Route 65 in the Harrison area, and with U.S. Route 63 and U.S. Route 67 in northeast Arkansas.
Route 84 is a state highway in the Missouri bootheel. The route starts at Arkansas Highway 90 over the St. Francis River on the Arkansas–Missouri state line. The road travels eastward to Kennett, where it becomes concurrent with U.S. Route 412. East of Kennett, the concurrent routes travel eastward on a divided highway to Hayti Heights, where the concurrency ends. Route 84 travels through Hayti Heights and Hayti, and it crosses Interstate 55 (I-55) and US 61. The route then travels southeastwards to Caruthersville, and bypasses the central area of the city. In the southern part of Caruthersville, Route 84 ends at an interchange with I-155 and US 412.
A total of eight special routes of U.S. Route 65 exist, divided between the U.S. states of Arkansas and Missouri. Currently, they are all business loops, although a spur route in Pine Bluff, Arkansas and bypass routes in Baton Rouge, Louisiana and Springfield, Missouri both existed in the past.
Six special routes of U.S. Route 412 exist.
U.S. Route 67 is the portion of a north-south highway in Missouri that starts at the Arkansas state line south of Neelyville and ends at the Illinois state line northeast of West Alton.
I-55 BL / US 61 / Route 34 / Route 72 in Jackson 
US 412 / Route 84 in Kennett 
