Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The highway travels from LaPlace, Louisiana, at I-10 to Chicago, Illinois, at U.S. Route 41, at McCormick Place. The major cities that I-55 connects to are New Orleans, Louisiana; Jackson, Mississippi; Memphis, Tennessee; St. Louis, Missouri; and Chicago, Illinois.
Interstate 57 (I-57) is a north–south Interstate Highway in Missouri and Illinois that parallels the old Illinois Central Railroad for much of its route. It runs from Sikeston, Missouri, at I-55 to Chicago, Illinois, at I-94. I-57 essentially serves as a shortcut route for travelers headed between the South and Chicago, bypassing St. Louis, Missouri and Springfield, Illinois. Between the junction of I-55 and I-57 in Sikeston and the junction of I-55 and I-90/I-94 in Chicago, I-55 travels for 436 miles (702 km), while the combination of I-57 and I-94 is only 396 miles (637 km) long between the same two points. In fact, both the control cities on the overhead signs and the destination mileage signs reference Memphis along southbound I-57, even as far north as its northern origin at I-94 in Chicago. Likewise, at its southern end, Chicago is the control city listed for I-57 on signs on northbound I-55 south of Sikeston, even though I-55 also goes to Chicago. A southward extension of I-57 from its current southern terminus to Little Rock, Arkansas is currently in various stages of development.
Interstate 72 (I-72) is an Interstate Highway in the midwestern United States. Its western terminus is in Hannibal, Missouri, at an intersection with U.S. Route 61 (US 61); its eastern terminus is at Country Fair Drive in Champaign, Illinois. The route runs through the major cities of Decatur, Illinois, and Springfield, Illinois. In 2006, the Illinois General Assembly dedicated all of I-72 as Purple Heart Memorial Highway. The stretch between Springfield and Decatur is also called Penny Severns Memorial Expressway, and the section between mile 35 and the Mississippi River is known as the Free Frank McWorter Historic Highway.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route.
U.S. Route 136 is an east-west U.S. highway that is a spur route of U.S. Route 36. It runs from Edison, Nebraska, at U.S. Route 6 and U.S. Route 34 to the Interstate 74/Interstate 465 interchange in Speedway, Indiana. This is a distance of 804 miles (1,294 km). Due to the removal of almost every numbered route in Indianapolis, US 136 never meets its parent, US 36; however, it does come within two miles of it at its interchange with I-465/I-74 at its eastern terminus.
Route 43 is a highway in western Missouri. Its northern terminus is at U.S. Route 54 midway between Nevada and Deerfield. Its southern terminus is at the corner of Missouri, Arkansas, and Oklahoma where it continues down the Arkansas/Oklahoma state line as both Arkansas Highway 43 and Oklahoma State Highway 20.
Route 51 is a highway in southeastern Missouri. Its northern terminus is the Illinois state line near Chester, Illinois; its southern terminus is at the Arkansas state line northwest of Piggott, Arkansas. It continues into Illinois as Illinois Route 150 and it continues into Arkansas as Highway 139.
Route 34 is a highway in southeastern Missouri. Its eastern terminus is at the Illinois state line on the Mississippi River at Cape Girardeau where it overlaps Route 74. Its western terminus is at U.S. Route 60 near Van Buren. The road continues into Illinois as Illinois Route 146.
Route 177 is a highway in Cape Girardeau County, Missouri, USA. Its northern terminus is at U.S. Route 61 at Fruitland, Missouri; its southern terminus is at Route 34/Route 74 in Cape Girardeau.
Route 129 is a highway in northern and central Missouri. Its northern terminus is at the Iowa state line where it continues as Appanoose County Road T20; its southern terminus is at Route 3 in Roanoke.
Route 41 is a highway in central Missouri. Its northern terminus is at U.S. Route 24 in southern Carroll County; its southern terminus is at Interstate 70/U.S. Route 40 west of Boonville, where the road continues south as Route 135.
Route 119 is a highway in Dent County. Its northern terminus is at Route 32 southwest of Salem; its southern terminus is at Montauk State Park. There are no towns on the highway.
Interstate 155 (I-155) is an east–west auxiliary route of Interstate 55 (I-55) that runs through the Bootheel of Missouri and the northwestern corner of Tennessee. It begins south of Hayti, Missouri at I-55, passes eastward through Caruthersville, and crosses the Mississippi River on the Caruthersville Bridge into Tennessee. The route then proceeds to Dyersburg, Tennessee, where it terminates at U.S. Route 51 (US 51). I-155 is the only road that directly connects Missouri and Tennessee, and is concurrent with US 412 for its entire length.
State Road 32 (SR 32) in the U.S. state of Indiana is an east–west state highway in central Indiana that crosses the entire state, covering a distance of about 157 miles (253 km). The western terminus of SR 32 is at the Illinois state line, southeast of Danville, Illinois, where the state highway becomes a county road. The eastern terminus is at Union City, Indiana, and Union City, Ohio, at the Ohio state border where the highway becomes Ohio State Route 47.
Route 88 was a 6.8-mile-long (10.9 km) state highway located entirely within the city limits of Springfield. Its western terminus was at Sunshine Street. Its eastern terminus was at Glenstone Avenue. It was a collection of older highways which were still under state maintenance.
Interstate 66 (I-66) is a canceled Interstate Highway designated in the Intermodal Surface Transportation Efficiency Act (ISTEA) of 1991 as the East–West TransAmerica Corridor and High Priority Corridor 3. The US Department of Transportation originally planned to extend the current I-66 from its western terminus at Middletown, Virginia, across the country to California. The route west of Kansas was not favored by any of the related state highway departments, and, as a result, I-66 west of Wichita, Kansas, through New Mexico, Arizona, Nevada and California was canceled. Among the reasons for this were lack of interest from any of the state highway departments, and the insufficient projected traffic did not justify an Interstate, especially since many segments had no preexisting highway. The National Park Service was strongly opposed to building I-66 across the Death Valley National Park. The choice for the number I-66 was a hope to capitalize on name association with the decommissioned US Route 66 (US 66). The case for westward expansion of I-66 was started by businesspeople in Wichita. Furthermore, there were no plans to build I-66 across the West Virginia–Virginia state line, leaving it as a non-contiguous highway. The I-66 concept was supported in Kentucky mainly because of the efforts of Representative Hal Rogers; however, the Kentucky Transportation Cabinet (KYTC) completed its feasibility study in 2005 and concluded that building I-66 was too costly and of little traffic benefit with high potential environmental impact and canceled the project in that state. The only remaining study of I-66 was conducted by the Federal Highway Administration (FHWA) and the Illinois Department of Transportation (IDOT) under the 66 Corridor Study, a Tier 1 environmental impact statement (EIS). This study was canceled August 6, 2015, by IDOT, and, subsequently, the FHWA announced the cancellation of the EIS in the Federal Register, ending the last I-66 project and therefore officially canceling the I-66 Trans America Highway.
Interstate 55 (I-55) in the US state of Missouri runs from the Arkansas state line to the Poplar Street Bridge over the Mississippi River in St. Louis.
U.S. Highway 76 (US 76) is a U.S. Highway running from Chattanooga, Tennessee to Wrightsville Beach, North Carolina. In North Carolina the highway runs for 80.4 miles (129.4 km) in the southeastern region of the state. US 76 enters the state from South Carolina south of Fair Bluff in Columbus County. Travelling in an eastward direction, US 76 meets US 74 in Chadbourn. The two highways run concurrently for 50.4 miles (81.1 km) between Chadbourn and Wilmington. US 76 runs concurrently with US 17 along much of its Wilmington routing, until once again meeting US 74. US 76 and US 74 run concurrently for 1.4 miles (2.3 km) until reaching Wrightsville Beach. US 76 reaches its eastern terminus on the south side of Wrightsville Beach, at an intersection with Water Street.
The Chicago–Kansas City Expressway is a highway that runs between Chicago, Illinois, and Kansas City, Missouri. The road is known as Route 110 in Missouri and Illinois Route 110 (IL 110) in Illinois. IL 110 was created through legislation on May 27, 2010, as the designated route for the Illinois portion of the Chicago–Kansas City Expressway.
Interstate business routes are roads connecting a central or commercial district of a city or town with an Interstate bypass. These roads typically follow along local streets often along a former U.S. Route or state highway that had been replaced by an Interstate. Interstate business route reassurance markers are signed as either loops or spurs using a green shield shaped sign and numbered like the shield of the parent Interstate highway.
Route 25 in Dutchtown 
IL 146 at the Illinois state line
