U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8.0 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri. Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song "Wolf Creek Pass".
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
Route 37 is a highway in southwest Missouri. Its northern terminus is at U.S. Route 160 in Golden City ; its southern terminus is at the Arkansas state line where it continues as Highway 37, though it only runs very briefly before ending at U.S. Route 62 in Gateway, Arkansas.
Route 97 is a highway in southwest Missouri. Its northern terminus is at Route 32 eight miles (13 km) south of El Dorado Springs; its southern terminus is at Route 86, four miles north of Wheaton.
Route 32 is a highway in Missouri. Its eastern terminus is at the Mississippi River near Ste. Genevieve; its western terminus is at U.S. Route 54 in El Dorado Springs. It is currently one of the longest highways in the state. Most of the highway east of Lebanon is hilly and curvy, passing through a large part of the Missouri Ozarks.
Route 172 is a state highway in the Mark Twain National Forest, specifically in Wayne County, Missouri. The route runs for 8.97 miles (14.44 km) eastward as a two-lane highway through dense forests. Route 172 begins at an intersection with U.S. Route 67 just south of the intersection nearby with Route 49. Route 172 has a mile-long concurrency midway with Supplemental Route W, where the Route 172 returns to its eastern terminus, Lake Wappapello State Park. The route does not pass any communities or municipalities on its stretch.
State Trunk Highway 54 is a Wisconsin state highway running east–west across central Wisconsin. It is 243.12 miles (391.26 km) in length.
U.S. Route 136 (US 136) runs east–west across central Illinois for 225.5 miles (362.9 km). US 136 enters the state from Iowa across the Keokuk–Hamilton Bridge over the Mississippi River between Keokuk, Iowa, and Hamilton, Illinois, and exits into Indiana east of Danville. The largest population centers along the route are Macomb, Rantoul, and Danville.
Pennsylvania Route 88 is a 68-mile-long (109 km) north–south state highway located in southwestern Pennsylvania. The southern terminus of the route is at U.S. Route 119 (US 119) in Point Marion less than 2 miles (3 km) from the Pennsylvania-West Virginia border. The northern terminus is at PA 51 in Pittsburgh. PA 88 runs parallel to the Monongahela River for almost its entire length.
State Route 41 (SR 41) is a 134.5-mile-long (216.5 km) state highway that runs south-to-north through portions of Calhoun, Randolph, Terrell, Webster, Marion, Talbot, Meriwether, and Coweta counties in the southwestern and west-central parts of the U.S. state of Georgia. The route connects the Morgan area to Moreland, via Buena Vista, Manchester, Warm Springs, and Greenville.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
Arkansas Highway 242 is an east–west state highway in Phillips County, Arkansas. The route of 14.74 miles (23.72 km) runs from Highway 44 near Helena-West Helena north through the city and through the St. Francis National Forest to Highway 1 near Lexa. A segment of the route is part of the Mississippi River Trail, essentially a bicycle-friendly version of the Great River Road.
Highway 94 is an east–west state highway in Benton County, Arkansas. The route of 22.07 miles (35.52 km) runs from Horseshoe Bend Park near Beaver Lake west across US Route 71 Business (US 71B) and US 62 to Missouri Supplemental Route E at the Missouri state line. The route is maintained by the Arkansas State Highway and Transportation Department (AHTD).
Arkansas Highway 279 is a north–south state highway in Benton County, Arkansas. The route runs 14.87 miles (23.93 km) from Arkansas Highway 12 at Vaughn north to the Missouri state line through Centerton. The route has a rare officially designated exception of 0.52 miles (0.84 km), overlapping Arkansas Highway 72.
State Route 48 (SR 48) is a long north–south state highway in Middle Tennessee. It traverses six counties, and it is 103.86 miles (167.15 km) long.
U.S. Route 54 in Missouri is a west-east highway that runs between the Kansas state line in Nevada, Missouri and the Illinois state line in Louisiana, Missouri.
U.S. Route 63 is the portion of a north-south highway that runs through the U.S. state of Missouri from the Arkansas state line near Thayer to the Iowa state line near Lancaster.
I-44 BL in Rolla 
I-55 BL / US 61 / Route 25 in Jackson 
