U.S. Route 400 is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada, Colorado, at an intersection with US 385. The highway's eastern terminus is southwest of Joplin, Missouri, near Loma Linda, at an interchange with Interstate 44, with which it shares with US 166. It originally ended in Garden City, Kansas; in 1996 it was extended to its current western terminus.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel. Despite its numbering it is not associated with U.S. Route 12.
U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8.0 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri. Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song "Wolf Creek Pass".
U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S. Route 66, since US 666 was renumbered to US 491 in 2003.
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
Route 96 is a state highway that travels from Route 171 near Carl Junction, in Jasper County, to Interstate 44 (I-44) in Halltown, in Lawrence County. A large section of the highway between Carthage and Halltown served as part of U.S. Route 66 (US 66) and is currently marked as Historic Route 66.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
Route 37 is a highway in southwest Missouri. Its northern terminus is at U.S. Route 160 in Golden City ; its southern terminus is at the Arkansas state line where it continues as Highway 37, though it only runs very briefly before ending at U.S. Route 62 in Gateway, Arkansas.
Route 97 is a highway in southwest Missouri. Its northern terminus is at Route 32 eight miles (13 km) south of El Dorado Springs; its southern terminus is at Route 86, four miles north of Wheaton.
Route 32 is a highway in Missouri. Its eastern terminus is at the Mississippi River near Ste. Genevieve; its western terminus is at U.S. Route 54 in El Dorado Springs. It is currently one of the longest highways in the state. Most of the highway east of Lebanon is hilly and curvy, passing through a large part of the Missouri Ozarks.
Route 47 is a highway in eastern Missouri. Its northern terminus is at Route 79 near Winfield; its southern terminus is at U.S. Route 67 in Bonne Terre.
State Trunk Highway 54 is a Wisconsin state highway running east–west across central Wisconsin. It is 243.12 miles (391.26 km) in length.
Massachusetts Route 32 is a state highway in the U.S. state of Massachusetts. The highway runs 60.66 miles (97.62 km) from the Connecticut state line in Monson, where the highway continues as Connecticut Route 32, north to the New Hampshire state line in Royalston, where the highway continues as New Hampshire Route 32. Route 32 connects several towns on the eastern edge of Western Massachusetts. The highway serves Palmer in eastern Hampden County, Ware in eastern Hampshire County, and Barre and Athol in northwestern Worcester County. Route 32 intersects major east–west routes including U.S. Route 20 and the Massachusetts Turnpike in Palmer, Route 9 in Ware, and US 202 and Route 2 in Athol. The highway has an alternate route, Route 32A, through Hardwick and Petersham.
Pennsylvania Route 88 is a 68-mile-long (109 km) north–south state highway located in southwestern Pennsylvania. The southern terminus of the route is at U.S. Route 119 (US 119) in Point Marion less than 2 miles (3 km) from the Pennsylvania-West Virginia border. The northern terminus is at PA 51 in Pittsburgh. PA 88 runs parallel to the Monongahela River for almost its entire length.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
Arkansas Highway 242 is an east–west state highway in Phillips County, Arkansas. The route of 14.74 miles (23.72 km) runs from Highway 44 near Helena-West Helena north through the city and through the St. Francis National Forest to Highway 1 near Lexa. A segment of the route is part of the Mississippi River Trail, essentially a bicycle-friendly version of the Great River Road.
Arkansas Highway 279 is a north–south state highway in Benton County, Arkansas. The route runs 14.87 miles (23.93 km) from Arkansas Highway 12 at Vaughn north to the Missouri state line through Centerton. The route has a rare officially designated exception of 0.52 miles (0.84 km), overlapping Arkansas Highway 72.
U.S. Route 54 in Missouri is a west-east highway that starts from the Kansas state line in Nevada to the Illinois state line in Louisiana.
U.S. Route 63 is the portion of a north-south highway that runs through the U.S. state of Missouri from the Arkansas state line near Thayer to the Iowa state line near Lancaster.
I-44 BL in Rolla 
I-55 BL / US 61 / Route 25 in Jackson 
