Interstate 44 (I-44) is a major Interstate Highway in the central United States. Although it is nominally an east–west road as it is even-numbered, it follows a more southwest–northeast alignment. Its western terminus is in Wichita Falls, Texas, at a concurrency with U.S. Route 277 (US 277), US 281, and US 287; its eastern terminus is at I-70 in St. Louis, Missouri. I-44 is one of five Interstates built to bypass US 66; this highway covers the section between Oklahoma City and St. Louis. Virtually the entire length of I-44 east of Springfield, Missouri, was once US 66, which was upgraded from two to four lanes from 1949 to 1955. The section of I-44 west of Springfield was built farther south than US 66 in order to connect Missouri's section with the already completed Will Rogers Turnpike, which Oklahoma wished to carry their part of I-44.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel. Despite its numbering it is not associated with U.S. Route 12.
U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route.
U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miami, was US 94. The highway's southern terminus is in the Brickell neighborhood of Downtown Miami at an intersection with Brickell Avenue (US 1), and its northern terminus is east of Copper Harbor, Michigan, at a modest cul-de-sac near Fort Wilkins Historic State Park at the tip of the Keweenaw Peninsula. US 41 closely parallels Interstate 75 (I-75) from Naples, Florida, all the way through Georgia to Chattanooga, Tennessee.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 23 or U.S. Highway 23 (US 23) is a major north–south United States Numbered Highway between Jacksonville, Florida, and Mackinaw City, Michigan. It is an original 1926 route which originally reached only as far south as Portsmouth, Ohio, and has since been extended. It was formerly part of the major highway known as the Dixie Highway. The highway's southern terminus is in Jacksonville, Florida, at US 1/US 17. The northern terminus is at Interstate 75 (I-75) in Mackinaw City, Michigan.
U.S. Route 34 (US 34) is an east–west United States highway that runs for 1,122 miles (1,806 km) from north-central Colorado to the western suburbs of Chicago. Through Rocky Mountain National Park it is known as the Trail Ridge Road where it reaches elevation 12,183 feet (3,713 m), making it the third highest paved through highway in the United States. The highway's western terminus is Granby, Colorado at US 40. Its eastern terminus is in Berwyn, Illinois at Illinois Route 43 and Historic US 66.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route.
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
Missouri Route 5 is the longest state highway in Missouri and the only Missouri state highway to traverse the entire state. It is part of a three state, 650 mile highway 5. To the north, it continues into Iowa as Iowa Highway 5 and to the south it enters Arkansas as Arkansas Highway 5. With only a few exceptions, it is two-lane for its entire length. Business Route 5 serves Milan and Ava. There is Business Route 5 in Camdenton.
Kentucky Route 55 is a 140.858-mile-long (226.689 km) state highway in the U.S. Commonwealth of Kentucky.
U.S. Route 60 (US 60) is a major U.S. Highway in the American state of Kentucky. In the early days of the U.S. Highway System, US 60 was originally to be numbered as US 62. Following extensive lobbying and complaints filed by Kentucky governor William J. Fields to the American Association of State Highway Officials, the route was re-designated as US 60 before the system was finalized. In Kentucky, US 60 parallels the Ohio River. US 60 enters Kentucky from Cairo, Illinois, traveling northeast to Louisville, then takes a direct eastward route to rejoin the Ohio River in downtown Ashland, Kentucky. Both US 60 and US 23 run concurrently from Ashland to Catlettsburg where US 60 turns east and enters Kenova, West Virginia. US 60 is the longest route in Kentucky, running 495 miles (797 km) across the width of the state, passing through 22 of Kentucky's counties and through the cities of Paducah, Henderson, Owensboro, Louisville, the state capital of Frankfort, and Lexington.
Pennsylvania Route 51 is a major state highway that is located in Western Pennsylvania in the United States. It runs for 89 miles (143 km) from Uniontown to the Ohio state line near Darlington, where it connects with Ohio State Route 14.
State Route 49 (SR 49) is a 122.8-mile-long (197.6 km) state highway that travels southwest-to-northeast through portions of Terrell, Sumter, Macon, Peach, Houston, Bibb, Jones, and Baldwin counties, mainly in the central part of the U.S. state of Georgia. The highway connects SR 45 north of Dawson to SR 22/SR 24 in Milledgeville.
U.S. Route 50 (US 50) is a part of the U.S. Highway System that travels from West Sacramento, California, to Ocean City, Maryland. In the U.S. state of Colorado, US 50 is a major highway crossing through the lower midsection of the state. It connects the Western Slope with the lower Front Range and the Arkansas Valley. The highway serves the areas of Pueblo and Grand Junction as well as many other smaller areas along its corridor. The long-term project to widen the highway from two lanes to a four lane expressway between Grand Junction and Montrose was completed in January 2005. Only about 25% of the remainder of highway 50 in Colorado is four lane expressway.
U.S. Route 50 (US 50) is a major east–west route in the state of Missouri. It is also known as the Rex M. Whitton Expressway in the capital of Missouri, Jefferson City.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
Mid-Missouri is a loosely-defined region comprising the central area of the U.S. state of Missouri. The region's largest city is Columbia ; the Missouri state capital, Jefferson City, and the University of Missouri are also located here. The region also includes portions of the Lake of the Ozarks, the Ozark Mountains, and the Missouri Rhineland. Mid-Missouri is centered on two contiguous metropolitan areas: the Columbia Metropolitan Area and the Jefferson City Metropolitan Area, which together have a population of over 400,000.
U.S. Highway 65 (US 65) runs north–south through southeastern and north central Arkansas for 309.52 miles (498.12 km). US 65 enters the state from Louisiana south of Eudora, running concurrently with the Great River Road. The route exits into Missouri northwest of Omaha. US 65 runs through the major cities of Pine Bluff and Little Rock.
U.S. Route 60 (US 60) is a part of the United States Numbered Highway System that runs from Brenda, Arizona, east to Virginia Beach, Virginia. In the state of Missouri, US 60 is a main east–west highway that runs through the southern part of the state, from the Oklahoma border to the Illinois border.
US 63 at the Arkansas state line
US 63 at the Iowa state line
