U.S. Route 49 is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 65 is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S. Route 425 in Clayton, Louisiana. The northern terminus is at Interstate 35 just south of Interstate 90 in Albert Lea, Minnesota. Parts of its modern route in Iowa and historic route in Minnesota follow the old Jefferson Highway.
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
U.S. Route 70 or U.S. Highway 70 is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. Established as one of the original highways of 1926, it originally ran only to Holbrook, Arizona, then was extended in 1934 as a coast to coast route, with the current eastern terminus near the Atlantic Ocean in Atlantic, North Carolina, and the former western terminus near the Pacific Ocean in Los Angeles, California. The current western terminus was then truncated to US 60 / SR 77 in Globe, Arizona. Before the completion of the Interstate system, U.S. Highway 70 was sometimes referred to as the "Broadway of America", due to its status as one of the main east–west thoroughfares in the nation. It was also promoted as the "Treasure Trail" by the U.S. Highway 70 Association as of 1951.
Interstate 555 (I-555) is an Interstate Highway that connects Turrell, Arkansas, at I-55 to Jonesboro at Highway 91 (AR 91). Formerly known as U.S. Highway 63 (US 63), the highway was converted in the early 21st century to Interstate Highway standards.
Interstate 530 (I-530) in Arkansas is a spur route of the Interstate highway system, traveling 46.65 miles (75.08 km) from Pine Bluff north-northwest to Little Rock at an interchange of I-30/I-440/U.S. Highway 65 (US 65)/US 67/US 167. The highway also travels through the cities of Redfield and White Hall. In the future, I-530 will be extended to I-69 west of Monticello. A short section near the future I-69 alignment has been signed as Highway 530 (AR 530).
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at US 67 /Arkansas Highway 226 (AR 226) near Cash and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus is at US 64/US 70/US 79 in Memphis, Tennessee.
Highway 463 is a north–south state highway in northeast Arkansas. The route of 20.59 miles (33.14 km) runs from Highway 14 very near I-555 at Payneway north to I-555/US 63B in Jonesboro. The route is a redesignation of former U.S. Route 63, which has since been rerouted onto US 49.
Highway 77 is a north–south state highway in Northeast Arkansas. The route of 66.70 miles (107.34 km) runs from US Highway 70 (US 70) in West Memphis north through small towns and agricultural areas of the Arkansas Delta to the Missouri state line. It is generally a low-traffic road except in West Memphis. Created during the 1926 Arkansas state highway numbering, the route was extended in the 1950s and 1960s, including along a former alignment of US 61. AR 77 does not have any spur or business routes.
U.S. Highway 65 (US 65) runs north–south through southeastern and north central Arkansas for 309.52 miles (498.12 km). US 65 enters the state from Louisiana south of Eudora, running concurrently with the Great River Road. The route exits into Missouri northwest of Omaha. US 65 runs through the major cities of Pine Bluff and Little Rock.
Highway 1 is a north–south state highway in east Arkansas. The route of 159.88 miles (257.30 km) runs from US Route 278 (US 278) in McGehee north to Supplemental Route BB at the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing. The highway contains an overlap of approximately 50 miles (80 km) with U.S. Route 49.
U.S. Route 62 is a U.S. highway running from El Paso, Texas northeast to Niagara Falls, New York. In the U.S. state of Arkansas, the route runs 329.9 miles from the Oklahoma border near Summers east to the Missouri border in St. Francis, serving the northern portion of the state. The route passes through several cities and towns, including Fayetteville, Springdale, Bentonville, Harrison, Mountain Home, Pocahontas, and also Piggott. US 62 runs concurrent with several highways in Arkansas including Interstate 49 and U.S. Route 71 between Fayetteville and Bentonville, U.S. Route 412 through much of the state, U.S. Route 65 in the Harrison area, and with U.S. Route 63 and U.S. Route 67 in northeast Arkansas.
Highway 135 is a north–south state highway in northeast Arkansas. The route of 69.67 miles (112.12 km) runs from Interstate 555 (I-555) near Tyronza north through Paragould to US 62.
Highway 91 is a north–south state highway in the Upper Arkansas Delta. The route of 31.91 miles (51.35 km) begins at US Highway 49 (US 49) and Highway 1 at Jonesboro and runs north to US 412 in Walnut Ridge. The route is maintained by the Arkansas Department of Transportation (ArDOT).
Highway 351 is a designation for two state highways in Northeast Arkansas. One route 0.92 miles (1.48 km) in Jonesboro begins at the Interstate 555/US Highway 63 (I-555/US 63) frontage road and runs north to Highway 18 as Industrial Drive. A second route of 13.87 miles (22.32 km) begins at Airport Road and runs north to Highway 358. Between Jonesboro and the northern terminus, the route is designated as part of the Crowley's Ridge Parkway, a National Scenic Byway, and two Civil War trails under the Arkansas Heritage Trails System. Both routes are maintained by the Arkansas State Highway and Transportation Department (AHTD).
Twelve special routes of U.S. Route 63 currently exist. Arkansas and Missouri each contain five, with two in Iowa. There are also five former routings that have been removed from the system.
Several special routes of U.S. Route 49 exist. In order from south to north they are as follows.
Highway 75 is a north–south state highway in the Arkansas Delta. The route runs from Highway 38/Highway 50 north to AR 14/AR 140/AR 149 in Marked Tree. Created during the initial 1926 Arkansas state highway numbering, Highway 75 has been shortened and extended over roughly the same alignment over its lifetime. The highway has one spur route, Highway 75 Spur in the small town of Parkin. Both highways are maintained by the Arkansas Department of Transportation (ArDOT).
Highway 31 is a north–south state highway in Central Arkansas. The route of 75.34 miles (121.25 km) runs from U.S. Route 79B (US 79B) near Pine Bluff north across US 165, US 70, Interstate 40 (I-40) and US 64/US 67/US 167 before terminating at Highway 5 near Romance.
US 63 / US 167 at Junction City 
