U.S. Route 49 is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
U.S. Route 70 or U.S. Highway 70 is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. Established as one of the original highways of 1926, it originally ran only to Holbrook, Arizona, then was extended in 1934 as a coast to coast route, with the current eastern terminus near the Atlantic Ocean in Atlantic, North Carolina, and the former western terminus near the Pacific Ocean in Los Angeles, California. The current western terminus was then truncated to US 60 / SR 77 in Globe, Arizona. Before the completion of the Interstate system, U.S. Highway 70 was sometimes referred to as the "Broadway of America", due to its status as one of the main east–west thoroughfares in the nation. It was also promoted as the "Treasure Trail" by the U.S. Highway 70 Association as of 1951.
Interstate 555 (I-555) is an Interstate Highway that connects Turrell, Arkansas, at I-55 to Jonesboro at Highway 91 (AR 91). It provides a complete freeway corridor between Jonesboro, Arkansas's fifth-largest city, and Memphis, Tennessee. Formerly known as U.S. Highway 63 (US 63), the highway was converted in the early 2000s to Interstate Highway standards. I-555 was dedicated in March 2016.
Interstate 530 (I-530) in Arkansas is a spur route of the Interstate highway system, traveling 46.65 miles (75.08 km) from Pine Bluff north-northwest to Little Rock at an interchange of I-30/US 65/US 67/US 167/I-440. The highway also travels through the cities of Redfield and White Hall. In the future, I-530 will be extended to I-69 west of Monticello. A short section near the future I-69 alignment has been signed as Highway 530.
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at I-57/US 67 near Cash, and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus was at US 64/US 70/US 79 in Memphis, Tennessee.
Highway 463 is a north–south state highway in northeast Arkansas. The route of 20.59 miles (33.14 km) runs from Highway 14 very near I-555 at Payneway north to I-555/US 63B in Jonesboro. The route is a redesignation of former U.S. Route 63, which has since been rerouted onto US 49.
Highway 77 is a north–south state highway in Northeast Arkansas. The route of 66.70 miles (107.34 km) runs from US Highway 70 (US 70) in West Memphis north through small towns and agricultural areas of the Arkansas Delta to Missouri Route 108 at the Missouri state line. It is generally a low-traffic road except in West Memphis. Created during the 1926 Arkansas state highway numbering, the route was extended in the 1950s and 1960s, including along a former alignment of US 61. AR 77 does not have any spur or business routes.
U.S. Highway 65 (US 65) runs north–south through southeastern and north central Arkansas for 309.52 miles (498.12 km). US 65 enters the state from Louisiana south of Eudora, running concurrently with the Great River Road. The route exits into Missouri northwest of Omaha. US 65 runs through the major cities of Pine Bluff and Little Rock.
Arkansas Highway 1 (AR 1) is a designation for three state highways in east Arkansas. One segment of 30.8 miles (49.6 km) runs from U.S. Route 278 (US 278) in McGehee north to US 165 at Back Gate. A second segment of 34.3 miles (55.2 km) runs from US 165 in DeWitt north to US 49 in Marvell. A third segment of 95.8 miles (154.2 km) runs from US 49 at Walnut Corner north to the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing.
U.S. Highway 412 (US 412) runs east-to-west through northern Arkansas for about 290 miles (470 km). The route begins at the Oklahoma state line near Siloam Springs, and ends at the Missouri state line east of Paragould.
Highway 135 is a north–south state highway in northeast Arkansas. The route of 69.67 miles (112.12 km) runs from Interstate 555 (I-555) near Tyronza north through Paragould to US 62.
Highway 91 is a north–south state highway in the Upper Arkansas Delta. The route of 31.91 miles (51.35 km) begins at US Highway 49 (US 49) and Highway 1 at Jonesboro and runs north to US 412B in Walnut Ridge. The route is maintained by the Arkansas Department of Transportation (ArDOT).
Highway 351 is a designation for two state highways in Northeast Arkansas. One route 0.92 miles (1.48 km) in Jonesboro begins at the Interstate 555/US Highway 63 (I-555/US 63) frontage road and runs north to Highway 18 as Industrial Drive. A second route of 13.87 miles (22.32 km) begins at Airport Road and runs north to Highway 358. Between Jonesboro and the northern terminus, the route is designated as part of the Crowley's Ridge Parkway, a National Scenic Byway, and two Civil War trails under the Arkansas Heritage Trails System. Both routes are maintained by the Arkansas State Highway and Transportation Department (AHTD).
Eight special routes of U.S. Route 412 exist.
Twelve special routes of U.S. Route 63 currently exist. Arkansas and Missouri each contain five, with two in Iowa. There are also five former routings that have been removed from the system.
Several special routes of U.S. Route 49 exist. In order from south to north they are as follows.
Highway 75 is a north–south state highway in the Arkansas Delta. The route runs from Highway 38/Highway 50 north to AR 14/AR 140/AR 149 in Marked Tree. Created during the initial 1926 Arkansas state highway numbering, Highway 75 has been shortened and extended over roughly the same alignment over its lifetime. The highway has one spur route, Highway 75 Spur in the small town of Parkin. Both highways are maintained by the Arkansas Department of Transportation (ArDOT).
U.S. Highway 71 is a U.S. highway that runs from Krotz Springs, LA to the Fort Frances–International Falls International Bridge at the Canadian border. In Arkansas, the highway runs from the Louisiana state line near Doddridge to the Missouri state line near Bella Vista. In Texarkana, the highway runs along State Line Avenue with US 59 and partially runs in Texas. Other areas served by the highway include Fort Smith and Northwest Arkansas.
US 63 / US 167 at Junction City 
