Interstate 72 (I-72) is an Interstate Highway in the midwestern United States. Its western terminus is in Hannibal, Missouri, at an intersection with U.S. Route 61 (US 61); its eastern terminus is at Country Fair Drive in Champaign, Illinois. The route runs through the major cities of Decatur, Illinois, and Springfield, Illinois. In 2006, the Illinois General Assembly dedicated all of I-72 as Purple Heart Memorial Highway. The stretch between Springfield and Decatur is also called Penny Severns Memorial Expressway, and the section between mile 35 and the Mississippi River is known as the Free Frank McWorter Historic Highway.
U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35). Until 1991, the highway extended north on what is now Minnesota State Highway 61 through Duluth to the Canada–U.S. border near Grand Portage, then continued to Thunder Bay, Canada, as Ontario Highway 61. Its southern terminus in New Orleans is at an intersection with U.S. Route 90. The route was an important south–north connection in the days before the interstate highway system.
Route 141, also known as Woods Mill Road in parts of St. Louis County, is a state highway located in the western St. Louis metropolitan area. Its northern terminus is at Route 370 in Bridgeton; its southern terminus is at U.S. Route 61/U.S. Route 67 in Arnold, in Jefferson County. The northern stretches of the highway are often referred to as the Maryland Heights Expressway or Earth City Expressway.
U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa. US 67 crosses the Mississippi River twice along its routing. The first crossing is at West Alton, Missouri, where US 67 uses the Clark Bridge to reach Alton, Illinois. About 240 miles (390 km) to the north, US 67 crosses the river again at the Rock Island Centennial Bridge between Rock Island, Illinois, and Davenport, Iowa. Additionally, the route crosses the Missouri River via the Lewis Bridge a few miles southwest of the Clark Bridge.
The Avenue of the Saints is a 563-mile-long (906 km) highway in the Midwestern United States that connects St. Louis, Missouri, and St. Paul, Minnesota.
U.S. Highway 218 (US 218) is an original United States Highway that was created in 1926. Although technically a spur of US 18, US 218 neither begins nor ends at US 18, but overlaps US 18 for eight miles (13 km) near Charles City, Iowa. US 218 begins at U.S. 136 in downtown Keokuk and ends 319 miles (513 km) away at Interstate 35 (I-35) and US 14 at Owatonna, Minnesota. A large portion of US 218 in Iowa is part of the Avenue of the Saints, which connects St. Louis, Missouri, and Saint Paul, Minnesota.
Interstate 255 (I-255) is a bypass route of I-55 in Greater St. Louis. Along with I-270, it forms a loop around the central portion of the bi-state metro area; a majority of I-255 is located on the Illinois half. It shares its southern terminus with I-270 at the junction with I-55; I-270 and I-255 go to the west and east, respectively. U.S. Route 50 (US 50) joins I-255 at Lemay Ferry Road. It crosses the Mississippi River on the Jefferson Barracks Bridge, enters Illinois, and then turns northeast. There is a junction with I-64, where US 50 breaks off and goes east, and then further north there is a junction with I-55 again, I-70, and US 40, all of which are all cosigned together. The next junction is another one with I-270, which is the northern terminus of I-255. After that, the limited-access freeway continues on as Illinois Route 255 (IL 255). I-255 is 30.82 miles (49.60 km) in length.
Route 364, known locally as the Page Extension, the Page Avenue Freeway, the Page Expressway, or simply the Extension, is a freeway that connects St. Louis County in Maryland Heights with St. Charles County in Lake St. Louis via the Veterans Memorial Bridge over the Missouri River. The highway is a designated auxiliary state route of I-64.
Illinois Route 140 is a 52.05-mile-long (83.77 km) east–west highway with its western terminus at Illinois Route 143 in Alton and its eastern terminus at U.S. Route 40 near Mulberry Grove. It also overlaps IL 111 in Alton and IL 127 in Greenville.
Route 47 is a highway in eastern Missouri. Its northern terminus is at Route 79 near Winfield; its southern terminus is at U.S. Route 67 in Bonne Terre.
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at US 67 /Arkansas Highway 226 (AR 226) near Cash and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus was at US 64/US 70/US 79 in Memphis, Tennessee.
State Highway 10 is a state highway in northeastern Oklahoma. It makes a 233.1 miles (375.1 km) crescent through the northeast corner of the state, running from SH-99 in Osage County to Interstate 40 (I-40) near Gore. It has two lettered spur routes.
State Route 287 (SR 287) is a 13.69-mile-long (22.03 km) east–west state highway in the western portion of the U.S. state of Ohio. The western terminus of SR 287 is at SR 245 nearly 1.75 miles (2.82 km) east of West Liberty. Its eastern terminus is at an interchange with U.S. Route 33 (US 33) about 5.25 miles (8.45 km) northeast of North Lewisburg that dually serves as the southern terminus of SR 739.
State Route 181 (SR 181) is a 4.46-mile long (7.18 km) east–west state highway in the northern portion of the U.S. state of Ohio. The western terminus of SR 181 is at a signalized intersection with SR 61 in downtown Crestline, and its eastern terminus is at a T-intersection with SR 309 approximately one mile (1.6 km) west of Ontario.
State Route 94 (SR 94) is a 65.2-mile-long (104.9 km) state highway in the southeastern part of the U.S. state of Georgia. It exists in two distinct sections, split by the Florida state line, traveling west–east within portions of Lowndes, Echols, Clinch, and Charlton counties. It connects U.S. Route 41 (US 41) in Valdosta with Saint George, via Statenville, Needmore, and Fargo.
Interstate 64 (I-64) passes through the Greater St. Louis area in the US state of Missouri. The entire route is concurrent with U.S. Route 40 (US 40). Because the road was a main thoroughfare in the St. Louis area before the development of the Interstate Highway System, it is not uncommon for locals to refer to the stretch of highway as "Highway 40" rather than "I-64". On December 6, 2009, the portion of the highway running through the city of St. Louis was named the Jack Buck Memorial Highway in honor of the late sportscaster.
State Route 229 is an east-west state highway in the central part of the U.S. state of Ohio. The western terminus of State Route 229 is at a T-intersection with State Route 47 just 0.25 miles (0.40 km) south of the village limits of Waldo. Its eastern terminus is more than 50 miles (80 km) to the east at a T-intersection with U.S. Route 36 about 5.5 miles (8.9 km) west of the village of Nellie.
U.S. Route 67 is the portion of a north-south highway in Missouri that starts at the Arkansas state line south of Neelyville and ends at the Illinois state line northeast of West Alton.
K-239 is a 5.677-mile-long (9.136 km) east–west state highway in the U.S. state of Kansas. K-239's western terminus is at a diamond interchange with U.S. Route 69 (US-69) west of the City of Prescott. The eastern terminus is at the Missouri state line, where it continues as Missouri Route A. K-239 is a two-lane highway for its entire length.
US 54 / US 63 in Jefferson City 
US 67 in West Alton 
