NACA (gene)

Last updated
NACA
Protein NACA PDB 3LKX.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NACA , NACA1, skNAC, HSD48, NAC-alpha, nascent polypeptide-associated complex alpha subunit, nascent polypeptide associated complex subunit alpha
External IDs OMIM: 601234; MGI: 106095; HomoloGene: 136025; GeneCards: NACA; OMA:NACA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001113199
NM_001282976
NM_013608

RefSeq (protein)

NP_001106670
NP_001269905
NP_038636
NP_001269905.1
NP_038636.2

Location (UCSC) Chr 12: 56.71 – 56.73 Mb Chr 10: 127.87 – 127.88 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene. [5] [6] [7]

Function

NACA prevents short recently synthesized (i.e., nascent) ribosome-associated polypeptides from inappropriate interactions with cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-translocated into the endoplasmic reticulum. [6] [8]

The NACA protein is expressed in bone during development and acts as a transcriptional coactivator in conjunction with acidic activators. [7]

Interactions

NACA has been shown to interact with BTF3, FADD, [9] C-jun, [10] and 3 members of taxilin family. [11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196531 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061315 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NACA nascent-polypeptide-associated complex alpha polypeptide".
  6. 1 2 Wiedmann B, Sakai H, Davis TA, Wiedmann M (August 1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature. 370 (6489): 434–40. Bibcode:1994Natur.370..434W. doi:10.1038/370434a0. PMID   8047162. S2CID   4353902.
  7. 1 2 Yotov WV, St-Arnaud R (February 1996). "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome. 7 (2): 163–4. doi:10.1007/BF03035343. PMID   8835540. S2CID   33088429. Archived from the original on 2000-09-16.
  8. Rospert S, Dubaquié Y, Gautschi M (October 2002). "Nascent-polypeptide-associated complex". Cell. Mol. Life Sci. 59 (10): 1632–9. doi:10.1007/PL00012490. PMC   11337418 . PMID   12475173. S2CID   8874233.
  9. Stilo R, Liguoro D, di Jeso B, Leonardi A, Vito P (April 2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. doi:10.1016/S0006-291X(03)00487-X. PMID   12684039.
  10. Moreau A, Yotov WV, Glorieux FH, St-Arnaud R (March 1998). "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription". Mol. Cell. Biol. 18 (3): 1312–21. doi:10.1128/MCB.18.3.1312. PMC   108844 . PMID   9488446.
  11. Yoshida K, Nogami S, Satoh S, Tanaka-Nakadate S, Hiraishi H, Terano A, Shirataki H (May 2005). "Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes". Genes Cells. 10 (5): 465–76. doi: 10.1111/j.1365-2443.2005.00848.x . PMID   15836775. S2CID   19426810.

Further reading