NDRG4

NDRG4
Identifiers
Aliases	NDRG4 , BDM1, SMAP-8, SMAP8, NDRG family member 4
External IDs	OMIM: 614463; MGI: 2384590; HomoloGene: 23228; GeneCards: NDRG4; OMA:NDRG4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q21 Start 58,462,846 bp [1] End 58,513,628 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 D1 Start 95,676,980 bp [2] End 95,715,119 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum pons lateral nuclear group of thalamus right frontal lobe prefrontal cortex apex of heart nucleus accumbens cerebellar vermis caudate nucleus dorsolateral prefrontal cortex Top expressed in olfactory tubercle medial dorsal nucleus medial geniculate nucleus pontine nuclei dorsal tegmental nucleus habenula medial vestibular nucleus lateral geniculate nucleus nucleus accumbens globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cytosol basolateral plasma membrane cell projection membrane cytoplasm mitochondrion endoplasmic reticulum membrane Biological process visual learning negative regulation of platelet-derived growth factor receptor signaling pathway cell migration involved in heart development cell differentiation negative regulation of smooth muscle cell proliferation regulation of endocytic recycling negative regulation of smooth muscle cell migration cardiac muscle cell proliferation embryonic heart tube development heart looping cell growth vesicle docking positive regulation of ERK1 and ERK2 cascade positive regulation of neuron projection development brain development signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65009 234593 Ensembl ENSG00000103034 ENSMUSG00000036564 UniProt Q9ULP0 Q8BTG7 RefSeq (mRNA) NM_001130487 NM_001242833 NM_001242834 NM_001242835 NM_001242836 NM_020465 NM_022910 NM_001363869 NM_001195006 NM_145602 RefSeq (protein) NP_001123959 NP_001229762 NP_001229763 NP_001229764 NP_001229765 NP_065198 NP_075061 NP_001350798 NP_001365261 NP_001365262 NP_001365263 NP_001365264 NP_001365265 NP_001365266 NP_001365267 NP_001365268 NP_001365269 NP_001365270 NP_001365271 NP_001365272 NP_001365273 NP_001365274 NP_001365275 NP_001365276 NP_001181935 NP_663577 NP_001359350 NP_001359352 NP_001359354 NP_001359355 NP_001359356 NP_001359357 NP_001359358 NP_001359359 NP_001359360 NP_001359361 NP_001359362 NP_001359363 NP_001359364 Location (UCSC) Chr 16: 58.46 – 58.51 Mb Chr 8: 95.68 – 95.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene. ^{[5] [6] [7]}

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103034 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036564 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID   11352569.
6. Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". J Cell Biochem. 98 (1): 185–93. doi:10.1002/jcb.20763. PMID   16408304. S2CID   10192022.
7. "Entrez Gene: NDRG4 NDRG family member 4".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID   10574461.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44. doi:10.1023/A:1017934810825. PMID   11936845. S2CID   24226208.
• Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63. doi:10.1016/S0165-3806(02)00300-0. PMID   11978393.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nishimoto S, Tawara J, Toyoda H, et al. (2003). "A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells". Eur. J. Biochem. 270 (11): 2521–31. doi: 10.1046/j.1432-1033.2003.03626.x . PMID   12755708.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.