NFKBIE

NFKBIE
Identifiers
Aliases	NFKBIE , IKBE, NFKB inhibitor epsilon
External IDs	OMIM: 604548 MGI: 1194908 HomoloGene: 36160 GeneCards: NFKBIE
Gene location (Human)
Chr.	Chromosome 6 (human)
End	44,265,788 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	45,874,095 bp
RNA expression pattern
	Top expressed in
	spleen; ; monocyte; ; appendix; ; bone marrow cells; ; lymph node; ; blood; ; islet of Langerhans; ; thymus; ; prefrontal cortex; ; gallbladder;
	Top expressed in
	spleen; ; thymus; ; subcutaneous adipose tissue; ; blood; ; saccule; ; condyle; ; internal carotid artery; ; fossa; ; otic placode; ; female urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; perinuclear region of cytoplasm ; Golgi apparatus ; fibrillar center ; nucleus ; cytosol ;
Biological process	cytoplasmic sequestering of transcription factor ; D-serine transport ;
	Sources:Amigo / QuickGO
Orthologs
	4794
	18037
	ENSG00000146232
	ENSMUSG00000023947
	O00221
	O54910
	NM_004556
	NM_008690 ; NM_001304956
	NP_004547
	NP_001291885 ; NP_032716
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.^[5]^[6]

Function

NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.^[6]

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).^[5]

Interactions

NFKBIE has been shown to interact with NFKB2,^[7] RELA,^[7] NFKB1 ^[7] and REL.^[7]^[8]^[9]

Related Research Articles

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunithhv xlh thfbeta is a protein that in humans is encoded by the IKBKB gene.

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.

The IκB kinase is an enzyme complex that is involved in propagating the cellular response to inflammation.

<span class="mw-page-title-main">IκBα</span> Protein-coding gene in the species Homo sapiens

IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene.

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.

Transcription factor RelB is a protein that in humans is encoded by the RELB gene.

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.

Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.

TBK1 is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene in humans. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis.

Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I-kappa-B kinase epsilon or IKK-epsilon is an enzyme that in humans is encoded by the IKBKE gene.

Nuclear factor of activated T-cells 5, also known as NFAT5 and sometimes TonEBP, is a human gene that encodes a transcription factor that regulates the expression of genes involved in the osmotic stress.

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene. TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.

Pirin is a protein that in humans is encoded by the PIR gene.

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta also known as IκBNS is a protein in humans that is encoded by the NFKBID gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146232 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023947 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon".
1 2 Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738 . PMID 9135156.
1 2 3 4 Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. United States. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. ISSN 0270-7306. PMC 232469 . PMID 9315679.
↑ Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. United States. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi: 10.1073/pnas.90.19.8962 . ISSN 0027-8424. PMC 47481 . PMID 8415639.
↑ Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. United States. 164 (6): 3316–22. doi: 10.4049/jimmunol.164.6.3316 . ISSN 0022-1767. PMID 10706725.

Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription". Mol. Cell. Biol. 14 (4): 2593–603. doi:10.1128/mcb.14.4.2593. PMC 358627 . PMID 8139561.
Kumar S, Gélinas C (1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi: 10.1073/pnas.90.19.8962 . PMC 47481 . PMID 8415639.
Whiteside ST, Epinat JC, Rice NR, Israël A (1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738 . PMID 9135156.
Curristin SM, Bird KJ, Tubbs RJ, Ruddell A (1997). "VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells". J. Virol. 71 (8): 5972–81. doi:10.1128/JVI.71.8.5972-5981.1997. PMC 191853 . PMID 9223487.
Li Z, Nabel GJ (1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. PMC 232469 . PMID 9315679.
Spiecker M, Darius H, Liao JK (2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. 164 (6): 3316–22. doi: 10.4049/jimmunol.164.6.3316 . PMID 10706725.
Bourke E, Kennedy EJ, Moynagh PN (2001). "Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells" (PDF). J. Biol. Chem. 275 (51): 39996–40002. doi: 10.1074/jbc.M007693200 . PMID 10998424. S2CID 56360025.
Lee SH, Hannink M (2002). "Characterization of the nuclear import and export functions of Ikappa B(epsilon)". J. Biol. Chem. 277 (26): 23358–66. doi: 10.1074/jbc.M111559200 . PMID 11970947.
Bruno ME, Borchers CH, Dial JM, et al. (2002). "Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics". Arch. Biochem. Biophys. 406 (2): 153–64. doi:10.1016/S0003-9861(02)00452-6. PMID 12361703.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Emmerich F, Theurich S, Hummel M, et al. (2004). "Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells". J. Pathol. 201 (3): 413–20. doi:10.1002/path.1454. PMID 14595753. S2CID 33577004.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Nasu-Nishimura Y, Hayashi T, Ohishi T, et al. (2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes Cells. 11 (6): 607–14. doi: 10.1111/j.1365-2443.2006.00966.x . PMID 16716191. S2CID 7935936.
Stefansson B, Brautigan DL (2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". J. Biol. Chem. 281 (32): 22624–34. doi: 10.1074/jbc.M601772200 . PMID 16769727.
Chapman SJ, Khor CC, Vannberg FO, et al. (2007). "IkappaB genetic polymorphisms and invasive pneumococcal disease". Am. J. Respir. Crit. Care Med. 176 (2): 181–7. doi:10.1164/rccm.200702-169OC. PMID 17463416.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146232 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023947 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon".

[pmid9135156-6] 1 2 Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738 . PMID 9135156.

[pmid9315679-7] 1 2 3 4 Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. United States. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. ISSN 0270-7306. PMC 232469 . PMID 9315679.

[pmid8415639-8] Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. United States. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi: 10.1073/pnas.90.19.8962 . ISSN 0027-8424. PMC 47481 . PMID 8415639.

[pmid10706725-9] Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. United States. 164 (6): 3316–22. doi: 10.4049/jimmunol.164.6.3316 . ISSN 0022-1767. PMID 10706725.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

NFKBIE

Contents

Function

Interactions

Related Research Articles

References

Further reading