NUDCD3

NUDCD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGV
Identifiers
Aliases	NUDCD3 , NudCL, NudC domain containing 3
External IDs	OMIM: 610296; MGI: 2144158; HomoloGene: 9097; GeneCards: NUDCD3; OMA:NUDCD3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,490,658 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,150,415 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; cerebellar hemisphere; ; gastrocnemius muscle; ; stromal cell of endometrium; ; nucleus accumbens; ; islet of Langerhans; ; sural nerve; ; popliteal artery; ; putamen;
	Top expressed in
	superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; cerebellar cortex; ; piriform cortex; ; temporal muscle; ; subiculum; ; triceps brachii muscle; ; cerebellar vermis; ; habenula; ; olfactory tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; unfolded protein binding ;
Cellular component	cytoplasm ; cytoplasmic dynein complex ;
Biological process	protein folding ; cilium assembly ; protein localization to pericentriolar material ; developmental process ;
	Sources:Amigo / QuickGO
Orthologs
	23386
	209586
	ENSG00000015676
	ENSMUSG00000053838
	Q8IVD9
	Q8R1N4
	NM_015332
	NM_173748 ; NM_001363446
	NP_056147
	NP_776109 ; NP_001350375
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 30, 2024

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.^[5]

Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.^[5]

Related Research Articles

Probable G-protein coupled receptor 22 is a protein that in humans is encoded by the GPR22 gene.

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene.

Nuclear distribution protein nudE homolog 1 is a protein that in humans is encoded by the NDE1 gene.

Synaptophysin-like protein 1 is a protein that in humans is encoded by the SYPL1 gene.

Shugoshin 2(Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.

RING finger protein 32 is a protein that in humans is encoded by the RNF32 gene.

RNA-binding protein 33 is a protein that in humans is encoded by the RBM33 gene.

28 kDa heat- and acid-stable phosphoprotein is a protein that in humans is encoded by the PDAP1 gene.

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.

Cytoplasmic dynein 1 light intermediate chain 2 is a protein that in humans is encoded by the DYNC1LI2 gene.

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.

Putative methyltransferase NSUN5 is an enzyme that in humans is encoded by the NSUN5 gene.

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.

28S ribosomal protein S33, mitochondrial is a protein that in humans is encoded by the MRPS33 gene.

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 is a protein that in humans is encoded by the BAIAP2L1 gene.

Kelch-like protein 7 is a protein that in humans is encoded by the KLHL7 gene.

Poly [ADP-ribose] polymerase 12 is an enzyme that in humans is encoded by the PARP12 gene.

Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene.

NudC domain-containing protein 2 is a protein that in humans is encoded by the NUDCD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000015676 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053838 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: NUDCD3 NudC domain containing 3".

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID 10470851.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi: 10.1126/science.1058040 . PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhou T, Zimmerman W, Liu X, Erikson RL (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9039–44. Bibcode:2006PNAS..103.9039Z. doi: 10.1073/pnas.0602916103 . PMC 1482562 . PMID 16754861.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000015676 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: NUDCD3 NudC domain containing 3".

[1]

[2]

[3]

[4]

[5]

NUDCD3

Contents

Function

Related Research Articles

References

Further reading