NWD1

Last updated
NWD1
Identifiers
Aliases NWD1 , NACHT and WD repeat domain containing 1
External IDs OMIM: 616250; MGI: 2442268; HomoloGene: 72261; GeneCards: NWD1; OMA:NWD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007525
NM_001290355
NM_001347994

NM_001159403
NM_176940

RefSeq (protein)

NP_001007526
NP_001277284
NP_001334923

NP_795914

Location (UCSC) Chr 19: 16.72 – 16.82 Mb Chr 8: 72.65 – 72.72 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species. [5] The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188039 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048148 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11): R251. doi: 10.1186/gb-2007-8-11-r251 . PMC   2258186 . PMID   18039395.
  6. Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC (2014). "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling". Oncotarget. 5 (6): 1657–1665. doi:10.18632/oncotarget.1850. PMC   4039239 . PMID   24681825.

Further reading