NWD1

NWD1
Identifiers
Aliases	NWD1 , NACHT and WD repeat domain containing 1
External IDs	OMIM: 616250; MGI: 2442268; HomoloGene: 72261; GeneCards: NWD1; OMA:NWD1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 16,719,847 bp [1] End 16,817,963 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B3.3 Start 72,646,711 bp [2] End 72,717,876 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa right uterine tube corpus callosum caudate nucleus nucleus accumbens temporal lobe amygdala putamen anterior cingulate cortex right frontal lobe Top expressed in olfactory epithelium Epithelium of choroid plexus lumbar subsegment of spinal cord substantia nigra dentate gyrus of hippocampal formation granule cell Rostral migratory stream primary visual cortex superior frontal gyrus cerebellar cortex hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding nucleotide binding RNA binding Cellular component cytoplasm cytosol U5 snRNP precatalytic spliceosome catalytic step 2 spliceosome Biological process RNA splicing positive regulation of gene expression negative regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284434 319555 Ensembl ENSG00000188039 ENSMUSG00000048148 UniProt Q149M9 A6H603 RefSeq (mRNA) NM_001007525 NM_001290355 NM_001347994 NM_001159403 NM_176940 RefSeq (protein) NP_001007526 NP_001277284 NP_001334923 NP_795914 Location (UCSC) Chr 19: 16.72 – 16.82 Mb Chr 8: 72.65 – 72.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species. ^[5] The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000188039 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048148 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11) R251. doi: 10.1186/gb-2007-8-11-r251 . PMC   2258186 . PMID   18039395.
6. Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC (2014). "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling". Oncotarget. 5 (6): 1657–1665. doi:10.18632/oncotarget.1850. PMC   4039239 . PMID   24681825.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Correa RG, Ware CF, Reed JC (2014). "NLRs: Sentinels of innate immunity or cancer culprits?". Oncoscience. 1 (5): 308–9. doi:10.18632/oncoscience.44. PMC   4278305 . PMID   25594025.