Nenad Ban

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Nenad Ban
Nenad Ban (Scientist).jpg
Born (1966-05-03) May 3, 1966 (age 57)
Zagreb, Croatia
NationalityCroatian
Alma mater University of Zagreb, Croatia, University of California at Riverside
Known for Structural biology, structure and function of the ribosome, structure and function of multi-enzymes
Spouse Eilika Weber-Ban
Awards Newcomb Cleveland Prize (2001)
Rössler Prize (2009)
Heinrich Wieland Prize (2010)
Ernst Jung Prize (2017)
Otto Naegeli Prize (2018)
Scientific career
Fields Biochemistry and Biophysics
Institutions ETH Zurich
Doctoral advisor Alexander McPherson
Other academic advisors Thomas A. Steitz

Nenad Ban is a biochemist born in Zagreb, Croatia who currently works at the ETH Zurich, Swiss Federal Institute of Technology, as a professor of Structural Molecular Biology. He is a pioneer in studying gene expression mechanisms and the participating protein synthesis machinery.

Contents

Career

Nenad Ban was born in 1966 in Zagreb. His parents, Jasna and Zvonimir, were scientists and university professors. [1] He received a degree in molecular biology at the Faculty of Science, University of Zagreb and decided to continue with his studies in the United States where he obtained a PhD degree at the University of California, Riverside in the laboratory of Alexander McPherson. He carried out his postdoctoral studies at Yale University in the laboratory of Thomas A. Steitz.

Already in high school he developed an interest in understanding the mechanisms of protein synthesis, which led him to the laboratory of Prof. Zeljko Kucan and Ivana Weygand in Zagreb where he investigated tRNA synthetases, enzymes that charge tRNAs with amino acids to prepare them as substrates for protein synthesis on the ribosome. These interests brought him to the Department of Molecular Biophysics and Biochemistry at Yale University where he determined the atomic structure of the large ribosomal subunit by X-ray crystallography, as part of the group in the laboratory of Thomas A. Steitz. These results demonstrated that the ribosome is a ribozyme. [2]

Since 2000 Nenad Ban is a professor of structural molecular biology at the ETH Zurich. [3] (Swiss Federal Institute of Technology). His group is investigating protein synthesis both in terms of the chemistry of the process and with respect to how it is regulated, how proteins co-translationally fold, [4] [5] how they are co-translationally modified, [6] and how they are targeted to membranes [7] and sorted to different cellular compartments. [8] [9] [10] [11]

Nenad Ban’s group at ETH Zurich revealed the mechanisms behind the key steps in eukaryotic cytoplasmic and mitochondrial translation with a broad impact on a wide range of fields in biology, chemistry and biomedicine. [12] [13]

His group also contributed to our understanding of giant multifunctional enzymes involved in fatty acid synthesis offering mechanistic insights into substrate shuttling and delivery in such megasynthases. [14] [15] [16] [17] [18]

Honors

Nenad Ban is a member of the National Academy of Sciences, the European Molecular Biology Organization (EMBO), the German Academy of Sciences, the Croatian Academy of Arts and Sciences and the recipient of several prizes and awards including the Heinrich Wieland Prize, [19] Rössler Prize of the ETH Zurich, [20] the Latsis prize, [21] the Friedrich Miescher Prize of the Swiss Society for Biochemistry, [22] Spiridon Brusina medal, the AAAS Newcomb Cleveland Prize. [23] and the Jung Prize. [24]

Personal life

Ban is married to Eilika Weber, a German scientist whom he met in the United States during his doctoral study. They have two sons, Arvid and Ivo. [1]

Related Research Articles

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Ribosomes are macromolecular machines, found within all cells, that perform biological protein synthesis. Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins. The ribosomes and associated molecules are also known as the translational apparatus.

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<span class="mw-page-title-main">Venki Ramakrishnan</span> Indian-born British-American structural biologist (born 1952)

Venkatraman "Venki" Ramakrishnan is an Indian-born British and American structural biologist. He shared the 2009 Nobel Prize in Chemistry with Thomas A. Steitz and Ada Yonath for research on the structure and function of ribosomes.

<span class="mw-page-title-main">Lumazine synthase</span> Class of enzymes

Lumazine synthase (EC 2.5.1.78, 6,7-dimethyl-8-ribityllumazine synthase, 6,7-dimethyl-8-ribityllumazine synthase 2, 6,7-dimethyl-8-ribityllumazine synthase 1, lumazine synthase 2, lumazine synthase 1, type I lumazine synthase, type II lumazine synthase, RIB4, MJ0303, RibH, Pbls, MbtLS, RibH1 protein, RibH2 protein, RibH1, RibH2) is an enzyme with systematic name 5-amino-6-(D-ribitylamino)uracil butanedionetransferase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Leukotriene A4</span> Chemical compound

Leukotriene A4(LTA4) is a leukotriene, and is the precursor for the productions of LTB4 (leukotriene B)) and LTC4 (leukotriene C4).

<span class="mw-page-title-main">5S ribosomal RNA</span> RNA component of the large subunit of the ribosome

The 5S ribosomal RNA is an approximately 120 nucleotide-long ribosomal RNA molecule with a mass of 40 kDa. It is a structural and functional component of the large subunit of the ribosome in all domains of life, with the exception of mitochondrial ribosomes of fungi and animals. The designation 5S refers to the molecule's sedimentation velocity in an ultracentrifuge, which is measured in Svedberg units (S).

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<span class="mw-page-title-main">Prokaryotic large ribosomal subunit</span>

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Ribosomal particles are denoted according to their sedimentation coefficients in Svedberg units. The 60S subunit is the large subunit of eukaryotic 80S ribosomes. It is structurally and functionally related to the 50S subunit of 70S prokaryotic ribosomes. However, the 60S subunit is much larger than the prokaryotic 50S subunit and contains many additional protein segments, as well as ribosomal RNA expansion segments.

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<span class="mw-page-title-main">Eukaryotic ribosome</span> Large and complex molecular machine

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References

  1. 1 2 Rudež, Tanja (26 February 2016). "Genijalnom Hrvatu za dlaku izmakla nobelova nagrada: Upoznajte čovjeka koji je riješio jedan od najvećih misterija molekularne biologije". Jutarnji list (in Croatian). Retrieved 26 February 2016.
  2. ↑ Ban, Nenad; Nissen, Poul; Hansen, Jeffrey; Moore, Peter B.; Steitz, Thomas A. (11 August 2000). "The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution". Science. American Association for the Advancement of Science (AAAS). 289 (5481): 905–920. Bibcode:2000Sci...289..905B. doi:10.1126/science.289.5481.905. ISSN   0036-8075. PMID   10937989.
  3. ↑ "ETH Zurich: Prof. Nenad Ban". Mol.biol.ethz.ch. 2013-02-05. Archived from the original on 2013-09-10. Retrieved 2013-09-09.
  4. ↑ Ferbitz, Lars; Maier, Timm; Patzelt, Holger; Bukau, Bernd; Deuerling, Elke; Ban, Nenad (29 August 2004). "Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins". Nature. Springer Science and Business Media LLC. 431 (7008): 590–596. Bibcode:2004Natur.431..590F. doi:10.1038/nature02899. ISSN   0028-0836. PMID   15334087. S2CID   4427021.
  5. ↑ Kramer, Günter; Rauch, Thomas; Rist, Wolfgang; Vorderwülbecke, Sonja; Patzelt, Holger; Schulze-Specking, Agnes; Ban, Nenad; Deuerling, Elke; Bukau, Bernd (2002). "L23 protein functions as a chaperone docking site on the ribosome". Nature. Springer Science and Business Media LLC. 419 (6903): 171–174. Bibcode:2002Natur.419..171K. doi:10.1038/nature01047. ISSN   0028-0836. PMID   12226666. S2CID   2365591.
  6. ↑ Bingel-Erlenmeyer, Rouven; Kohler, Rebecca; Kramer, Günter; Sandikci, Arzu; Antolić, Snježana; Maier, Timm; Schaffitzel, Christiane; Wiedmann, Brigitte; Bukau, Bernd; Ban, Nenad (20 February 2008). "A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing". Nature. Springer Science and Business Media LLC. 452 (7183): 108–111. Bibcode:2008Natur.452..108B. doi:10.1038/nature06683. ISSN   0028-0836. PMID   18288106. S2CID   4411842.
  7. ↑ Ataide, Sandro F.; Schmitz, Nikolaus; Shen, Kuang; Ke, Ailong; Shan, Shu-ou; Doudna, Jennifer A.; Ban, Nenad (18 February 2011). "The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor". Science. American Association for the Advancement of Science (AAAS). 331 (6019): 881–886. Bibcode:2011Sci...331..881A. doi:10.1126/science.1196473. ISSN   0036-8075. PMC   3758919 . PMID   21330537.
  8. ↑ Estrozi, Leandro F; Boehringer, Daniel; Shan, Shu-ou; Ban, Nenad; Schaffitzel, Christiane (12 December 2010). "Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor". Nature Structural & Molecular Biology. Springer Science and Business Media LLC. 18 (1): 88–90. doi:10.1038/nsmb.1952. ISSN   1545-9993. PMC   3764645 . PMID   21151118.
  9. ↑ Schaffitzel, Christiane; Oswald, Miro; Berger, Imre; Ishikawa, Takashi; Abrahams, Jan Pieter; Koerten, Henk K.; Koning, Roman I.; Ban, Nenad (29 October 2006). "Structure of the E. coli signal recognition particle bound to a translating ribosome". Nature. Springer Science and Business Media LLC. 444 (7118): 503–506. Bibcode:2006Natur.444..503S. doi:10.1038/nature05182. hdl: 1887/3620885 . ISSN   0028-0836. PMID   17086205. S2CID   4400092.
  10. ↑ Kobayashi, Kan; Jomaa, Ahmad; Lee, Jae Ho; Chandrasekar, Sowmya; Boehringer, Daniel; Shan, Shu-ou; Ban, Nenad (2018-04-20). "Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex". Science. 360 (6386): 323–327. doi:10.1126/science.aar7924. ISSN   0036-8075. PMC   6309883 . PMID   29567807.
  11. ↑ Jomaa, Ahmad; Gamerdinger, Martin; Hsieh, Hao-Hsuan; Wallisch, Annalena; Chandrasekaran, Viswanathan; Ulusoy, Zeynel; Scaiola, Alain; Hegde, Ramanujan S.; Shan, Shu-ou; Ban, Nenad; Deuerling, Elke (2022-02-25). "Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting". Science. 375 (6583): 839–844. doi:10.1126/science.abl6459. ISSN   0036-8075. PMC   7612438 . PMID   35201867.
  12. ↑ Klinge, Sebastian; Voigts-Hoffmann, Felix; Leibundgut, Marc; Arpagaus, Sofia; Ban, Nenad (18 November 2011). "Crystal Structure of the Eukaryotic 60 S Ribosomal Subunit in Complex with Initiation Factor 6". Science. American Association for the Advancement of Science (AAAS). 334 (6058): 941–948. Bibcode:2011Sci...334..941K. doi:10.1126/science.1211204. ISSN   0036-8075. PMID   22052974. S2CID   206536444.
  13. ↑ Rabl, Julius; Leibundgut, Marc; Ataide, Sandro F.; Haag, Andrea; Ban, Nenad (11 February 2011). "Crystal Structure of the Eukaryotic 40 S Ribosomal Subunit in Complex with Initiation Factor 1". Science. American Association for the Advancement of Science (AAAS). 331 (6018): 730–736. Bibcode:2011Sci...331..730R. doi:10.1126/science.1198308. hdl: 20.500.11850/153130 . ISSN   0036-8075. PMID   21205638. S2CID   24771575.
  14. ↑ Maier, Timm; Leibundgut, Marc; Ban, Nenad (5 September 2008). "The Crystal Structure of a Mammalian Fatty Acid Synthase". Science. American Association for the Advancement of Science (AAAS). 321 (5894): 1315–1322. Bibcode:2008Sci...321.1315M. doi:10.1126/science.1161269. ISSN   0036-8075. PMID   18772430. S2CID   3168991.
  15. ↑ Leibundgut, Marc; Jenni, Simon; Frick, Christian; Ban, Nenad (13 April 2007). "Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase". Science. American Association for the Advancement of Science (AAAS). 316 (5822): 288–290. Bibcode:2007Sci...316..288L. doi:10.1126/science.1138249. ISSN   0036-8075. PMID   17431182. S2CID   32176226.
  16. ↑ Jenni, Simon; Leibundgut, Marc; Boehringer, Daniel; Frick, Christian; Mikolásek, Bohdan; Ban, Nenad (13 April 2007). "Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling". Science. American Association for the Advancement of Science (AAAS). 316 (5822): 254–261. Bibcode:2007Sci...316..254J. doi:10.1126/science.1138248. ISSN   0036-8075. PMID   17431175. S2CID   12820568.
  17. ↑ Maier, Timm; Jenni, Simon; Ban, Nenad (3 March 2006). "Architecture of Mammalian Fatty Acid Synthase at 4.5 Å Resolution". Science. American Association for the Advancement of Science (AAAS). 311 (5765): 1258–1262. Bibcode:2006Sci...311.1258M. doi:10.1126/science.1123248. ISSN   0036-8075. PMID   16513975. S2CID   39658597.
  18. ↑ Jenni, Simon; Leibundgut, Marc; Maier, Timm; Ban, Nenad (3 March 2006). "Architecture of a Fungal Fatty Acid Synthase at 5 Å Resolution". Science. American Association for the Advancement of Science (AAAS). 311 (5765): 1263–1267. Bibcode:2006Sci...311.1263J. doi:10.1126/science.1123251. ISSN   0036-8075. PMID   16513976. S2CID   2191407.
  19. ↑ "Heinrich Wieland Prize". Heinrich-wieland-preis.de. 2010-10-28. Archived from the original on 2013-06-30. Retrieved 2013-09-09.
  20. ↑ "ETH Zürich – Archiv 2009". Ethz.ch. Retrieved 2013-09-09.
  21. ↑ "Preistragende des Latsis-Preises". ETH Zürich (in German). 30 November 2020. Retrieved 27 November 2021.
  22. ↑ scnat.ch. "Awardees". Swissbiochem.ch. Archived from the original on 2013-10-29. Retrieved 2013-09-09.
  23. ↑ "Newcomb Cleveland Prize – Recipients". AAAS. Archived from the original on 2012-10-23. Retrieved 2013-09-09.
  24. ↑ "Professor Tobias Moser and Professor Nenad Ban". jung-stiftung.de. Retrieved 2017-01-09.
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