Neridronic acid

Neridronic acid

Clinical data
ATC code	none
Identifiers
IUPAC name (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
CAS Number	79778-41-9  Y
PubChem CID	71237
ChemSpider	64372  N
UNII	8U27U3RIN4
CompTox Dashboard (EPA)	DTXSID40868545
ECHA InfoCard	100.163.818
Chemical and physical data
Formula	C6H17NO7P2
Molar mass	277.150 g·mol−1
3D model (JSmol)	Interactive image
SMILES C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN
InChI InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14) N Key:PUUSSSIBPPTKTP-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

Neridronic acid (INN; the anion is called neridronate) is a bisphosphonate. In Italy it is used to treat osteogenesis imperfecta and Paget's disease of bone. ^[1]

A 2013 clinical trial suggests complex regional pain syndrome type 1 (CRPS) responds to treatment with intravenous neridronate. ^[2]

References

1. Gatti D, Viapiana O, Idolazzi L, Fracassi E, Adami S (2009). "Neridronic acid for the treatment of bone metabolic diseases". Expert Opin Drug Metab Toxicol. 5 (10): 1305–11. doi:10.1517/17425250903029190. PMID   19761412. S2CID   22274296.
2. Varenna M, Adami S, Rossini M, et al. (March 2013). "Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study". Rheumatology. 52 (3): 534–42. doi: 10.1093/rheumatology/kes312 . PMID   23204550.