Minodronic acid

Minodronic acid
Names
	Preferred IUPAC name [1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
	Other names Minodronate; YM 529
Identifiers
CAS Number	180064-38-4 ; 155648-60-5 (monohydrate) ;
3D model (JSmol)	Interactive image ;
ChEMBL	ChEMBL319144 ;
ChemSpider	115805 ;
IUPHAR/BPS	3164 ;
PubChem CID	130956 ;
UNII	40SGR63TGL ; 457X74V7ND (monohydrate) ;
CompTox Dashboard (EPA)	DTXSID4048779 ;
	InChI InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18) Key: VMMKGHQPQIEGSQ-UHFFFAOYSA-N ;
	SMILES O=P(O)(O)C(O)(P(=O)(O)O)Cc1cnc2ccccn12;
Properties
Chemical formula	C9H12N2O7P2
Molar mass	322.150 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated January 01, 2026

Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis.^[1] Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity.^[2]

References

↑ Shridhar Hegde and Michelle Schmidt (2009). "To Market, To Market - 2009. 16. Minodronic acid". Annual Reports in Medicinal Chemistry. 45: 509–510. doi:10.1016/s0065-7743(10)45028-9.
↑ Sorbera, L.A.; Castañer, J.; Leeson, P.A. (2002). "Minodronic Acid". Drugs of the Future. 27 (10): 935–941. doi:10.1358/dof.2002.027.10.701186.

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[1] Shridhar Hegde and Michelle Schmidt (2009). "To Market, To Market - 2009. 16. Minodronic acid". Annual Reports in Medicinal Chemistry. 45: 509–510. doi:10.1016/s0065-7743(10)45028-9.

[2] Sorbera, L.A.; Castañer, J.; Leeson, P.A. (2002). "Minodronic Acid". Drugs of the Future. 27 (10): 935–941. doi:10.1358/dof.2002.027.10.701186.

[1]

[2]

v t e Drugs for treatment of bone diseases (M05)
Bisphosphonates	Nitrogenous Alendronic acid Ibandronic acid Incadronic acid Minodronic acid Neridronic acid Pamidronic acid Risedronic acid Zoledronic acid Non-nitrogenous Etidronic acid Clodronic acid Tiludronic acid
Bone morphogenetic proteins	Dibotermin alfa Eptotermin alfa
Other	Resorption inhibitor Ipriflavone Aluminium chlorohydrate Dual action bone agent Strontium ranelate RANKL inhibitor Denosumab Sclerostin inhibitor Romosozumab Cathepsin K inhibitor Odanacatib Parathyroid hormone-related protein analogues Abaloparatide Teriparatide Calcitonin Calcium Vitamin D

Names

Preferred IUPAC name [1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
Other names Minodronate; YM 529
Identifiers
CAS Number	180064-38-4 ^Y 155648-60-5 (monohydrate)^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL319144 ^Y
ChemSpider	115805 ^Y
IUPHAR/BPS	3164
PubChem CID	130956
UNII	40SGR63TGL ^Y 457X74V7ND (monohydrate)^Y
CompTox Dashboard (EPA)	DTXSID4048779
InChI InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)^Y Key: VMMKGHQPQIEGSQ-UHFFFAOYSA-N^Y
SMILES O=P(O)(O)C(O)(P(=O)(O)O)Cc1cnc2ccccn12
Properties
Chemical formula	C₉H₁₂N₂O₇P₂
Molar mass	322.150 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references