Neural adaptation

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Neural adaptation or sensory adaptation is a gradual decrease over time in the responsiveness of the sensory system to a constant stimulus. It is usually experienced as a change in the stimulus. For example, if a hand is rested on a table, the table's surface is immediately felt against the skin. Subsequently, however, the sensation of the table surface against the skin gradually diminishes until it is virtually unnoticeable. The sensory neurons that initially respond are no longer stimulated to respond; this is an example of neural adaptation.

Contents

All sensory and neural systems have a form of adaptation to constantly detect changes in the environment. Neural receptor cells that process and receive stimulation go through constant changes for mammals and other living organisms to sense vital changes in their environment. Some key players in several neural systems include Ca2+ions (see Calcium in biology) that send negative feedback in second messenger pathways that allow the neural receptor cells to close or open channels in response to the changes of ion flow. [1] There are also mechanoreception systems that use calcium inflow to physically affect certain proteins and move them to close or open channels.

Functionally, it is highly possible that adaptation may enhance the limited response range of neurons to encode sensory signals with much larger dynamic ranges by shifting the range of stimulus amplitudes. [2] Also, in neural adaptation there is a sense of returning to baseline from a stimulated response. [3] Recent work suggests that these baseline states are actually determined by long-term adaptation to the environment. [3] Varying rates or speed of adaptation is an important indicator for tracking different rates of change in the environment or the organism itself. [3]

Current research shows that although adaptation occurs at multiple stages of each sensory pathway, it is often stronger and more stimulus specific at "cortical" level rather than "subcortical stages". [2] In short, neural adaptation is thought to happen at a more central level at the cortex. [4]

Fast and slow adaptation

There is fast adaptation and slow adaptation. Fast adaptation occurs immediately after a stimulus is presented i.e., within hundreds of milliseconds. Slow adaptive processes can take minutes, hours or even days. The two classes of neural adaptation may rely on very different physiological mechanisms. [2] The time scale over which adaptation builds up and recovers depends on the time course of stimulation. [2] Brief stimulation produces adaptation which occurs and recovers while more prolonged stimulation can produce slower and more lasting forms of adaptation. [2] Also, repeated sensory stimulation appears to temporarily decrease the gain of thalamocortical synaptic transmission. Adaptation of cortical responses was stronger and recovered more slowly. [2] Vastly different timescales of adaptation have also been shown to be implemented on the single neuron level, where they can give rise to time-scale free adaptation. [5]

History

In the late 1800s, Hermann Helmholtz, a German physician and physicist, extensively researched conscious sensations and different types of perception. He defined sensations as the "raw elements" of conscious experience that required no learning, and perceptions as the meaningful interpretations derived from the senses. He studied the physical properties of the eye and vision, as well as acoustic sensation. In one of his classic experiments regarding how space perception could be altered by experience, participants wore glasses that distorted the visual field by several degrees to the right. Participants were asked to look at an object, close their eyes, and try to reach out and touch it. At first, the subjects reached for the object too far to the left, but after a few trials were able to correct themselves.

Prismatic reversing glasses (upside down goggles with two prisms) Blinking in Upside Down Goggles.gif
Prismatic reversing glasses (upside down goggles with two prisms)

Helmholtz theorized that perceptual adaptation might result from a process he referred to as unconscious inference, where the mind unconsciously adopts certain rules in order to make sense of what is perceived of the world. An example of this phenomenon is when a ball appears to be getting smaller and smaller, the mind will then infer that the ball is moving away from them.

In the 1890s, psychologist George M. Stratton conducted experiments in which he tested the theory of perceptual adaptation. In one experiment, he wore a reversing glasses for 21½ hours over three days. After removing the glasses, "normal vision was restored instantaneously and without any disturbance in the natural appearance or position of objects." [6]

Modern version of inverting mirrors with harness Stratton glasses experiment (modern version).jpg
Modern version of inverting mirrors with harness

On a later experiment, Stratton wore the glasses for eight whole days. By day four, the images seen through the instrument were still upside down. However, on day five, images appeared upright until he concentrated on them; then they became inverted again. By having to concentrate on his vision to turn it upside down again, especially when he knew images were hitting his retinas in the opposite orientation as normal, Stratton deduced his brain had adapted to the changes in vision.

Stratton also conducted experiments where he wore glasses that altered his visual field by 45°. His brain was able to adapt to the change and perceive the world as normal. Also, the field can be altered making the subject see the world upside down. But, as the brain adjusts to the change, the world appears "normal." [7] [8]

In some extreme experiments, psychologists have tested to see if a pilot can fly a plane with altered vision. All of the pilots that were fitted with the goggles that altered their vision were able to safely navigate the aircraft with ease. [7]

Visual

Adaptation is considered to be the cause of perceptual phenomena like afterimages and the motion aftereffect. In the absence of fixational eye movements, visual perception may fade out or disappear due to neural adaptation. (See Adaptation (eye)). [9] When an observer's visual stream adapts to a single direction of real motion, imagined motion can be perceived at various speeds. If the imagined motion is in the same direction as that experienced during adaptation, imagined speed is slowed; when imagined motion is in the opposite direction, its speed is increased; when adaptation and imagined motions are orthogonal, imagined speed is unaffected. [10] Studies using magnetoencephalography (MEG) have demonstrated that subjects exposed to a repeated visual stimulus at brief intervals become attenuated to the stimulus in comparison to the initial stimulus. The results revealed that visual responses to the repeated compared with novel stimulus showed a significant reduction in both activation strength and peak latency but not in the duration of neural processing. [11]

Although motion and images are extremely important regarding adaptation, the most important adaptation is adjusting to brightness levels. On entering a dark room or a very brightly lit room it takes a little while to adjust to the different levels. Adjusting to brightness levels allows mammals to detect changes in their surrounding. This is called dark adaptation.

Auditory

Auditory adaptation, as perceptual adaptation with other senses, is the process by which individuals adapt to sounds and noises. As research has shown, as time progresses, individuals tend to adapt to sounds and tend to distinguish them less frequently after a while. Sensory adaptation tends to blend sounds into one, variable sound, rather than having several separate sounds as a series. Moreover, after repeated perception, individuals tend to adapt to sounds to the point where they no longer consciously perceive it, or rather, "block it out". An individual that lives close to the train tracks, will eventually stop noticing the sounds of passing trains. Similarly, individuals living in larger cities no longer notice traffic sounds after a while. Moving to a completely different area, such as a quiet countryside, that individual would then be aware of the silence, crickets, etc. [12]

The mechanoreception of sound requires a specific set of receptor cells called hair cells that allow for gradient signals to pass onto spatial ganglia where the signal will be sent to the brain to be processed. Since this is mechanoreception, different from chemoreception, adaptation of sound from surroundings highly depends on the physical movement of opening and closing of cation channels on the hair cell stereocilia. Mechanoelectric transduction (MET) channels, located at the tops of stereocilia, are poised to detect tension induced by hair bundle deflection. Hair bundle deflection generates a force by pulling on tip link proteins connecting adjacent stereocilia. [13]

Olfactory

Perceptual adaptation is a phenomenon that occurs for all of the senses, including smell and touch. An individual can adapt to a certain smell with time. Smokers, or individuals living with smokers, tend to stop noticing the smell of cigarettes after some time, whereas people not exposed to smoke on a regular basis will notice the smell instantly. The same phenomenon can be observed with other types of smell, such as perfume, flowers, etc. The human brain can distinguish smells that are unfamiliar to the individual, while adapting to those it is used to and no longer require to be consciously recognized. [14]

Olfactory neurons utilize a feedback system from the levels of Ca2+ions to activate its adaptation to prolonged smells. Due to the fact that the olfactory signal transduction uses a second messenger transduction system, the mechanism of adaptation includes several factors that mostly include CaMK or calmodulin bound to Ca2+ions. [15]

Somatosensory

This phenomenon also applies to the sense of touch. An unfamiliar piece of clothing that was just put on will be noticed instantly; however, once it has been worn for a while, the mind will adapt to its texture and ignore the stimulus. [16]

Pain

While large mechanosensory neurons such as type I/group Aß display adaptation, smaller type IV/group C nociceptive neurons do not. As a result, pain does not usually subside rapidly but persists for long periods of time; in contrast, other sensory information is quickly adapted to, if surroundings remain constant.

Weight training

Studies have shown that there is neural adaptation after as little as one weight training session. Strength gains are experienced by subjects without any increased muscle size. Muscle surface recordings using electromyographic (SEMG) techniques have found that early strength gains throughout training are associated with increased amplitude in SEMG activity. These findings along with various other theories explain increases in strength without increases in muscle mass. Other theories for increases in strength relating to neural adaptation include: agonist-antagonist muscle decreased co-activation, motor unit synchronization, and motor unit increased firing rates. [17]

Neural adaptations contribute to changes in V-waves and Hoffmann's reflex. H-reflex can be used to assess the excitability of spinal α-motoneurons, whereas V-wave measures the magnitude of motor output from α-motoneurons. Studies showed that after a 14-week resistance training regime, subjects expressed V-wave amplitude increases of ~50% and H-reflex amplitude increases of ~20%. [18] This showed that neural adaptation accounts for changes to functional properties of the spinal cord circuitry in humans without affecting organization of the motor cortex. [19]

Habituation vs. adaptation

The terms neural adaptation and habituation are often confused for one another. Habituation is a behavioral phenomenon while neural adaptation is a physiological phenomenon, although the two are not entirely separate. During habituation, one has some conscious control over whether one notices something to which one is becoming habituated. However, when it comes to neural adaptation, one has no conscious control over it. For example, if one has adapted to something (like an odor or perfume), one can not consciously force themselves to smell that thing. Neural adaptation is tied very closely to stimulus intensity; as the intensity of a light increases, one's senses will adapt more strongly to it. [20] In comparison, habituation can vary depending on the stimulus. With a weak stimulus habituation can occur almost immediately but with a strong stimulus the animal may not habituate at all [21] e.g. a cool breeze versus a fire alarm. Habituation also has a set of characteristics that must be met to be termed a habituation process. [22]

Rhythmic behaviors

Short-term adaptations

Short term neural adaptations occur in the body during rhythmic activities. One of the most common activities when these neural adaptations are constantly happening is walking. [23] As a person walks, the body constantly gathers information about the environment and the surroundings of the feet, and slightly adjusts the muscles in use according to the terrain. For example, walking uphill requires different muscles than walking on flat pavement. When the brain recognizes that the body is walking uphill, it makes neural adaptations that send more activity to muscles required for uphill walking. The rate of neural adaptation is affected by the area of the brain and by the similarity between sizes and shapes of previous stimuli. [24] Adaptations in the inferior temporal gyrus are very dependent on previous stimuli being of similar size, and somewhat dependent on previous stimuli being of a similar shape. Adaptations in the prefrontal cortex are less dependent on previous stimuli being of similar size and shape.

Long-term adaptations

Some rhythmic movements, such as respiratory movements, are essential for survival. Because these movements must be used over the course of the entire lifetime, it is important for them to function optimally. Neural adaptation has been observed in these movements in response to training or altered external conditions. [23] Animals have been shown to have reduced breathing rates in response to better fitness levels. Since breathing rates were not conscious changes made by the animal, it is presumed that neural adaptations occur for the body to maintain a slower breathing rate.

Transcranial magnetic stimulation

Transcranial magnetic stimulation (TMS) is an important technique in modern cognitive neuropsychology that is used to investigate the perceptual and behavioral effects of temporary interference of neural processing. Studies have shown that when a subject's visual cortex is disrupted by TMS, the subject views colorless flashes of light, or phosphenes. [25] When a subjects’ vision was subjected to the constant stimulus of a single color, neural adaptations occurred that made the subjects used to the color. Once this adaptation had occurred, TMS was used to disrupt the subjects’ visual cortex again, and the flashes of light viewed by the subject were the same color as the constant stimulus before the disruption.

Drug induced

Neural adaptation can occur for other than natural means. Antidepressant drugs, such as those that cause down regulation of β-adrenergic receptors, can cause rapid neural adaptations in the brain. [26] By creating a quick adaptation in the regulation of these receptors, it is possible for drugs to reduce the effects of stress on those taking the medication.

Post-injury

Neural adaptation is often critical for an animal's survival after an injury. In the short-term, it may alter an animal's movements so as to prevent worsening the injury. In the long-term, it may enable the animal's full or partial recovery from the injury.

Brain injury

Studies in children with early childhood brain injuries have shown that neural adaptations slowly occur after the injury. [27] Children with early injuries to the linguistics, spatial cognition and affective development areas of the brain showed deficits in those areas as compared to those without injury. Due to neural adaptations, however, by early school-age, considerable development to those areas was observed.

Leg injury

After the amputation of a front leg, the fruit fly (Drosophilamelanogaster) shows immediate changes in body position and walking kinematics that enable it to continue walking. [28] The fruit fly exhibits longer-term adaptations as well. Researchers found that immediately after amputating a hind leg, flies favored turning away from the side of the injury, but that after several days this bias went away, and the flies turned left and right evenly, as they had before the injury. [29] These researchers compared flies with functioning versus impaired proprioception — the body's sense of where it is in space — and found that without proprioception, flies did not exhibit the same recovery from a turning bias after injury. [29] This result indicates that proprioceptive information is necessary for some of the neural adaptation that occurs in Drosophila after a leg injury.

See also

Related Research Articles

<span class="mw-page-title-main">Perception</span> Interpretation of sensory information

Perception is the organization, identification, and interpretation of sensory information in order to represent and understand the presented information or environment. All perception involves signals that go through the nervous system, which in turn result from physical or chemical stimulation of the sensory system. Vision involves light striking the retina of the eye; smell is mediated by odor molecules; and hearing involves pressure waves.

An illusion is a distortion of the senses, which can reveal how the mind normally organizes and interprets sensory stimulation. Although illusions distort the human perception of reality, they are generally shared by most people.

<span class="mw-page-title-main">Sensory nervous system</span> Part of the nervous system responsible for processing sensory information

The sensory nervous system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory neurons, neural pathways, and parts of the brain involved in sensory perception and interoception. Commonly recognized sensory systems are those for vision, hearing, touch, taste, smell, balance and visceral sensation. Sense organs are transducers that convert data from the outer physical world to the realm of the mind where people interpret the information, creating their perception of the world around them.

<span class="mw-page-title-main">Olfactory bulb</span> Neural structure

The olfactory bulb is a neural structure of the vertebrate forebrain involved in olfaction, the sense of smell. It sends olfactory information to be further processed in the amygdala, the orbitofrontal cortex (OFC) and the hippocampus where it plays a role in emotion, memory and learning. The bulb is divided into two distinct structures: the main olfactory bulb and the accessory olfactory bulb. The main olfactory bulb connects to the amygdala via the piriform cortex of the primary olfactory cortex and directly projects from the main olfactory bulb to specific amygdala areas. The accessory olfactory bulb resides on the dorsal-posterior region of the main olfactory bulb and forms a parallel pathway. Destruction of the olfactory bulb results in ipsilateral anosmia, while irritative lesions of the uncus can result in olfactory and gustatory hallucinations.

<span class="mw-page-title-main">Stimulus (physiology)</span> Detectable change in the internal or external surroundings

In physiology, a stimulus is a detectable change in the physical or chemical structure of an organism's internal or external environment. The ability of an organism or organ to detect external stimuli, so that an appropriate reaction can be made, is called sensitivity (excitability). Sensory receptors can receive information from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanoreceptors. When a stimulus is detected by a sensory receptor, it can elicit a reflex via stimulus transduction. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level of strength must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to the central nervous system (CNS), where it is integrated and a decision on how to react is made. Although stimuli commonly cause the body to respond, it is the CNS that finally determines whether a signal causes a reaction or not.

Stimulus modality, also called sensory modality, is one aspect of a stimulus or what is perceived after a stimulus. For example, the temperature modality is registered after heat or cold stimulate a receptor. Some sensory modalities include: light, sound, temperature, taste, pressure, and smell. The type and location of the sensory receptor activated by the stimulus plays the primary role in coding the sensation. All sensory modalities work together to heighten stimuli sensation when necessary.

<span class="mw-page-title-main">Sensory neuron</span> Nerve cell that converts environmental stimuli into corresponding internal stimuli

Sensory neurons, also known as afferent neurons, are neurons in the nervous system, that convert a specific type of stimulus, via their receptors, into action potentials or graded receptor potentials. This process is called sensory transduction. The cell bodies of the sensory neurons are located in the dorsal ganglia of the spinal cord.

Multisensory integration, also known as multimodal integration, is the study of how information from the different sensory modalities may be integrated by the nervous system. A coherent representation of objects combining modalities enables animals to have meaningful perceptual experiences. Indeed, multisensory integration is central to adaptive behavior because it allows animals to perceive a world of coherent perceptual entities. Multisensory integration also deals with how different sensory modalities interact with one another and alter each other's processing.

<span class="mw-page-title-main">Escape response</span>

Escape response, escape reaction, or escape behavior is a mechanism by which animals avoid potential predation. It consists of a rapid sequence of movements, or lack of movement, that position the animal in such a way that allows it to hide, freeze, or flee from the supposed predator. Often, an animal's escape response is representative of an instinctual defensive mechanism, though there is evidence that these escape responses may be learned or influenced by experience.

A sensory cue is a statistic or signal that can be extracted from the sensory input by a perceiver, that indicates the state of some property of the world that the perceiver is interested in perceiving.

A topographic map is the ordered projection of a sensory surface, like the retina or the skin, or an effector system, like the musculature, to one or more structures of the central nervous system. Topographic maps can be found in all sensory systems and in many motor systems.

Olfactory fatigue, also known as odor fatigue, olfactory adaptation, and noseblindness, is the temporary, normal inability to distinguish a particular odor after a prolonged exposure to that airborne compound. For example, when entering a restaurant initially the odor of food is often perceived as being very strong, but after time the awareness of the odor normally fades to the point where the smell is not perceptible or is much weaker. After leaving the area of high odor, the sensitivity is restored with time. Anosmia is the permanent loss of the sense of smell, and is different from olfactory fatigue.

<span class="mw-page-title-main">Neural correlates of consciousness</span> Neuronal events sufficient for a specific conscious percept

The neural correlates of consciousness (NCC) refer to the relationships between mental states and neural states and constitute the minimal set of neuronal events and mechanisms sufficient for a specific conscious percept. Neuroscientists use empirical approaches to discover neural correlates of subjective phenomena; that is, neural changes which necessarily and regularly correlate with a specific experience. The set should be minimal because, under the materialist assumption that the brain is sufficient to give rise to any given conscious experience, the question is which of its components are necessary to produce it.

<span class="mw-page-title-main">Sense of smell</span> Sense that detects smells

The sense of smell, or olfaction, is the special sense through which smells are perceived. The sense of smell has many functions, including detecting desirable foods, hazards, and pheromones, and plays a role in taste.

Olfactory memory refers to the recollection of odors. Studies have found various characteristics of common memories of odor memory including persistence and high resistance to interference. Explicit memory is typically the form focused on in the studies of olfactory memory, though implicit forms of memory certainly supply distinct contributions to the understanding of odors and memories of them. Research has demonstrated that the changes to the olfactory bulb and main olfactory system following birth are extremely important and influential for maternal behavior. Mammalian olfactory cues play an important role in the coordination of the mother infant bond, and the following normal development of the offspring. Maternal breast odors are individually distinctive, and provide a basis for recognition of the mother by her offspring.

Extinction is a neurological disorder that impairs the ability to perceive multiple stimuli of the same type simultaneously. Extinction is usually caused by damage resulting in lesions on one side of the brain. Those who are affected by extinction have a lack of awareness in the contralesional side of space and a loss of exploratory search and other actions normally directed toward that side.

A sense is a biological system used by an organism for sensation, the process of gathering information about the world through the detection of stimuli. Although in some cultures five human senses were traditionally identified as such, many more are now recognized. Senses used by non-human organisms are even greater in variety and number. During sensation, sense organs collect various stimuli for transduction, meaning transformation into a form that can be understood by the brain. Sensation and perception are fundamental to nearly every aspect of an organism's cognition, behavior and thought.

Sensory maps are areas of the brain which respond to sensory stimulation, and are spatially organized according to some feature of the sensory stimulation. In some cases the sensory map is simply a topographic representation of a sensory surface such as the skin, cochlea, or retina. In other cases it represents other stimulus properties resulting from neuronal computation and is generally ordered in a manner that reflects the periphery. An example is the somatosensory map which is a projection of the skin's surface in the brain that arranges the processing of tactile sensation. This type of somatotopic map is the most common, possibly because it allows for physically neighboring areas of the brain to react to physically similar stimuli in the periphery or because it allows for greater motor control.

<span class="mw-page-title-main">Sniffing (behavior)</span> Nasal inhalation to sample odors

Sniffing is a perceptually-relevant behavior, defined as the active sampling of odors through the nasal cavity for the purpose of information acquisition. This behavior, displayed by all terrestrial vertebrates, is typically identified based upon changes in respiratory frequency and/or amplitude, and is often studied in the context of odor guided behaviors and olfactory perceptual tasks. Sniffing is quantified by measuring intra-nasal pressure or flow or air or, while less accurate, through a strain gauge on the chest to measure total respiratory volume. Strategies for sniffing behavior vary depending upon the animal, with small animals displaying sniffing frequencies ranging from 4 to 12 Hz but larger animals (humans) sniffing at much lower frequencies, usually less than 2 Hz. Subserving sniffing behaviors, evidence for an "olfactomotor" circuit in the brain exists, wherein perception or expectation of an odor can trigger brain respiratory center to allow for the modulation of sniffing frequency and amplitude and thus acquisition of odor information. Sniffing is analogous to other stimulus sampling behaviors, including visual saccades, active touch, and whisker movements in small animals. Atypical sniffing has been reported in cases of neurological disorders, especially those disorders characterized by impaired motor function and olfactory perception.

Binocular switch suppression (BSS) is a technique to suppress usually salient images from an individual's awareness, a type of experimental manipulation used in visual perception and cognitive neuroscience. In BSS, two images of differing signal strengths are repetitively switched between the left and right eye at a constant rate of 1 Hertz. During this process of switching, the image of lower contrast and signal strength is perceptually suppressed for a period of time.

References

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  29. 1 2 Isakov, Alexander; Buchanan, Sean M.; Sullivan, Brian; Ramachandran, Akshitha; Chapman, Joshua K. S.; Lu, Edward S.; Mahadevan, L.; de Bivort, Benjamin (2016-06-01). "Recovery of locomotion after injury in Drosophila melanogaster depends on proprioception". The Journal of Experimental Biology. 219 (11): 1760–1771. doi: 10.1242/jeb.133652 . ISSN   0022-0949. PMID   26994176.
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