Neurotrimin

NTM
Identifiers
Aliases	NTM , HNT, IGLON2, NTRI, neurotrimin, CEPU-1
External IDs	OMIM: 607938; MGI: 2446259; HomoloGene: 41139; GeneCards: NTM; OMA:NTM - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q25 Start 131,370,478 bp [1] End 132,336,822 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A4 Start 28,906,046 bp [2] End 29,874,437 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum cerebellar vermis primary visual cortex middle temporal gyrus postcentral gyrus Brodmann area 23 superior frontal gyrus corpus callosum right frontal lobe Brodmann area 9 Top expressed in primary motor cortex visual cortex cerebellar cortex primary visual cortex cerebellar vermis lobe of cerebellum superior frontal gyrus prefrontal cortex mammillary body lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component anchored component of membrane membrane extracellular region plasma membrane Biological process neuron recognition cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50863 235106 Ensembl ENSG00000182667 ENSMUSG00000059974 UniProt Q9P121 Q99PJ0 RefSeq (mRNA) NM_001048209 NM_001144058 NM_001144059 NM_016522 NM_001352001 NM_001352002 NM_001352003 NM_001352004 NM_001352005 NM_001352006 NM_001352007 NM_001352008 NM_001352009 NM_172290 NM_001357593 NM_001357597 NM_001357598 NM_001357601 NM_001357602 NM_001357603 RefSeq (protein) NP_001041674 NP_001137530 NP_001137531 NP_057606 NP_001338930 NP_001338931 NP_001338932 NP_001338933 NP_001338934 NP_001338935 NP_001338936 NP_001338937 NP_001338938 NP_758494 NP_001344522 NP_001344526 NP_001344527 NP_001344530 NP_001344531 NP_001344532 Location (UCSC) Chr 11: 131.37 – 132.34 Mb Chr 9: 28.91 – 29.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neurotrimin is a protein that in humans is encoded by the NTM gene. ^{[5] [6]}

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML) on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000182667 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059974 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (Apr 1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J Neurosci. 15 (3 Pt 2): 2141–56. doi: 10.1523/JNEUROSCI.15-03-02141.1995 . PMC   6578143 . PMID   7891157.
6. "Entrez Gene: HNT neurotrimin".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID   12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID   12819783. S2CID   24411276.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Liu J, Li G, Peng X, et al. (2004). "The cloning and preliminarily functional analysis of the human neurotrimin gene". Science in China Series C: Life Sciences. 47 (2): 158–64. doi:10.1360/03yc0072. PMID   15379248. S2CID   12684887.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.