OSTalpha

SLC51A
Identifiers
Aliases	SLC51A , OSTA, OSTalpha, solute carrier family 51 alpha subunit, solute carrier family 51 subunit alpha, PFIC6
External IDs	OMIM: 612084 MGI: 2146634 HomoloGene: 44941 GeneCards: SLC51A
Gene location (Human)
Chr.	Chromosome 3 (human)
End	196,243,178 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	32,306,697 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; jejunal mucosa; ; duodenum; ; sperm; ; Right adrenal gland; ; palpebral conjunctiva; ; bone marrow cells; ; gastrocnemius muscle; ; skin of abdomen; ; right uterine tube;
	Top expressed in
	ileum; ; intestinal villus; ; jejunum; ; duodenum; ; kidney; ; proximal tubule; ; crypt of lieberkuhn of small intestine; ; yolk sac; ; Paneth cell; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity ; protein heterodimerization activity ; bile acid transmembrane transporter activity ; transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; endoplasmic reticulum membrane ; endoplasmic reticulum ; membrane ; basolateral plasma membrane ; protein-containing complex ;
Biological process	bile acid and bile salt transport ; bile acid secretion ; transmembrane transport ; organic substance transport ;
	Sources:Amigo / QuickGO
Orthologs
	200931
	106407
	ENSG00000163959
	ENSMUSG00000035699
	Q86UW1
	Q8R000
	NM_152672
	NM_145932
	NP_689885
	NP_666044
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the SLC51A gene.^[5]^[6]

Function

OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.^[6]^[7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.^[7] The heterodimer furthermore is essential for intestinal bile acid transport.^[8]

OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.^[6]

Related Research Articles

Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene. SLC19A3 is a thiamine transporter.

Peptide transporter 1 also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.

A urea transporter is a membrane transport protein, transporting urea. Humans and other mammals have two types of urea transport proteins, UT-A and UT-B. The UT-A proteins are important for renal urea handling and are produced by alternative splicing of the SLC14A2 gene. Urea transport in the kidney is regulated by vasopressin.

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.

Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 (GLUT7) is a protein that in humans is encoded by the SLC2A7 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

Members of the organic solute transporter (OST) family have been characterized from a small bottom feeding species of fish called the little skate, Raja erinacea. Members have also been characterized from humans and mice. The OST family is a member of the larger group of secondary carriers, the APC superfamily.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163959 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035699 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: OSTalpha organic solute transporter alpha".
1 2 3 Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi: 10.1074/jbc.M301106200 . PMID 12719432.
1 2 Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi: 10.1074/jbc.M412752200 . PMC 1224727 . PMID 15563450.
↑ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi: 10.1073/pnas.0712328105 . PMC 2268840 . PMID 18292224.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi: 10.1074/jbc.M301106200 . PMID 12719432.
Dawson PA, Hubbert M, Haywood J, et al. (2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi: 10.1074/jbc.M412752200 . PMC 1224727 . PMID 15563450.
Lee H, Zhang Y, Lee FY, et al. (2006). "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine". J. Lipid Res. 47 (1): 201–14. doi: 10.1194/jlr.M500417-JLR200 . PMID 16251721.
Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G476–85. doi:10.1152/ajpgi.00430.2005. PMID 16269519. S2CID 8687386.
Ballatori N, Christian WV, Lee JY, et al. (2005). "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia". Hepatology. 42 (6): 1270–9. doi: 10.1002/hep.20961 . PMID 16317684. S2CID 55829915.
Boyer JL, Trauner M, Mennone A, et al. (2006). "Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (6): G1124–30. doi:10.1152/ajpgi.00539.2005. PMID 16423920. S2CID 86156271.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Sun AQ, Balasubramaniyan N, Xu K, et al. (2007). "Protein-protein interactions and membrane localization of the human organic solute transporter". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (6): G1586–93. doi:10.1152/ajpgi.00457.2006. PMID 17332473.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163959 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035699 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OSTalpha organic solute transporter alpha".

[pmid12719432-6] 1 2 3 Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi: 10.1074/jbc.M301106200 . PMID 12719432.

[pmid15563450-7] 1 2 Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi: 10.1074/jbc.M412752200 . PMC 1224727 . PMID 15563450.

[pmid18292224-8] Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi: 10.1073/pnas.0712328105 . PMC 2268840 . PMID 18292224.

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OSTalpha

Contents

Function

See also

Related Research Articles

References

Further reading