OSTbeta

SLC51B
Identifiers
Aliases	SLC51B , OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit, solute carrier family 51 subunit beta, PBAM2
External IDs	OMIM: 612085 MGI: 3582052 HomoloGene: 18721 GeneCards: SLC51B
Gene location (Human)
Chr.	Chromosome 15 (human)
End	65,053,397 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,330,237 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; jejunal mucosa; ; popliteal artery; ; right coronary artery; ; ascending aorta; ; kidney; ; left uterine tube; ; smooth muscle tissue; ; gastric mucosa;
	Top expressed in
	jejunum; ; ileum; ; proximal tubule; ; duodenum; ; kidney; ; Paneth cell; ; large intestine; ; colon; ; morula; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity ; protein heterodimerization activity ; bile acid transmembrane transporter activity ; transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ; basolateral plasma membrane ; protein-containing complex ;
Biological process	positive regulation of protein glycosylation ; regulation of protein stability ; positive regulation of protein exit from endoplasmic reticulum ; bile acid and bile salt transport ; positive regulation of protein targeting to membrane ; bile acid secretion ; transmembrane transport ; organic substance transport ;
	Sources:Amigo / QuickGO
Orthologs
	123264
	330962
	ENSG00000186198
	ENSMUSG00000053862
	Q86UW2
	Q80WK2
	NM_178859
	NM_178933
	NP_849190
	NP_849264
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 26, 2022

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.^[5]^[6]

Function

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.^[6]^[7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.^[7] The heterodimer furthermore is essential for intestinal bile acid transport.^[8]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.^[6]

Related Research Articles

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<span class="mw-page-title-main">Electroneutral sodium bicarbonate exchanger 1</span>

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

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Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the OSTA gene.

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Members of the organic solute transporter (OST) family have been characterized from a small bottom feeding species of fish called the little skate, Raja erinacea. Members have also been characterized from humans and mice. The OST family is a member of the larger group of secondary carriers, the APC superfamily.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186198 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053862 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: OSTbeta organic solute transporter beta".
1 2 3 Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi: 10.1074/jbc.M301106200 . PMID 12719432.
1 2 Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi: 10.1074/jbc.M412752200 . PMC 1224727 . PMID 15563450.
↑ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi: 10.1073/pnas.0712328105 . PMC 2268840 . PMID 18292224.

Sun AQ, Balasubramaniyan N, Xu K, et al. (2007). "Protein-protein interactions and membrane localization of the human organic solute transporter". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (6): G1586–93. doi:10.1152/ajpgi.00457.2006. PMID 17332473.
Boyer JL, Trauner M, Mennone A, et al. (2006). "Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (6): G1124–30. doi:10.1152/ajpgi.00539.2005. PMID 16423920. S2CID 86156271.
Ballatori N, Christian WV, Lee JY, et al. (2005). "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia". Hepatology. 42 (6): 1270–9. doi: 10.1002/hep.20961 . PMID 16317684.
Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G476–85. doi:10.1152/ajpgi.00430.2005. PMID 16269519. S2CID 8687386.
Lee H, Zhang Y, Lee FY, et al. (2006). "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine". J. Lipid Res. 47 (1): 201–14. doi: 10.1194/jlr.M500417-JLR200 . PMID 16251721.
Dawson PA, Hubbert M, Haywood J, et al. (2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi: 10.1074/jbc.M412752200 . PMC 1224727 . PMID 15563450.
Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi: 10.1074/jbc.M301106200 . PMID 12719432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186198 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053862 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OSTbeta organic solute transporter beta".

[pmid12719432-6] 1 2 3 Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi: 10.1074/jbc.M301106200 . PMID 12719432.

[pmid15563450-7] 1 2 Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi: 10.1074/jbc.M412752200 . PMC 1224727 . PMID 15563450.

[pmid18292224-8] Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi: 10.1073/pnas.0712328105 . PMC 2268840 . PMID 18292224.

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OSTbeta

Contents

Function

See also

Related Research Articles

References

Further reading