Ovomucoid

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Ovomucoid
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The third Kazal domain of the turkey ovomucoid protein (orange) bound to subtilisin Carlsberg, a serine protease. [1]
Identifiers
Organism Meleagris gallopavo
Symbol?
UniProt P68390
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Structures Swiss-model
Domains InterPro
Ovomucoid
Identifiers
Organism Gallus gallus
Symbol?
UniProt P01005
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Structures Swiss-model
Domains InterPro

Ovomucoid is a protein found in egg whites. It is a trypsin inhibitor with three protein domains of the Kazal domain family. [2] [3] The homologs from chickens (Gallus gallus) and especially turkeys (Meleagris gallopavo) are best characterized. It is not related to the similarly named ovomucin, another egg white protein.

Chicken ovomucoid, also known as Gal d 1, is a known allergen. It is the protein most often causing egg allergy. At least four IgE epitopes have been identified. [4] Three other egg white proteins are also identified as allergenic: ovalbumin (Gal d 2), ovotransferrin (Gal d 3) and lysozyme (Gal d 4). [5]

References

  1. ↑ Horn JR, Ramaswamy S, Murphy KP (August 2003). "Structure and energetics of protein-protein interactions: the role of conformational heterogeneity in OMTKY3 binding to serine proteases". Journal of Molecular Biology. 331 (2): 497–508. doi:10.1016/S0022-2836(03)00783-6. PMID   12888355.
  2. ↑ Lineweaver H, Murray CW (December 1947). "Identification of the trypsin inhibitor of egg white with ovomucoid". The Journal of Biological Chemistry. 171 (2): 565–81. doi: 10.1016/S0021-9258(17)41067-2 . PMID   20272096.
  3. ↑ Rimphanitchayakit V, Tassanakajon A (April 2010). "Structure and function of invertebrate Kazal-type serine proteinase inhibitors". Developmental and Comparative Immunology. 34 (4): 377–86. doi:10.1016/j.dci.2009.12.004. PMID   19995574.
  4. ↑ Järvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA (July 2007). "Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy". Allergy. 62 (7): 758–65. doi:10.1111/j.1398-9995.2007.01332.x. PMID   17573723. S2CID   23540584.
  5. ↑ Caubet JC, Wang J (2011). "Current understanding of egg allergy". Pediatr. Clin. North Am. 58 (2): 427–43, xi. doi:10.1016/j.pcl.2011.02.014. PMC   3069662 . PMID   21453811.


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