PARC (gene)

CUL9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JUF
Identifiers
Aliases	CUL9 , H7AP1, PARC, 1810035I07Rik, Cul-9, mKIAA0708, cullin 9
External IDs	OMIM: 607489 MGI: 1925559 HomoloGene: 56696 GeneCards: CUL9
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,224,587 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,857,314 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right lobe of thyroid gland; ; skin of abdomen; ; spleen; ; putamen; ; left lobe of thyroid gland; ; nucleus accumbens; ; cingulate gyrus; ; Brodmann area 9; ; caudate nucleus;
	Top expressed in
	superior frontal gyrus; ; spermatocyte; ; cerebellar cortex; ; proximal tubule; ; upper arm; ; islet of Langerhans; ; spermatid; ; lip; ; mirror; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; protein binding ; ATP binding ; ubiquitin protein ligase binding ; metal ion binding ; transferase activity ;
Cellular component	cytoplasm ; cullin-RING ubiquitin ligase complex ; cytosol ;
Biological process	microtubule cytoskeleton organization ; ubiquitin-dependent protein catabolic process ; regulation of mitotic nuclear division ; protein ubiquitination ; post-translational protein modification ;
	Sources:Amigo / QuickGO
Orthologs
	23113
	78309
	ENSG00000112659
	ENSMUSG00000040327
	Q8IWT3
	Q80TT8
	NM_015089
	NM_001081335
	NP_055904
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.^[5]^[6]^[7]^[8]

Interactions

PARC (gene) has been shown to interact with P53.^[7]

Related Research Articles

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.

AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene. The protein is a member of the FKBP family.

Cullin-2 is a protein that in humans is encoded by the CUL2 gene.

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1, is a human gene.

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.

Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112659 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040327 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA (Mar 2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi: 10.1158/0008-5472.CAN-06-3241 . PMID 17332328.
↑ Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (Nov 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi: 10.1074/jbc.274.43.30963 . PMID 10521492.
1 2 Nikolaev AY, Li M, Puskas N, Qin J, Gu W (Jan 2003). "Parc: a cytoplasmic anchor for p53". Cell. 112 (1): 29–40. doi: 10.1016/S0092-8674(02)01255-2 . PMID 12526791. S2CID 18403676.
↑ "Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein".

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Issaeva N, Bozko P, Enge M, et al. (2005). "Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors". Nat. Med. 10 (12): 1321–8. doi:10.1038/nm1146. PMID 15558054. S2CID 82043.
Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi: 10.1074/jbc.C600041200 . PMID 16672220.
Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi: 10.1074/jbc.M611297200 . PMID 17298945.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112659 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040327 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17332328-5] Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA (Mar 2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi: 10.1158/0008-5472.CAN-06-3241 . PMID 17332328.

[pmid10521492-6] Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (Nov 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi: 10.1074/jbc.274.43.30963 . PMID 10521492.

[pmid12526791-7] 1 2 Nikolaev AY, Li M, Puskas N, Qin J, Gu W (Jan 2003). "Parc: a cytoplasmic anchor for p53". Cell. 112 (1): 29–40. doi: 10.1016/S0092-8674(02)01255-2 . PMID 12526791. S2CID 18403676.

[entrez-8] "Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

PARC (gene)

Contents

Interactions

Related Research Articles

References

Further reading