PCBP4

PCBP4
Identifiers
Aliases	PCBP4 , CBP, LIP4, MCG10, poly(rC) binding protein 4
External IDs	OMIM: 608503 MGI: 1890471 HomoloGene: 56926 GeneCards: PCBP4
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.2 Start 51,957,454 bp [1] End 51,974,016 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 106,453,291 bp [2] End 106,464,012 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve sural nerve gastrocnemius muscle ganglionic eminence amygdala hypothalamus inferior ganglion of vagus nerve cingulate gyrus Brodmann area 9 inferior olivary nucleus Top expressed in cerebellar cortex cerebellar vermis retinal pigment epithelium medial ganglionic eminence somite abdominal wall superior frontal gyrus pontine nuclei lateral hypothalamus dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleic acid binding mRNA 3'-UTR binding RNA binding Cellular component cytoplasm cytosol Biological process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of mRNA stability Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57060 59092 Ensembl ENSG00000090097 ENSMUSG00000023495 UniProt P57723 P57724 RefSeq (mRNA) NM_001174100 NM_020418 NM_033008 NM_033009 NM_033010 NM_021567 RefSeq (protein) NP_001167571 NP_065151 NP_127501 NP_127503 NP_001350814 NP_067542 Location (UCSC) Chr 3: 51.96 – 51.97 Mb Chr 9: 106.45 – 106.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene. ^{[5] [6]}

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000090097 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023495 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Makeyev AV, Liebhaber SA (Sep 2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". Genomics. 67 (3): 301–16. doi:10.1006/geno.2000.6244. PMID   10936052.
6. "Entrez Gene: PCBP4 poly(rC) binding protein 4".

Further reading

• Taylor WR, Stark GR (2001). "Regulation of the G2/M transition by p53". Oncogene. 20 (15): 1803–15. doi: 10.1038/sj.onc.1204252 . PMID   11313928.
• Makeyev AV, Liebhaber SA (2002). "The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms". RNA. 8 (3): 265–78. doi:10.1017/S1355838202024627. PMC   1370249 . PMID   12003487.
• Kiledjian M, Wang X, Liebhaber SA (1995). "Identification of two KH domain proteins in the alpha-globin mRNP stability complex". EMBO J. 14 (17): 4357–64. doi:10.1002/j.1460-2075.1995.tb00110.x. PMC   394520 . PMID   7556077.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhu J, Chen X (2000). "MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M". Mol. Cell. Biol. 20 (15): 5602–18. doi:10.1128/MCB.20.15.5602-5618.2000. PMC   86022 . PMID   10891498.
• Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC   2039936 . PMID   11984006.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chkheidze AN, Liebhaber SA (2003). "A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins". Mol. Cell. Biol. 23 (23): 8405–15. doi:10.1128/MCB.23.23.8405-8415.2003. PMC   262676 . PMID   14612387.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.