PCDH8

PCDH8
Identifiers
Aliases	PCDH8 , ARCADLIN, PAPC, protocadherin 8
External IDs	OMIM: 603580; MGI: 1306800; HomoloGene: 1943; GeneCards: PCDH8; OMA:PCDH8 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.3 Start 52,842,889 bp [1] End 52,848,641 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 D3|14 42.76 cM Start 80,004,215 bp [2] End 80,008,752 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 frontal pole endothelial cell middle temporal gyrus Brodmann area 10 dorsolateral prefrontal cortex primary visual cortex Brodmann area 9 superior frontal gyrus nucleus accumbens Top expressed in anterior amygdaloid area lateral septal nucleus substantia nigra subiculum Region I of hippocampus proper superior colliculus dorsomedial hypothalamic nucleus ventral tegmental area paraventricular nucleus of hypothalamus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component cell projection cell junction postsynaptic membrane plasma membrane membrane presynaptic membrane integral component of membrane synapse dendrite integral component of plasma membrane glutamatergic synapse integral component of postsynaptic membrane Biological process morphogenesis of embryonic epithelium somitogenesis chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules cell-cell signaling cell adhesion nervous system development regulation of synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5100 18530 Ensembl ENSG00000136099 ENSMUSG00000036422 UniProt O95206 Q7TSK3 RefSeq (mRNA) NM_032949 NM_002590 NM_001042726 NM_021543 RefSeq (protein) NP_002581 NP_116567 NP_001036191 NP_067518 Location (UCSC) Chr 13: 52.84 – 52.85 Mb Chr 14: 80 – 80.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene. ^{[5] [6] [7]}

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000136099 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036422 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics. 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID   9787079.
6. Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol. 17 (10): 6157–66. doi:10.1128/MCB.17.10.6157. PMC   232466 . PMID   9315676.
7. "Entrez Gene: PCDH8 protocadherin 8".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi: 10.1101/gad.14.10.1169 . PMID   10817752. S2CID   44844497.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID   10835267.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi: 10.1016/S0092-8674(00)80789-8 . PMID   10380929. S2CID   6014717.
• Yamagata K, Andreasson KI, Sugiura H, et al. (1999). "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation". J. Biol. Chem. 274 (27): 19473–1979. doi: 10.1074/jbc.274.27.19473 . PMID   10383464.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi: 10.1073/pnas.060027397 . PMC   16203 . PMID   10716726.
• Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC   311048 . PMID   11230163.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bray NJ, Kirov G, Owen RJ, et al. (2003). "Screening the human protocadherin 8 (PCDH8) gene in schizophrenia". Genes, Brain and Behavior . 1 (3): 187–91. doi: 10.1034/j.1601-183X.2002.10307.x . PMID   12884975.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.