PDCD7

PDCD7
Identifiers
Aliases	PDCD7 , ES18, HES18, programmed cell death 7, 59K
External IDs	OMIM: 608138 MGI: 1859170 HomoloGene: 4170 GeneCards: PDCD7
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q22.31 Start 65,117,379 bp [1] End 65,133,808 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 C Start 65,253,386 bp [2] End 65,266,925 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte nipple superior surface of tongue thymus external globus pallidus medulla oblongata caput epididymis synovial membrane trigeminal ganglion ventral tegmental area Top expressed in secondary oocyte spermatocyte soleus muscle corneal stroma seminiferous tubule endocardial cushion extensor digitorum longus muscle gastrocnemius muscle thymus cerebellar cortex More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10081 50996 Ensembl ENSG00000090470 ENSMUSG00000041837 UniProt Q8N8D1 Q9WTY1 RefSeq (mRNA) NM_005707 NM_016688 RefSeq (protein) NP_005698 n/a Location (UCSC) Chr 15: 65.12 – 65.13 Mb Chr 9: 65.25 – 65.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene. ^{[5] [6]}

This gene encodes a protein with sequence similarity to a mouse protein originally identified in embryonic stem cells. In mouse T-cell lines, this protein appears to be related to glucocorticoid- and staurine-induced apoptotic pathways, and to be linked to ceramide-mediated signalling. These observations suggest that this gene product is involved in specific apoptotic processes in T-cells. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000090470 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041837 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH (Apr 1999). "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells". Nucleic Acids Res. 27 (6): 1524–30. doi:10.1093/nar/27.6.1524. PMC   148348 . PMID   10037816.
6. "Entrez Gene: PDCD7 programmed cell death 7".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC   1370585 . PMID   15146077.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.

External links

• PDCD7 human gene location in the UCSC Genome Browser .
• PDCD7 human gene details in the UCSC Genome Browser .