PEX11B

PEX11B
Identifiers
Aliases	PEX11B , PEX11-BETA, PEX14B, peroxisomal biogenesis factor 11 beta, PEX11beta
External IDs	OMIM: 603867; MGI: 1338882; HomoloGene: 2852; GeneCards: PEX11B; OMA:PEX11B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.1 Start 145,911,350 bp [1] End 145,918,717 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 96,542,692 bp [2] End 96,552,682 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 internal globus pallidus palpebral conjunctiva cingulate gyrus right frontal lobe nucleus accumbens anterior cingulate cortex mucosa of transverse colon caudate nucleus Top expressed in spermatocyte spermatid right kidney dentate gyrus of hippocampal formation granule cell muscle of thigh lip entorhinal cortex primary visual cortex perirhinal cortex CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity Cellular component integral component of membrane peroxisomal membrane peroxisome extracellular exosome membrane integral component of peroxisomal membrane mitochondrion protein-containing complex Biological process regulation of peroxisome size peroxisome organization protein homooligomerization signal transduction peroxisome fission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8799 18632 Ensembl ENSG00000131779 ENSMUSG00000028102 UniProt O96011 Q9Z210 RefSeq (mRNA) NM_001184795 NM_003846 NM_001162387 NM_001162388 NM_011069 RefSeq (protein) NP_001171724 NP_003837 NP_001155859 NP_001155860 NP_035199 Location (UCSC) Chr 1: 145.91 – 145.92 Mb Chr 3: 96.54 – 96.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene. ^{[5] [6]} It is involved in the regulation of peroxisome abundance. ^[7]

Interactions

PEX11B has been shown to interact with PEX19. ^{[8] [9]}

Related gene problems

• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000131779 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028102 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi: 10.1074/jbc.273.45.29607 . PMID   9792670.
6. "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".
7. Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID   16218949. S2CID   33237347.
8. Sacksteder KA, Jones J M, South S T, Li X, Liu Y, Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN   0021-9525. PMC   2174547 . PMID   10704444.
9. Fransen M, Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN   0270-7306. PMC   87101 . PMID   11390669.

Further reading

• Abe I, Fujiki Y (1998). "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p". Biochem. Biophys. Res. Commun. 252 (2): 529–33. doi:10.1006/bbrc.1998.9684. PMID   9826565.
• Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC   2174547 . PMID   10704444.
• Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi: 10.1074/mcp.M100025-MCP200 . PMID   12096124.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Li X, Gould SJ (2003). "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11". J. Biol. Chem. 278 (19): 17012–20. doi: 10.1074/jbc.M212031200 . PMID   12618434.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Exp. Cell Res. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID   17408615.