PEX11B

Last updated
PEX11B
Identifiers
Aliases PEX11B , PEX11-BETA, PEX14B, peroxisomal biogenesis factor 11 beta, PEX11beta
External IDs OMIM: 603867 MGI: 1338882 HomoloGene: 2852 GeneCards: PEX11B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001184795
NM_003846

NM_001162387
NM_001162388
NM_011069

RefSeq (protein)

NP_001171724
NP_003837

NP_001155859
NP_001155860
NP_035199

Location (UCSC) Chr 1: 145.91 – 145.92 Mb Chr 3: 96.54 – 96.55 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene. [5] [6] It is involved in the regulation of peroxisome abundance. [7]

Contents


Interactions

PEX11B has been shown to interact with PEX19. [8] [9]

Related Research Articles

<span class="mw-page-title-main">Peroxisome</span> Type of organelle

A peroxisome (IPA:[pɛɜˈɹɒksɪˌsoʊm]) is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. Peroxisomes are oxidative organelles. Frequently, molecular oxygen serves as a co-substrate, from which hydrogen peroxide (H2O2) is then formed. Peroxisomes owe their name to hydrogen peroxide generating and scavenging activities. They perform key roles in lipid metabolism and the reduction of reactive oxygen species.

In biochemical protein targeting, a peroxisomal targeting signal (PTS) is a region of the peroxisomal protein that receptors recognize and bind to. It is responsible for specifying that proteins containing this motif are localised to the peroxisome.

<span class="mw-page-title-main">PEX5</span> Protein-coding gene in the species Homo sapiens

Peroxisomal targeting signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene.

<span class="mw-page-title-main">PEX1</span> Protein-coding gene in the species Homo sapiens

Peroxisome biogenesis factor 1, also known as PEX1, is a protein which in humans is encoded by the PEX1 gene.

<span class="mw-page-title-main">PEX19</span> Protein-coding gene in the species Homo sapiens

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.

<span class="mw-page-title-main">PEX14</span> Protein-coding gene in the species Homo sapiens

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.

<span class="mw-page-title-main">ABCD3</span> Protein-coding gene in the species Homo sapiens

ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene.

<span class="mw-page-title-main">Peroxisomal biogenesis factor 2</span> Protein found in humans

Peroxisomal biogenesis factor 2 is a protein that in humans is encoded by the PEX2 gene.

<span class="mw-page-title-main">PEX12</span> Protein-coding gene in humans

Peroxisome assembly protein 12 is a protein that in humans is encoded by the PEX12 gene.

<span class="mw-page-title-main">PEX13</span> Protein-coding gene in the species Homo sapiens

Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. It located on chromosome 2 next to KIAA1841

<span class="mw-page-title-main">ACOT8</span> Protein-coding gene in the species Homo sapiens

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.

<span class="mw-page-title-main">PEX3</span> Protein-coding gene in the species Homo sapiens

Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.

<span class="mw-page-title-main">PEX6</span> Protein-coding gene in the species Homo sapiens

Peroxisome assembly factor 2 is a protein that in humans is encoded by the PEX6 gene. PEX6 is an AAA ATPase that localizes to the peroxisome. PEX6 forms a hexamer with PEX1 and is recruited to the membrane by PEX26.

<span class="mw-page-title-main">PEX10</span> Protein-coding gene in the species Homo sapiens

Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene. Alternative splicing results in two transcript variants encoding different isoforms.

<span class="mw-page-title-main">Peroxisomal membrane protein PMP34</span> Protein found in humans

Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene.

<span class="mw-page-title-main">ABCD2</span> Protein-coding gene in humans

ATP-binding cassette sub-family D member 2 is a membrane pump/transporter protein that in humans is encoded by the ABCD2 gene.

<span class="mw-page-title-main">PEX16</span> Protein-coding gene in the species Homo sapiens

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.

<span class="mw-page-title-main">PEX26</span> Protein-coding gene in the species Homo sapiens

Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.

<span class="mw-page-title-main">PEX11A</span> Protein-coding gene in the species Homo sapiens

Peroxisomal membrane protein 11A is a protein that in humans is encoded by the PEX11A gene.

<span class="mw-page-title-main">PXMP4</span> Protein-coding gene in the species Homo sapiens

Peroxisomal membrane protein 4 is a protein that in humans is encoded by the PXMP4 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000131779 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028102 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi: 10.1074/jbc.273.45.29607 . PMID   9792670.
  6. "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".
  7. Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID   16218949.
  8. Sacksteder, K A; Jones J M; South S T; Li X; Liu Y; Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN   0021-9525. PMC   2174547 . PMID   10704444.
  9. Fransen, M; Wylin T; Brees C; Mannaerts G P; Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN   0270-7306. PMC   87101 . PMID   11390669.

Further reading