PEX11B

PEX11B
Identifiers
Aliases	PEX11B , PEX11-BETA, PEX14B, peroxisomal biogenesis factor 11 beta, PEX11beta
External IDs	OMIM: 603867 MGI: 1338882 HomoloGene: 2852 GeneCards: PEX11B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,918,717 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,552,682 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; internal globus pallidus; ; palpebral conjunctiva; ; cingulate gyrus; ; nucleus accumbens; ; caudate nucleus; ; Brodmann area 46; ; superior frontal gyrus; ; middle temporal gyrus;
	Top expressed in
	spermatocyte; ; spermatid; ; lip; ; entorhinal cortex; ; superior frontal gyrus; ; proximal tubule; ; interventricular septum; ; seminiferous tubule; ; temporal muscle; ; extensor digitorum longus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein homodimerization activity ;
Cellular component	integral component of membrane ; peroxisomal membrane ; peroxisome ; extracellular exosome ; membrane ; integral component of peroxisomal membrane ; mitochondrion ; protein-containing complex ;
Biological process	regulation of peroxisome size ; peroxisome organization ; protein homooligomerization ; signal transduction ; peroxisome fission ;
	Sources:Amigo / QuickGO
Orthologs
	8799
	18632
	ENSG00000131779
	ENSMUSG00000028102
	O96011
	Q9Z210
	NM_001184795 ; NM_003846
	NM_001162387 ; NM_001162388 ; NM_011069
	NP_001171724 ; NP_003837
	NP_001155859 ; NP_001155860 ; NP_035199
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene.^[5]^[6] It is involved in the regulation of peroxisome abundance. ^[7]

Interactions

PEX11B has been shown to interact with PEX19.^[8]^[9]

Related Research Articles

<span class="mw-page-title-main">Peroxisome</span> Type of organelle

A peroxisome (IPA:[pɛɜˈɹɒksɪˌsoʊm]) is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. Peroxisomes are oxidative organelles. Frequently, molecular oxygen serves as a co-substrate, from which hydrogen peroxide (H₂O₂) is then formed. Peroxisomes owe their name to hydrogen peroxide generating and scavenging activities. They perform key roles in lipid metabolism and the reduction of reactive oxygen species.

In biochemical protein targeting, a peroxisomal targeting signal (PTS) is a region of the peroxisomal protein that receptors recognize and bind to. It is responsible for specifying that proteins containing this motif are localised to the peroxisome.

Peroxisomal targeting signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene.

Peroxisome biogenesis factor 1, also known as PEX1, is a protein which in humans is encoded by the PEX1 gene.

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.

ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene.

Peroxisomal biogenesis factor 2 is a protein that in humans is encoded by the PEX2 gene.

Peroxisome assembly protein 12 is a protein that in humans is encoded by the PEX12 gene.

Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. It located on chromosome 2 next to KIAA1841

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.

Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.

Peroxisome assembly factor 2 is a protein that in humans is encoded by the PEX6 gene. PEX6 is an AAA ATPase that localizes to the peroxisome. PEX6 forms a hexamer with PEX1 and is recruited to the membrane by PEX26.

Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene. Alternative splicing results in two transcript variants encoding different isoforms.

Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene.

ATP-binding cassette sub-family D member 2 is a membrane pump/transporter protein that in humans is encoded by the ABCD2 gene.

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.

Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.

Peroxisomal membrane protein 11A is a protein that in humans is encoded by the PEX11A gene.

Peroxisomal membrane protein 4 is a protein that in humans is encoded by the PXMP4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131779 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028102 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi: 10.1074/jbc.273.45.29607 . PMID 9792670.
↑ "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".
↑ Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949.
↑ Sacksteder, K A; Jones J M; South S T; Li X; Liu Y; Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547 . PMID 10704444.
↑ Fransen, M; Wylin T; Brees C; Mannaerts G P; Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101 . PMID 11390669.

Abe I, Fujiki Y (1998). "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p". Biochem. Biophys. Res. Commun. 252 (2): 529–33. doi:10.1006/bbrc.1998.9684. PMID 9826565.
Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547 . PMID 10704444.
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi: 10.1074/mcp.M100025-MCP200 . PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Li X, Gould SJ (2003). "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11". J. Biol. Chem. 278 (19): 17012–20. doi: 10.1074/jbc.M212031200 . PMID 12618434.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Exp. Cell Res. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131779 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028102 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9792670-5] Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi: 10.1074/jbc.273.45.29607 . PMID 9792670.

[entrez-6] "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".

[pmid16218949-7] Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949.

[pmid10704444-8] Sacksteder, K A; Jones J M; South S T; Li X; Liu Y; Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547 . PMID 10704444.

[pmid11390669-9] Fransen, M; Wylin T; Brees C; Mannaerts G P; Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101 . PMID 11390669.

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PEX11B

Contents

Interactions

Related gene problems

Related Research Articles

References

Further reading