PEX19

PEX19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W85, 2WL8, 3AJB, 3MK4
Identifiers
Aliases	PEX19 , D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1, peroxisomal biogenesis factor 19
External IDs	OMIM: 600279 MGI: 1334458 HomoloGene: 134253 GeneCards: PEX19
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 160,276,807 bp [1] End 160,286,348 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 79.54 cM Start 171,954,322 bp [2] End 171,964,060 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle abdominal fat thoracic diaphragm subcutaneous adipose tissue islet of Langerhans right lobe of liver prefrontal cortex rectum left ventricle left adrenal gland Top expressed in yolk sac lip digastric muscle temporal muscle brown adipose tissue triceps brachii muscle sternocleidomastoid muscle proximal tubule interventricular septum skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peroxisome membrane class-1 targeting sequence binding protein N-terminus binding ATPase binding protein binding Cellular component cytoplasm integral component of membrane cytosol membrane peroxisomal membrane peroxisome nucleoplasm brush border membrane nucleus protein-containing complex Biological process protein targeting to peroxisome peroxisome organization protein stabilization peroxisome membrane biogenesis peroxisome fission protein import into peroxisome membrane transmembrane transport establishment of protein localization to peroxisome negative regulation of lipid binding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5824 19298 Ensembl ENSG00000162735 ENSMUSG00000003464 UniProt P40855 Q8VCI5 RefSeq (mRNA) NM_001131039 NM_001193644 NM_002857 NM_001159525 NM_023041 NM_001356513 NM_001356514 RefSeq (protein) NP_001180573 NP_002848 NP_001152997 NP_075528 NP_001343442 NP_001343443 Location (UCSC) Chr 1: 160.28 – 160.29 Mb Chr 1: 171.95 – 171.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene. ^{[5] [6] [7]}

Interactions

PEX19 has been shown to interact with:

• ABCD1, ^{[8] [9]}
• ABCD2, ^{[8] [9]}
• ABCD3, ^{[8] [9] [10] [11]}
• PEX10, ^{[10] [12]}
• PEX11B, ^{[10] [12]}
• PEX12, ^{[10] [12]}
• PEX13, ^{[10] [12]}
• PEX16, ^[12] and
• PEX3. ^{[8] [10] [12] [13]}

References

1. GRCh38: Ensembl release 89: ENSG00000162735 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003464 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kammerer S, Arnold N, Gutensohn W, Mewes HW, Kunau WH, Höfler G, Roscher AA, Braun A (November 1997). "Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein". Genomics. 45 (1): 200–10. doi:10.1006/geno.1997.4914. PMID   9339377.
6. Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N, Fujiki Y (April 1999). "Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly". Proc Natl Acad Sci U S A. 96 (5): 2116–21. Bibcode:1999PNAS...96.2116M. doi: 10.1073/pnas.96.5.2116 . PMC   26746 . PMID   10051604.
7. "Entrez Gene: PEX19 peroxisomal biogenesis factor 19".
8. Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (March 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID   11883941.
9. Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (April 2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID   10777694.
10. Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC   2174547 . PMID   10704444.
11. Biermanns M, Gärtner J (July 2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID   11453642.
12. Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC   87101 . PMID   11390669.
13. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Braun A, Kammerer S, Weissenhorn W, Weiss EH, Cleve H (1994). "Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1". Gene. 146 (2): 291–5. doi:10.1016/0378-1119(94)90308-5. PMID   8076834.
• Götte K, Girzalsky W, Linkert M, Baumgart E, Kammerer S, Kunau WH, Erdmann R (1998). "Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis". Mol. Cell. Biol. 18 (1): 616–28. doi:10.1128/MCB.18.1.616. PMC   121529 . PMID   9418908.
• Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC   2174547 . PMID   10704444.
• Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID   10777694.
• Sugihara T, Kaul SC, Kato J, Reddel RR, Nomura H, Wadhwa R (2001). "Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway". J. Biol. Chem. 276 (22): 18649–52. doi: 10.1074/jbc.C100011200 . PMID   11259404.
• Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC   87101 . PMID   11390669.
• Biermanns M, Gärtner J (2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID   11453642.
• Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID   11883941.
• Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi: 10.1074/mcp.M100025-MCP200 . PMID   12096124.
• Ito M, Iidawa S, Izuka M, Haito S, Segawa H, Kuwahata M, Ohkido I, Ohno H, Miyamoto K (2004). "Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate". Biochem. J. 377 (Pt 3): 607–16. doi:10.1042/BJ20031223. PMC   1223893 . PMID   14558883.
• Jones JM, Morrell JC, Gould SJ (2004). "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins". J. Cell Biol. 164 (1): 57–67. doi:10.1083/jcb.200304111. PMC   2171958 . PMID   14709540.
• Muntau AC, Roscher AA, Kunau WH, Dodt G (2003). "Interaction of PEX3 and PEX19 Visualized by Fluorescence Resonance Energy Transfer (FRET)". Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology. Vol. 544. pp. 221–4. doi:10.1007/978-1-4419-9072-3_27. ISBN   978-1-4613-4782-8. PMID   14713233.
• Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". J. Biol. Chem. 279 (13): 12615–24. doi: 10.1074/jbc.M304941200 . PMID   14715663.
• Fang Y, Morrell JC, Jones JM, Gould SJ (2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins". J. Cell Biol. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMC   2172291 . PMID   15007061.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Shibata H, Kashiwayama Y, Imanaka T, Kato H (2004). "Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins". J. Biol. Chem. 279 (37): 38486–94. doi: 10.1074/jbc.M402204200 . PMID   15252024.

External links

• GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
• OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
• Overview of all the structural information available in the PDB for UniProt : P40855 (Peroxisomal biogenesis factor 19) at the PDBe-KB .