PEX13

PEX13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WXU
Identifiers
Aliases	PEX13 , NALD, PBD11A, PBD11B, ZWS, peroxisomal biogenesis factor 13
External IDs	OMIM: 601789; MGI: 1919379; HomoloGene: 1967; GeneCards: PEX13; OMA:PEX13 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p15 Start 61,017,225 bp [1] End 61,051,990 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm buccal mucosa cell epithelium of nasopharynx germinal epithelium visceral pleura Achilles tendon gonad mucosa of paranasal sinus ventricular zone n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component peroxisome peroxisomal membrane membrane integral component of peroxisomal membrane intracellular membrane-bounded organelle integral component of membrane peroxisomal importomer complex Biological process cerebral cortex cell migration protein transport suckling behavior fatty acid alpha-oxidation microtubule-based peroxisome localization locomotory behavior protein import into peroxisome matrix, docking neuron migration transport protein targeting to peroxisome protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5194 72129 Ensembl ENSG00000162928 ENSMUSG00000020283 UniProt Q92968 Q9D0K1 RefSeq (mRNA) NM_002618 NM_023651 RefSeq (protein) NP_002609 NP_076140 Location (UCSC) Chr 2: 61.02 – 61.05 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. ^{[4] [5]} It located on chromosome 2 next to KIAA1841

Interactions

PEX13 has been shown to interact with PEX14, ^[6] PEX5 ^{[6] [7]} and PEX19. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000162928 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Björkman J, Stetten G, Moore CS, Gould SJ, Crane DI (December 1998). "Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene". Genomics. 54 (3): 521–8. doi: 10.1006/geno.1998.5520 . PMID   9878256.
5. "Entrez Gene: PEX13 peroxisome biogenesis factor 13".
6. Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC   135613 . PMID   11865044.
7. Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC   2121023 . PMID   8858165.
8. Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC   2174547 . PMID   10704444.
9. Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC   87101 . PMID   11390669.

Further reading

• Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC   2121023 . PMID   8858165.
• Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, Kunau WH (April 1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways" (PDF). Cell. 89 (1): 83–92. doi:10.1016/S0092-8674(00)80185-3. PMID   9094717. S2CID   18878596.
• Fransen M, Terlecky SR, Subramani S (July 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8087–92. Bibcode:1998PNAS...95.8087F. doi: 10.1073/pnas.95.14.8087 . PMC   20933 . PMID   9653144.
• Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R (March 1999). "Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes". The Journal of Cell Biology. 144 (6): 1151–62. doi:10.1083/jcb.144.6.1151. PMC   2150583 . PMID   10087260.
• Shimozawa N, Suzuki Y, Zhang Z, Imamura A, Toyama R, Mukai S, et al. (June 1999). "Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders". Human Molecular Genetics. 8 (6): 1077–83. doi: 10.1093/hmg/8.6.1077 . PMID   10332040.
• Toyama R, Mukai S, Itagaki A, Tamura S, Shimozawa N, Suzuki Y, et al. (September 1999). "Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants". Human Molecular Genetics. 8 (9): 1673–81. doi: 10.1093/hmg/8.9.1673 . PMID   10441330.
• Liu Y, Björkman J, Urquhart A, Wanders RJ, Crane DI, Gould SJ (September 1999). "PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders". American Journal of Human Genetics. 65 (3): 621–34. doi:10.1086/302534. PMC   1377968 . PMID   10441568.
• Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC   2174547 . PMID   10704444.
• Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC   87101 . PMID   11390669.
• Jones JM, Morrell JC, Gould SJ (June 2001). "Multiple distinct targeting signals in integral peroxisomal membrane proteins". The Journal of Cell Biology. 153 (6): 1141–50. doi:10.1083/jcb.153.6.1141. PMC   2192020 . PMID   11402059.
• Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC   135613 . PMID   11865044.
• Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (March 2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Molecular & Cellular Proteomics. 1 (3): 243–52. doi: 10.1074/mcp.M100025-MCP200 . PMID   12096124.
• Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (March 2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". The Journal of Biological Chemistry. 279 (13): 12615–24. doi: 10.1074/jbc.M304941200 . PMID   14715663.
• Hashimoto K, Kato Z, Nagase T, Shimozawa N, Kuwata K, Omoya K, et al. (August 2005). "Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder". Pediatric Research. 58 (2): 263–9. doi: 10.1203/01.PDR.0000169984.89199.69 . PMID   16006427.
• Nguyen T, Bjorkman J, Paton BC, Crane DI (February 2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance". Journal of Cell Science. 119 (Pt 4): 636–45. doi: 10.1242/jcs.02776 . hdl: 2440/23242 . PMID   16449325.

External links

• GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
• OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum