POLR2G

Last updated

POLR2G
Protein POLR2G PDB 2c35.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLR2G , RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G
External IDs OMIM: 602013; MGI: 1914960; HomoloGene: 2019; GeneCards: POLR2G; OMA:POLR2G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002696

NM_026329

RefSeq (protein)

NP_002687

NP_080605

Location (UCSC) Chr 11: 62.76 – 62.77 Mb Chr 19: 8.77 – 8.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene. [5] [6]

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function. [7]

Interactions

POLR2G has been shown to interact with TAF15, [8] POLR2C, [9] POLR2H [9] and POLR2E. [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168002 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071662 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). "Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology". Mol Biol Cell. 6 (7): 759–75. doi:10.1091/mbc.6.7.759. PMC   301239 . PMID   7579693.
  6. Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). "Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization". Biochim Biophys Acta. 1353 (1): 39–49. doi:10.1016/s0167-4781(97)00041-9. PMID   9256063.
  7. "Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G".
  8. Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. 18 (3). UNITED STATES: 1489–97. doi:10.1128/mcb.18.3.1489. ISSN   0270-7306. PMC   108863 . PMID   9488465.
  9. 1 2 3 Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27). UNITED STATES: 16815–21. doi: 10.1074/jbc.272.27.16815 . ISSN   0021-9258. PMID   9201987.

Further reading