POLR2H

POLR2H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F3I, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2H , RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H
External IDs	OMIM: 606023 MGI: 2384309 HomoloGene: 4540 GeneCards: POLR2H
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q27.1 Start 184,361,718 bp [1] End 184,368,596 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B1 Start 20,536,415 bp [2] End 20,541,017 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right lobe of thyroid gland right uterine tube left lobe of thyroid gland right adrenal gland rectum canal of the cervix body of stomach anterior pituitary body of pancreas Top expressed in morula neural tube yolk sac ganglionic eminence ileum bone marrow placenta mesencephalon duodenum adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity single-stranded DNA binding Cellular component nucleolus RNA polymerase II, core complex nucleoplasm cytosol nucleus RNA polymerase III complex RNA polymerase I complex protein-DNA complex Biological process 7-methylguanosine mRNA capping transcription elongation from RNA polymerase II promoter transcription initiation from RNA polymerase I promoter mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation transcription-coupled nucleotide-excision repair termination of RNA polymerase I transcription transcription initiation from RNA polymerase II promoter transcription by RNA polymerase II snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway transcription by RNA polymerase III RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5437 245841 Ensembl ENSG00000163882 ENSMUSG00000021018 UniProt P52434 Q923G2 RefSeq (mRNA) NM_001278698 NM_001278699 NM_001278700 NM_001278714 NM_001278715 NM_006232 NM_001346879 NM_145632 NM_001356423 RefSeq (protein) NP_001265627 NP_001265628 NP_001265629 NP_001265643 NP_001265644 NP_001333808 NP_006223 NP_663607 NP_001343352 Location (UCSC) Chr 3: 184.36 – 184.37 Mb Chr 16: 20.54 – 20.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.

This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. ^[5]

Interactions

POLR2H has been shown to interact with POLR2C, ^[6] POLR2G, ^[6] POLR2A, ^[6] POLR2B ^[6] and POLR2E. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000163882 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021018 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: POLR2H polymerase (RNA) II (DNA directed) polypeptide H".
6. Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27). UNITED STATES: 16815–21. doi: 10.1074/jbc.272.27.16815 . ISSN   0021-9258. PMID   9201987.

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID   9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. Bibcode:1998CBio....8.R447Y. doi: 10.1016/S0960-9822(98)70289-1 . PMID   9651670. S2CID   15480646.
• Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID   10536359. S2CID   43685090.
• Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi: 10.1080/152165401753544241 . PMID   11547919. S2CID   10931640.
• Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMC   7168390 . PMID   16838299.
• Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID   17168834.
• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID   1403646.
• Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi: 10.1101/gad.6.4.655 . PMID   1559613.
• Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID   2190099. S2CID   4233742.
• Freund E, McGuire PM (1986). "Characterization of RNA polymerase type II from human term placenta". J. Cell. Physiol. 127 (3): 432–8. doi:10.1002/jcp.1041270312. PMID   3754875. S2CID   11708971.
• Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi: 10.1073/pnas.92.16.7153 . PMC   41297 . PMID   7638159.
• Shpakovski GV, Acker J, Wintzerith M, et al. (1995). "Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae". Mol. Cell. Biol. 15 (9): 4702–10. doi:10.1128/mcb.15.9.4702. PMC   230713 . PMID   7651387.
• Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–20. doi:10.1128/JVI.69.3.1612-1620.1995. PMC   188757 . PMID   7853496.
• McKune K, Moore PA, Hull MW, Woychik NA (1996). "Six human RNA polymerase subunits functionally substitute for their yeast counterparts". Mol. Cell. Biol. 15 (12): 6895–900. doi:10.1128/mcb.15.12.6895. PMC   230944 . PMID   8524256.
• Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. doi: 10.1073/pnas.93.6.2505 . PMC   39827 . PMID   8637904.
• Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–84. doi:10.1128/JVI.70.7.4576-4584.1996. PMC   190394 . PMID   8676484.
• Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID   8800208.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID   8849451. S2CID   13266489.
• Okamoto H, Sheline CT, Corden JL, et al. (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. doi: 10.1073/pnas.93.21.11575 . PMC   38099 . PMID   8876177.
• Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". J. Biol. Chem. 271 (44): 27888–94. doi: 10.1074/jbc.271.44.27888 . PMID   8910388.