PPP1R11

PPP1R11
Identifiers
Aliases	PPP1R11 , HCG-V, HCGV, IPP3, TCTE5, TCTEX5, CFAP255, protein phosphatase 1 regulatory inhibitor subunit 11
External IDs	OMIM: 606670 MGI: 1923747 HomoloGene: 32520 GeneCards: PPP1R11
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 30,066,709 bp [1] End 30,070,333 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 19.16 cM Start 37,259,248 bp [2] End 37,262,633 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum superior frontal gyrus smooth muscle tissue duodenum blood body of stomach dorsolateral prefrontal cortex gallbladder hypothalamus fundus Top expressed in seminiferous tubule spermatid spermatocyte interventricular septum yolk sac superior frontal gyrus lateral hypothalamus ventromedial nucleus neural tube cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity protein binding protein phosphatase 1 binding protein serine/threonine phosphatase inhibitor activity ubiquitin protein ligase activity transferase activity Cellular component cytoplasm protein phosphatase type 1 complex nucleus Biological process negative regulation of phosphoprotein phosphatase activity defense response to Gram-positive bacterium protein ubiquitination ubiquitin-dependent protein catabolic process negative regulation of protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6992 76497 Ensembl ENSG00000234058 ENSG00000236560 ENSG00000237829 ENSG00000204619 ENSG00000237403 ENSG00000233314 ENSG00000206501 ENSG00000227720 ENSMUSG00000036398 UniProt O60927 Q8K1L5 RefSeq (mRNA) NM_021959 NM_170781 NM_029632 RefSeq (protein) NP_068778 NP_068778.1 NP_083908 Location (UCSC) Chr 6: 30.07 – 30.07 Mb Chr 17: 37.26 – 37.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene. ^{[5] [6] [7]}

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1.

The gene is located within the major histocompatibility complex class I region on chromosome 6. ^[7]

References

1. ENSG00000236560, ENSG00000237829, ENSG00000204619, ENSG00000237403, ENSG00000233314, ENSG00000206501, ENSG00000227720 GRCh38: Ensembl release 89: ENSG00000234058, ENSG00000236560, ENSG00000237829, ENSG00000204619, ENSG00000237403, ENSG00000233314, ENSG00000206501, ENSG00000227720 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036398 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang J, Zhang L, Zhao S, Lee EY (Dec 1998). "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1". Biochemistry. 37 (47): 16728–34. doi:10.1021/bi981169g. PMID   9843442.
6. Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V (Oct 1996). "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region". Immunogenetics. 44 (5): 331–9. doi:10.1007/BF02602777. PMID   8781118. S2CID   7130465.
7. "Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11".

Further reading

• Amadou C, Ribouchon MT, Mattei MG, et al. (1995). "Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes". Genomics. 26 (1): 9–20. doi:10.1016/0888-7543(95)80077-Y. PMID   7782091.
• el Kahloun A, Chauvel B, Mauvieux V, et al. (1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55–60. doi:10.1093/hmg/2.1.55. PMID   8490624.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Lepourcelet M, Andrieux N, Giffon T, et al. (1997). "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence". Genomics. 37 (3): 316–26. doi:10.1006/geno.1996.0566. PMID   8938444.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry. 46 (31): 8909–19. doi:10.1021/bi7003119. PMID   17630778.