PSRC1

PSRC1
Identifiers
Aliases	PSRC1 , DDA3, FP3214, proline and serine rich coiled-coil 1
External IDs	OMIM: 613126 MGI: 1913099 HomoloGene: 49603 GeneCards: PSRC1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 109,279,556 bp [1] End 109,283,186 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F3 Start 108,291,155 bp [2] End 108,295,547 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus inferior ganglion of vagus nerve hippocampus proper Brodmann area 9 substantia nigra ganglionic eminence amygdala corpus callosum prefrontal cortex middle temporal gyrus Top expressed in secondary oocyte condyle calvaria maxillary prominence abdominal wall medial ganglionic eminence lip hair follicle blastocyst morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding microtubule binding Cellular component spindle microtubule cytoskeleton spindle cytosol microtubule cytoskeleton spindle pole midbody cytoplasm nucleoplasm Biological process mitotic metaphase plate congression negative regulation of cell growth microtubule bundle formation regulation of mitotic spindle organization cell division cell cycle cellular process positive regulation of transcription, DNA-templated positive regulation of microtubule polymerization positive regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84722 56742 Ensembl ENSG00000134222 ENSMUSG00000068744 UniProt Q6PGN9 Q5T2Z0 Q9D0P7 RefSeq (mRNA) NM_001005290 NM_001032290 NM_001032291 NM_032636 NM_001350237 NM_001350238 NM_001350239 NM_001350240 NM_001350241 NM_001350242 NM_001363309 NM_001394002 NM_001394003 NM_001394004 NM_001394005 NM_001190161 NM_019976 RefSeq (protein) NP_001005290 NP_001027462 NP_116025 NP_001337166 NP_001337167 NP_001337168 NP_001337169 NP_001337170 NP_001337171 NP_001350238 NP_001177090 NP_064360 Location (UCSC) Chr 1: 109.28 – 109.28 Mb Chr 3: 108.29 – 108.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proline/serine-rich coiled-coil protein 1 is a protein that in humans is encoded by the PSRC1 gene. ^{[5] [6] [7]}

This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000134222 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068744 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2–3): 214–8. doi:10.1016/s0167-4781(02)00512-2. PMID   12427559.
6. Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". Oncogene. 18 (54): 7765–74. doi: 10.1038/sj.onc.1203167 . PMID   10618717.
7. "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1".

Further reading

• Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC   2682493 . PMID   18193044.
• Wallace C, Newhouse SJ, Braund P, et al. (2008). "Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia". Am. J. Hum. Genet. 82 (1): 139–49. doi:10.1016/j.ajhg.2007.11.001. PMC   2253977 . PMID   18179892.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.