PURB

PURB
Identifiers
Aliases	PURB , PURBETA, purine-rich element binding protein B, purine rich element binding protein B
External IDs	OMIM: 608887 MGI: 1338779 HomoloGene: 69087 GeneCards: PURB
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,885,530 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,425,917 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pancreatic epithelial cell; ; pancreatic ductal cell; ; visceral pleura; ; Brodmann area 23; ; tibialis anterior muscle; ; vulva; ; middle temporal gyrus; ; saphenous vein; ; parietal pleura;
	Top expressed in
	Region I of hippocampus proper; ; primary motor cortex; ; piriform cortex; ; olfactory tubercle; ; cingulate gyrus; ; superior colliculus; ; lateral geniculate nucleus; ; subiculum; ; nucleus accumbens; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; DNA binding ; double-stranded DNA binding ; SMAD binding ; single-stranded DNA binding ; transcription factor binding ; mRNA binding ; RNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ; purine-rich negative regulatory element binding ; sequence-specific DNA binding ;
Cellular component	DNA replication factor A complex ; nucleus ;
Biological process	regulation of myeloid cell differentiation ; regulation of transcription, DNA-templated ; negative regulation of transcription by RNA polymerase II ; cell population proliferation ; cell differentiation ; transcription, DNA-templated ; negative regulation of transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	5814
	19291
	ENSG00000146676
	ENSMUSG00000094483
	Q96QR8
	O35295
	NM_033224
	NM_011221
	NP_150093
	NP_035351
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 28, 2024

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.^[5]^[6]

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.

Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146676 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000094483 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bergemann AD, Ma ZW, Johnson EM (Dec 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Mol Cell Biol. 12 (12): 5673–82. doi:10.1128/mcb.12.12.5673. PMC 360507 . PMID 1448097.
1 2 "Entrez Gene: PURB purine-rich element binding protein B".

Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Kelm RJ, Cogan JG, Elder PK, Strauch AR, Getz MJ (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi: 10.1074/jbc.274.20.14238 . PMID 10318844.
Lezon-Geyda K, Najfeld V, Johnson EM (2001). "Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia". Leukemia. 15 (6): 954–62. doi:10.1038/sj.leu.2402108. PMID 11417483. S2CID 7186291.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-Mcpherson C, Layman D, Maas J, Jaeger S (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Gupta M, Sueblinvong V, Raman J, Jeevanandam V, Gupta MP (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi: 10.1074/jbc.M307696200 . PMID 12933792.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146676 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000094483 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1448097-5] Bergemann AD, Ma ZW, Johnson EM (Dec 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Mol Cell Biol. 12 (12): 5673–82. doi:10.1128/mcb.12.12.5673. PMC 360507 . PMID 1448097.

[entrez-6] 1 2 "Entrez Gene: PURB purine-rich element binding protein B".

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PURB

Related Research Articles

References

Further reading