| Penicillium sizovae | |
|---|---|
Scientific classification  | |
| Domain: | Eukaryota |
| Kingdom: | Fungi |
| Division: | Ascomycota |
| Class: | Eurotiomycetes |
| Order: | Eurotiales |
| Family: | Aspergillaceae |
| Genus: | Penicillium |
| Species: | P. sizovae |
| Binomial name | |
| Penicillium sizovae Baghd. 1968 [1] | |
| Type strain | |
| ATCC 48712, CBS 413.69, FRR 0518, IMI 140344, VKM F-1073 [2] | |
Penicillium sizovae is an anamorph species of fungus in the genus Penicillium which produces agroclavine-I and epoxyagroclavine-I. [1] [3] [4] [5]
Penicillium is a genus of ascomycetous fungi that is part of the mycobiome of many species and is of major importance in the natural environment, in food spoilage, and in food and drug production.
Ergot or ergot fungi refers to a group of fungi of the genus Claviceps.
Ergotism is the effect of long-term ergot poisoning, traditionally due to the ingestion of the alkaloids produced by the Claviceps purpurea fungus—from the Latin clava "club" or clavus "nail" and -ceps for "head", i.e. the purple club-headed fungus—that infects rye and other cereals, and more recently by the action of a number of ergoline-based drugs. It is also known as ergotoxicosis, ergot poisoning, and Saint Anthony's fire.
Lysergic acid, also known as D-lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of Turbina corymbosa (ololiuhqui), Argyreia nervosa, and Ipomoea tricolor.
Methylergometrine, also known as methylergonovine and sold under the brand name Methergine, is a medication of the ergoline and lysergamide groups which is used as an oxytocic in obstetrics and in the treatment of migraine. It reportedly produces psychedelic effects similar to those of lysergic acid diethylamide (LSD) at high doses.
A sclerotium, is a compact mass of hardened fungal mycelium containing food reserves. One role of sclerotia is to survive environmental extremes. In some higher fungi such as ergot, sclerotia become detached and remain dormant until favorable growth conditions return. Sclerotia initially were mistaken for individual organisms and described as separate species until Louis René Tulasne proved in 1853 that sclerotia are only a stage in the life cycle of some fungi. Further investigation showed that this stage appears in many fungi belonging to many diverse groups. Sclerotia are important in the understanding of the life cycle and reproduction of fungi, as a food source, as medicine, and in agricultural blight management.
Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine. The amino acid tryptophan is the biochemical precursor of indole alkaloids.
Claviceps purpurea is an ergot fungus that grows on the ears of rye and related cereal and forage plants. Consumption of grains or seeds contaminated with the survival structure of this fungus, the ergot sclerotium, can cause ergotism in humans and other mammals. C. purpurea most commonly affects outcrossing species such as rye, as well as triticale, wheat and barley. It affects oats only rarely.
Claviceps sorghi is a fungal plant pathogen belonging to the phylum Ascomycota in the kingdom Fungi- its anamorphic phase is known as sphacelia sorghi. This species was first found in In India in 1915 and officially recorded in 1948 . The Claviceps genus is known for their infection of cereal and millet crops. This particular species of Claviceps infects Sorghum- giving the fungus its name 'sorghi'. These species in Claviceps are known to produce ergot on their host, as a byproduct of their infection. This can cause the disease known as ergotism when the infected crop is consumed.
Ipomoea hederacea, the ivy-leaved morning glory or Kaladana, is a flowering plant in the bindweed family. The species is native to tropical parts of the Americas, and has more recently been introduced to North America. It now occurs there from Arizona to Florida and north to Ontario and North Dakota. Like most members of the family, it is a climbing vine with alternate leaves on twining stems. The flowers are blue to rose-purple with a white inner throat and emerge in summer and continue until late fall. The leaves are typically three-lobed, but sometimes may be five-lobed or entire. Flowers occur in clusters of one to three and are 2.5–4.5 cm long and wide. The sepals taper to long, recurved tips and measure 12–24 mm long. The species shares some features with the close relative Ipomoea purpurea, and is almost identical in appearance to wild forms of I. nil.
Ergocryptine is an ergopeptine and one of the ergoline alkaloids. It is isolated from ergot or fermentation broth and it serves as starting material for the production of bromocriptine. Two isomers of ergocryptine exist, α-ergocryptine and β-ergocryptine. The beta differs from the alpha form only in the position of a single methyl group, which is a consequence of the biosynthesis in which the proteinogenic amino acid leucine is replaced by isoleucine. β-Ergocryptine was first identified in 1967 by Albert Hofmann. Ergot from different sources have different ratios of the two isomers.
Balansia is a genus of fungi in the family Clavicipitaceae.
Secalonic acids are a group of xanthone derivatives closely related to ergoflavin and ergochrysin A that are collectively called ergochromes and belong to a class of mycotoxins initially isolated as major ergot pigments from the fungi Claviceps purpurea that grows parasitically on rye grasses. From early times and particularly in medieval Europe the consumption of grains containing ergot has repeatedly lead to mass poisonings known as ergotism which was caused by toxic ergot alkaloids and mycotoxins such as the ergochromes, due to contamination of flour by C. purpurea. A cluster of genes responsible for the synthesis of secalonic acids in C. purpurea has been identified. Secalonic acid D the enantiomer of secalonic acid A is a major environmental toxin, isolated from the fungus Penicillium oxalicum, and is a major microbial contaminant of freshly-harvested corn which causes toxicity through contamination of foodstuffs.
Medicinal fungi are fungi that contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs. Compounds successfully developed into drugs or under research include antibiotics, anti-cancer drugs, cholesterol and ergosterol synthesis inhibitors, psychotropic drugs, immunosuppressants and fungicides.
Penicillium gorlenkoanum is a species of the genus of Penicillium which produces citrinin, costaclavine and epicostaclavine.
Penicillium novae-zelandiae is an anamorph species of fungus in the genus Penicillium which was isolated from the plant Festuca novae-zelandiae. Penicillium novae-zelandiae produces patulin, 3-hydroxybenzyl alcohol and gentisyl alcohol
Penicillium simplicissimum is an anamorph species of fungus in the genus Penicillium which can promote plant growth. This species occurs on food and its primary habitat is in decaying vegetations Penicillium simplicissimum produces verruculogene, fumitremorgene B, penicillic acid, viridicatumtoxin, decarestrictine G, decarestrictine L, decarestrictine H, decarestrictine I, decarestrictine K decarestrictine M, dihydrovermistatin, vermistatin and penisimplicissin
Penicillium steckii is a species of fungus in the genus Penicillium which produces citrinin, tanzawaic acid E, tanzawaic acid F.
Penicillium thomii is an anamorph species of fungus in the genus Penicillium which was isolated from spoiled faba beans in Australia. Penicillium thomii produces hadicidine, 6-methoxymelline and penicillic acid
Penicillium tricolor is a species of fungus in the genus Penicillium which was isolated from wheat in Canada. Penicillium tricolor produces xanthomegnin, viomellein, vioxanthin, terrestric acid, rugulosuvine, verrucofortine, puberuline, asteltoxin