A mycotoxin is a toxic secondary metabolite produced by fungi and is capable of causing disease and death in both humans and other animals. The term 'mycotoxin' is usually reserved for the toxic chemical products produced by fungi that readily colonize crops.
Griseofulvin is an antifungal medication used to treat a number of types of dermatophytoses (ringworm). This includes fungal infections of the nails and scalp, as well as the skin when antifungal creams have not worked. It is taken by mouth.
In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups: [−C(=O)−CH2−]n. First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity.
Penicillium roqueforti is a common saprotrophic fungus in the genus Penicillium. Widespread in nature, it can be isolated from soil, decaying organic matter, and plants.
Coniella fragariae is a plant pathogen. It is known to be pathogenic on eucalypts in a number of countries, including Brazil, India, China and Australia. In 2015, Coniella fragariae was reported as the causal agent for strawberry crown rot in Latvia. In 2018, the fungus was isolated from a goose dung collected in a strawberry field near the sea coast in North Germany. Inferred from the author, it should be a typical plant pathogenic fungus not coprophilous fungus. The plants, strawberry that had been eaten by geese are expected to be the true source of Coniella fragariae. Chemical constitution study showed azaphilone were the main secondary metabolites from this fungus.
Brevianamides are indole alkaloids that belong to a class of naturally occurring 2,5-diketopiperazines produced as secondary metabolites of fungi in the genus Penicillium and Aspergillus. Structurally similar to paraherquamides, they are a small class compounds that contain a bicyclo[2.2.2]diazoctane ring system. One of the major secondary metabolites in Penicillium spores, they are responsible for inflammatory response in lung cells.
Chaetomium cupreum is a fungus in the family Chaetomiaceae. It is able to decay in manufactured cellulosic materials, and is known to antagonize a wide range of soil microorganisms. This species is component of the biocontrol agent, Ketomium, a commercial biofungicide. It has also been investigated for use in the production of natural dyes. Chaetomium cupreum is mesophilic and known to occur in harsh environments and can rapidly colonize organic substrates in soil. Laboratory cultures of C. cupreum can be propagated on a range of common growth media including potato dextrose at ambient or higher than ambient temperature producing cottony white colonies with a reddish reverse.
2,4-Diacetylphloroglucinol or Phl is a natural phenol found in several bacteria:
Citromycin is a chemical compound produced by Penicillium. It was first discovered in 1969 and was found to have weak antibiotic activity.
Citromycetin is a bio-active polyketide isolated from Australian Penicillium.
Phoriospongin A and B are Australian sea sponge isolates with nematocidal activity. They are depsipeptides and were obtained from Phoriospongia species and Callyspongia bilamellata.
Fungal isolates have been researched for decades. Because fungi often exist in thin mycelial monolayers, with no protective shell, immune system, and limited mobility, they have developed the ability to synthesize a variety of unusual compounds for survival. Researchers have discovered fungal isolates with anticancer, antimicrobial, immunomodulatory, and other bio-active properties. The first statins, β-Lactam antibiotics, as well as a few important antifungals, were discovered in fungi.
Penicillium hordei is a species of the genus of Penicillium which produces corymbiferone and roquefortine C.
Penicillium nalgiovense is an anamorph species of the genus Penicillium with lipolytic and proteolytic activity, which was first isolated from ellischau cheese. This species produces dichlorodiaportin, diaportinol, and diaportinic acid Penicillium nalgiovense is used for the maturation of certain fermented salami varieties and ham. In this process it protects the meat from colonization by other molds and bacteria
Penicillium oxalicum is an anamorph species of the genus Penicillium which was isolated from rhizosphere soil of pearl millet. Penicillium oxalicum produces secalonic acid D, chitinase, oxalic acid, oxaline and β-N-acetylglucosaminidase and occurs widespread in food and tropical commodities. This fungus could be used against soilborne diseases like downy mildew of tomatoes
Penicillium restrictum is a species of fungus in the genus Penicillium which was isolated from the stems of the plant Silybum marianum. Penicillium restrictum produces calbistrin A
Penicillium simplicissimum is an anamorph species of fungus in the genus Penicillium which can promote plant growth. This species occurs on food and its primary habitat is in decaying vegetations Penicillium simplicissimum produces verruculogene, fumitremorgene B, penicillic acid, viridicatumtoxin, decarestrictine G, decarestrictine L, decarestrictine H, decarestrictine I, decarestrictine K decarestrictine M, dihydrovermistatin, vermistatin and penisimplicissin
Streptomyces canus is a bacterium species from the genus of Streptomyces which has been isolated from soil in the US. Streptomyces canus produces resistomycin, tetracenomycin D, amphomycin, aspartocin D and aspartocin E.
Streptomyces lydicus is a bacterium species from the genus of Streptomyces which has been isolated from soil in the United States. Streptomyces lydicus produces actithiazic acid, natamycin, lydimycin, streptolydigin, and 1-deoxygalactonojirimycin. Streptomyces lydicus can be used as an agent against fungal plant pathogens like Fusarium, Pythium, Phytophthora, Rhizoctonia and Verticillum.
Griseoxanthone C is an organic compound in the structural class of chemicals known as xanthones. Its chemical formula is 1,6-dihydroxy-3-methoxy-8-methylxanthen-9-one, and its molecular formula is C15H12O5. It is found in a plant and some fungi, including a lichen.
