In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups: [−C(=O)−CH2−]n. First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity.
Penicillium griseofulvum is a species of the genus of Penicillium which produces patulin, penifulvin A, cyclopiazonic acid, roquefortine C, shikimic acid, griseofulvin, and 6-Methylsalicylic acid. Penicillium griseofulvum occurs on cereals and nuts.
Riccardin C is a macrocyclic bis(bibenzyl). It is a secondary metabolite isolated from the Siberian cowslip subspecies Primula veris subsp. macrocalyx, in Reboulia hemisphaerica and in the Chinese liverwort Plagiochasma intermedium.
Verruculogen is a mycotoxin produced by certain strains of aspergillus that belongs to a class of naturally occurring 2,5-diketopiperazines. It is an annulated analogue of cyclo(L-Trp-L-Pro) which belongs to the most abundant and structurally diverse class of tryptophan-proline 2,5-diketopiperazine natural products. It produces tremors in mice due to its neurotoxic properties. It also tested positive in a Salmonella/mammalian microsome assay and was shown to be genotoxic. It is a potent blocker of calcium-activated potassium channels.
Penicillium decumbens is an anamorph species of the genus of Penicillium which occurs widespread in nature, mainly in subtropical and tropical soil but it also occur in food. Analysis have shown that Penicillium decumbens has antibiotic activity Penicillium decumbens produces the cyclopentenone cyclopenicillone
Penicillium islandicum is an anamorph species of the genus of Penicillium which produces luteoskyrin, simatoxin, cyclochlorotine, rugulosin, islanditoxin and chitosanase.
Penicillium jensenii is an anamorph species of the genus of Penicillium which produces citrinin, griseofulvin and fumagillin.
Penicillium occitanis is a species of fungus in the genus Penicillium which produces cellulase and pectinase. The mutant Pol6 produces a very high amount of cellulase and pectinase. This mutant might be used for industrial use.
Penicillium pinophilum is a species of fungus in the genus Penicillium which was isolated from a radio set in Papua New Guinea. Penicillium pinophilum produces 3-O-methylfunicone and mycophenolic acid
Penicillium raistrickii is an anamorph species of fungus in the genus Penicillium which produces griseofulvin, patulin and verruculogen.
Penicillium roseopurpureum is an anamorph species of fungus in the genus Penicillium which produces Carviolin.
Penicillium rubrum is a species of fungus in the genus Penicillium which produces kojic acid, mitorubrin, mitorubrinol, rubratoxin A, rubratoxin B rubralactone, rubramin and occurs in grain corn and soybeans. Penicillium rubrum is similar to the species Penicillium chrysogenum.
The Römpp Encyclopedia Natural Products is an encyclopedia of natural products written by German chemists who specialize in this area of science. It is published by Thieme Medical Publishers.
Penicillium simplicissimum is an anamorph species of fungus in the genus Penicillium which can promote plant growth. This species occurs on food and its primary habitat is in decaying vegetations Penicillium simplicissimum produces verruculogene, fumitremorgene B, penicillic acid, viridicatumtoxin, decarestrictine G, decarestrictine L, decarestrictine H, decarestrictine I, decarestrictine K decarestrictine M, dihydrovermistatin, vermistatin and penisimplicissin
Penicillium velutinum is an anamorph species of fungus in the genus Penicillium which produces citrinin. Penicillium velutinum can spoil fruit juices.
Penicillium viridicatum is a psychrophilic species of fungus in the genus, penicillic acid and citrinin. Penicillium viridicatum can spoil grapes and melons.
Streptomyces diastatochromogenes is a bacterium species from the genus of Streptomyces. Streptomyces diastatochromogenes produces polyketomycin, concanamycin A, concanamycin B, concanamycin C, momofulvenone A, azdimycin, toyocamycin and oligomycins.
Streptomyces flaveolus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces flaveolus produces L-isoleucine, actinomycin J and tirandamycin.
Aspergillus luppii is a species of fungus in the genus Aspergillus. It is from the Flavipedes section. Aspergillus luppii produces the antimicrobics Curvularin and Dehydrocurvularin.
Luteoskyrin is a carcinogenic mycotoxin with the molecular formula C30H22O12 which is produced by the mold Penicillium islandicum. Luteoskyrin has strong cytotoxic effects. Luteoskyrin can cause the yellow rice disease.
