Pennsylvania Route 26 is a 125.5-mile (202.0 km) highway in the south-central area of Pennsylvania. Its northern terminus is at PA 150 northwest of Howard; its southern terminus is at the Maryland state line near Barnes Gap in Union Township. Two major destinations along this route are Raystown Lake near Huntingdon and the Pennsylvania State University at State College.
Pennsylvania Route 49 is a 52.6-mile-long (84.7 km) state highway located in northern Pennsylvania. The western terminus of the route is at PA 44 three miles north of Coudersport. The eastern terminus is at PA 287 in Lawrenceville less than 300 yards (270 m) south of the New York border. PA 49 serves as North Street, North Main Street, and Northern Potter Road in Ulysses, as Cowanesque Street in Lawrenceville, and as both East and West Main Street for Harrison Valley, Westfield, Knoxville, and Elkland. It is concurrent with PA 249 for 2.5 miles (4.0 km) between Cowanesque and Knoxville.
Pennsylvania Route 53 is an 83-mile-long (134 km) state highway located in central Pennsylvania. The southern terminus of the route is at U.S. Route 219 (US 219) near the borough of Summerhill. The northern terminus is at PA 144 in the Snow Shoe Township community of Moshannon.
Pennsylvania Route 74 is a 96.4-mile-long (155.1 km) north–south state highway located in central Pennsylvania. The southern terminus of the route is at the Mason–Dixon line southwest of Delta, where PA 74 continues into Maryland as Maryland Route 165. The northern terminus is at PA 75 south of Port Royal.
Pennsylvania Route 75 is a 71.2-mile-long (114.6 km) north–south state highway located in central Pennsylvania. The southern terminus is at the Mason–Dixon line in Montgomery Township, where the road continues into Maryland as Maryland Route 494. The northern terminus is at an interchange with U.S. Route 22 and US 322 northeast of Port Royal. PA 75 is a two-lane undivided road that passes through the Ridge-and-Valley Appalachians in Franklin and Juniata counties. The route heads north from the Maryland border in Franklin County to Mercersburg, where it runs concurrent with PA 16 and PA 416. From Mercersburg, PA 75 heads north and crosses US 30 in Fort Loudon before it runs northeast through a long valley, where it has an interchange with the Pennsylvania Turnpike in Willow Hill. The route turns north and heads into Juniata County, where it continues through another valley. PA 75 passes through Port Royal and crosses the Juniata River before it comes to its terminus at US 22/US 322.
Pennsylvania Route 87 is a 69.3-mile-long (111.5 km) north–south state highway located in northern Pennsylvania. The southern terminus of the route is at exit 21 of Interstate 180 (I-180)/U.S. Route 220 in Montoursville. The northern terminus is at US 6 in Washington Township.
Pennsylvania Route 94 is a 30-mile (48 km) long north–south state highway located in southern Pennsylvania. The southern terminus of the route is at the Mason–Dixon line, where PA 94 continues into Maryland as Maryland Route 30. The northern terminus is at PA 34 south of Mount Holly Springs. PA 94 heads north-northwest from the state line through southwestern York County, where it passes through Hanover and intersects PA 116/PA 194 in the center of town. Past Hanover, the route heads into rural areas and crosses into the eastern portion of Adams County. Here, PA 94 intersects U.S. Route 30 east of New Oxford, PA 394 in Hampton, PA 234 north of Hampton, and US 15 in York Springs. The route heads into Cumberland County and crosses South Mountain, reaching its end at PA 34. PA 94 is designated as the 94th Infantry Division Memorial Highway for its entire length.
Pennsylvania Route 655 is an 83-mile-long (134 km) north–south state highway located in central Pennsylvania. The southern terminus of the route is at the Mason–Dixon line in Thompson Township, where the road becomes a local road in Hancock, Maryland. The northern terminus is at State Route 1005, the former alignment of U.S. Route 322, in Reedsville.
Pennsylvania Route 168 is a highway in Western Pennsylvania that runs for 55 miles (89 km) from PA 18 in Frankfort Springs to PA 208 in Volant. PA 168 intersects or runs concurrently with PA 18 at several points, including New Castle.
Pennsylvania Route 487 is a 64.2-mile-long (103.3 km), north–south state highway running from PA 61 in Shamokin Township, Northumberland County, to PA 87 in Dushore, Sullivan County. In Bloomsburg, PA 487 and US 11 share a brief wrong-way concurrency. After its brief concurrency with PA 118, PA 487 goes up a steep grade through Ricketts Glen State Park. PA 487 is used to carry traffic up the Fishing Creek valley.
Pennsylvania Route 160 (PA 160) is a north–south state highway in Somerset and Cambria counties in western Pennsylvania, United States. Its southern terminus is at the Mason-Dixon line south of Wellersburg, where the road continues into Maryland as Maryland Route 47 (MD 47), and its northern terminus is at West High Street, which is designated State Route 4031 (SR 4031) and is formerly U.S. Route 219 (US 219), in Ebensburg.
Pennsylvania Route 869 is an east–west state route located in Western Pennsylvania. Its western terminus is at Ragers Hill Road just west of U.S. Route 219 in St. Michael, Adams Township, and its eastern terminus is at PA 36 in South Woodbury Township.
Pennsylvania Route 164 is a 36-mile-long (58 km) state highway located in Cambria, Blair, and Bedford counties in Pennsylvania. The western terminus is at an interchange with U.S. Route 22 (US 22) in Munster Township. The eastern terminus is at PA 26 near Raystown Lake.
Pennsylvania Route 281 is a 45.8-mile-long (73.7 km) state highway located in Fayette and Somerset counties in Pennsylvania. The southern terminus is the West Virginia state line near Markleysburg, where the road becomes West Virginia Route 26. The northern terminus is at U.S. Route 30 in Stoystown.
Pennsylvania Route 305 is a 29-mile-long (47 km) state highway located in Huntingdon and Mifflin counties in Pennsylvania. The western terminus is at U.S. Route 22 in Alexandria. The eastern terminus is at PA 655 in Belleville. The route crosses the Stone Mountain ridge following a valley along a fault line at 40°37′46″N77°45′31″W near Greenwood Furnace State Park.
Pennsylvania Route 326 is a 24-mile-long (39 km) state highway located in Bedford County, Pennsylvania. The southern terminus is at the Maryland state line near Flintstone, Maryland. The northern terminus is at U.S. Route 30 east of Bedford.
Pennsylvania Route 333 is a 31-mile-long (50 km) state highway located in Mifflin and Juniata counties in Pennsylvania. The western terminus is at PA 103 in Juniata Terrace. The eastern terminus is at PA 235 near Thompsontown.
Pennsylvania Route 414 is a 79.4-mile-long (127.8 km) state highway located in Lycoming, Tioga, and Bradford Counties in Pennsylvania. The western terminus is at PA 44 in Waterville. The eastern terminus is at US 220 in Monroe. The first leg of the highway, between its intersection with PA 44 in Waterville and Blackwell is very narrow and rugged.
Pennsylvania Route 851 is a 32.6-mile-long (52.5 km) state highway located in York County, Pennsylvania. The western terminus is at PA 516 in the Codorus Township community of Sticks. The eastern terminus is at PA 74 in Peach Bottom Township. PA 851 is a two-lane undivided road that runs through rural areas in southern York County a short distance to the north of the Maryland border. The route heads east from Sticks to New Freedom, where it turns north and intersects PA 616 in Railroad. PA 851 heads east through Shrewsbury and comes to an interchange with Interstate 83 (I-83). From here, the route heads east and passes through Stewartstown, where it forms a short concurrency with PA 24, and Fawn Grove, where it intersects PA 425, before continuing to its terminus. PA 851 has a truck route, PA 851 Truck, which bypasses the stretch between New Freedom and Shrewsbury.
Pennsylvania Route 913 is a 17.7-mile-long (28.5 km) state highway located in Bedford, Huntingdon and Fulton Counties in Pennsylvania. The western terminus is at PA 26 in Saxton. The eastern terminus is at PA 655 in Taylor Township.
MD 35 in Londonderry Township 
PA 869 in Lincoln Township 
