Pneumoviridae

Last updated
Pneumoviridae
Ijms-20-04657-g008.webp
Pneumovirus structure and genome
Respiratory syncytial virus 01.jpg
Transmission electron micrograph of Human orthopneumovirus
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family:Pneumoviridae
Genera [1]

Pneumoviridae (from Greek pneumo- 'lung' + -viridae 'virus', from Latin, 'poison, slimy liquid') [2] [3] is a family of negative-strand RNA viruses in the order Mononegavirales . [1] [4] Humans, cattle, and rodents serve as natural hosts. [5] Respiratory tract infections are associated with member viruses such as human respiratory syncytial virus. There are five species in the family which are divided between the genera Metapneumovirus and Orthopneumovirus . The family used to be considered as a sub-family of Paramyxoviridae , but has been reclassified as of 2016. [1]

Contents

Virology

Structure

Pneumoviruses are pleomorphic, capable of producing spherical and filamentous, enveloped virions (virus particles) that vary in size from 150 to 200 nm in diameter. The nucleocapsid consisting of a protein shell and viral nucleic acids has a helical symmetry. Nucleocapsids have a diameter of 13.5 nm and a helical pitch of 6.5 nm. [6]

Genome

The genome is composed of negative-sense, single-stranded RNA that is non-segmented. It is about 15 kbp in size, and encodes eleven proteins. [5] A unique feature of the genome is the M2 gene, which encodes proteins M2-1 and M2-2. The pneumovirus M2-1 protein is distinctive, and no homologue has been found in any other virus families. It functions as a processivity factor for the virus RNA-dependent RNA polymerase, and promotes viral RNA synthesis. [7] Viruses in this family are often associated with respiratory infections, and are transmitted through respiratory secretions. [5]

Proteins

N – Nucleocapsid protein. Essential for viral replication and transcription. Plays a major role in forming a capsid around the viral genome. [8]

P – Phosphoprotein required for replication. [8] Facilitates RNA-dependent RNA polymerase attachment and recruits M2 protein. [9]

M1 – Matrix protein. Facilitates nucleocapsid and envelope interactions. [10]

M2-1 – Matrix protein. Intragenic and intergenic transcription factor required for mRNA transcript elongation. [8] Binds to nascent and provides stability in order to prevent premature termination. [11]

M2-2 – Matrix protein. Involved in regulating transcription and replication. When over expressed, has been shown to inhibit viral replication. [12]

F – Fusion protein. Type I glycoprotein that facilitates fusion between the virus and the host cell membrane. [13]

SH – Small hydrophobic protein. Non essential. Exact function is unknown. Suggested to alter membrane permeability and block apoptosis. [13] [14]

G – Type II glycoprotein. [13] Facilitates virus attachment through interactions with glycosaminoglycans. [15]

L – RNA dependent RNA polymerase. [16] Required for replication. [8] Adds a methylated guanosine cap and poly(A) tail to nascent mRNA. [16]

Replication

Pneumoviruses replicate in the cytoplasm of the host cell. [1] [5] First, the virus binds to HN glycoprotein receptors expressed on the surface of the cell. [5] Then, through the action of the fusion protein, the virus fuses to the host plasma membrane and the nucleocapsid is released. [5] Prior to undergoing replication, mRNA is transcribed and viral proteins are translated. Transcription is dependent on virally encoded RNA-dependent-RNA-polymerase, which binds the genome at the 3' leader region and then sequentially transcribes each gene. Translation of viral proteins is carried out by host cell ribosomes. [17] [18] Once sufficient P, N, L, and M2 proteins are available to create a capsid around the newly replicated genome, the virus undergoes replication. [18] After replication, the P, L, and M proteins participate in forming the ribonucleocapsid. Once virion assembly is complete, the virion egresses by budding out of the cell. [18]

Infection in humans

Human metapneumovirus (HMPV) was first classified as a pneumovirus in 2001. It is a negative-strand RNA virus that is the second most common cause of lower respiratory infection in young children. Pneumoviruses are intermediate in size between viruses of the families Paramyxoviridae and Orthomyxoviridae . Cytoplasmic inclusions are considerably more dense than those of other viruses in the family. Human metapneumovirus infection is very similar to the common cold; it is an upper respiratory infection. It will typically occur in the winter and early spring. This specific infection is most common in children, especially under the age of five. Common symptoms include runny nose, congestion, sore throat, cough, headache, and fever, which can be seen as a cold. It will typically go away after a few days. If this is seen in people over 75, then there is a cause for concern as it can turn to pneumonia. [19] [20] [21] [22] [23]

Taxonomy

Family Pneumoviridae: genera, species, and their viruses [1] [24]
GenusSpeciesVirus (Abbreviation)
Metapneumovirus Avian metapneumovirus avian metapneumovirus (AMPV)
Human metapneumovirus human metapneumovirus (HMPV)
Orthopneumovirus Bovine orthopneumovirus bovine respiratory syncytial virus (BRSV)
Human orthopneumovirus human respiratory syncytial virus A2 (HRSV-A2)
human respiratory syncytial virus B1 (HRSV-B1)
Murine orthopneumovirusmurine pneumonia virus (MPV)

Related Research Articles

<i>Paramyxoviridae</i> Family of viruses

Paramyxoviridae is a family of negative-strand RNA viruses in the order Mononegavirales. Vertebrates serve as natural hosts. Diseases associated with this family include measles, mumps, and respiratory tract infections. The family has four subfamilies, 17 genera, and 78 species, three genera of which are unassigned to a subfamily.

<i>Filoviridae</i> Family of viruses in the order Mononegavirales

Filoviridae is a family of single-stranded negative-sense RNA viruses in the order Mononegavirales. Two members of the family that are commonly known are Ebola virus and Marburg virus. Both viruses, and some of their lesser known relatives, cause severe disease in humans and nonhuman primates in the form of viral hemorrhagic fevers.

<i>Henipavirus</i> Genus of RNA viruses

Henipavirus is a genus of negative-strand RNA viruses in the family Paramyxoviridae, order Mononegavirales containing six established species, and numerous others still under study. Henipaviruses are naturally harboured by several species of small mammals, notably pteropid fruit bats, microbats of several species, and shrews. Henipaviruses are characterised by long genomes and a wide host range. Their recent emergence as zoonotic pathogens capable of causing illness and death in domestic animals and humans is a cause of concern.

<i>Morbillivirus</i> Genus of viruses

Morbillivirus is a genus of viruses in the order Mononegavirales, in the family Paramyxoviridae. Humans, dogs, cats, cattle, seals, and cetaceans serve as natural hosts. This genus includes seven species. Diseases in humans associated with viruses classified in this genus include measles; in animals, they include acute febrile respiratory tract infection. In 2013, a wave of increased death among the Common bottlenose dolphin population was attributed to morbillivirus.

<i>Rhabdoviridae</i> Family of viruses in the order Mononegavirales

Rhabdoviridae is a family of negative-strand RNA viruses in the order Mononegavirales. Vertebrates, invertebrates, plants, fungi and protozoans serve as natural hosts. Diseases associated with member viruses include rabies encephalitis caused by the rabies virus, and flu-like symptoms in humans caused by vesiculoviruses. The name is derived from Ancient Greek rhabdos, meaning rod, referring to the shape of the viral particles. The family has 40 genera, most assigned to three subfamilies.

<i>Mononegavirales</i> Order of viruses

Mononegavirales is an order of negative-strand RNA viruses which have nonsegmented genomes. Some members that cause human disease in this order include Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. Important pathogens of nonhuman animals and plants are also in the group. The order includes eleven virus families: Artoviridae, Bornaviridae, Filoviridae, Lispiviridae, Mymonaviridae, Nyamiviridae, Paramyxoviridae, Pneumoviridae, Rhabdoviridae, Sunviridae, and Xinmoviridae.

<i>Human metapneumovirus</i> Species of virus

Human metapneumovirus is a negative-sense single-stranded RNA virus of the family Pneumoviridae and is closely related to the Avian metapneumovirus (AMPV) subgroup C. It was isolated for the first time in 2001 in the Netherlands by using the RAP-PCR technique for identification of unknown viruses growing in cultured cells. As of 2016, it was the second most common cause of acute respiratory tract illness in otherwise-healthy children under the age of 5 in large a US outpatient clinic.

<span class="mw-page-title-main">Rubella virus</span> Species of virus

Rubella virus (RuV) is the pathogenic agent of the disease rubella, transmitted only between humans via the respiratory route, and is the main cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy.

<span class="mw-page-title-main">Rabies virus</span> Species of virus

Rabies virus, scientific name Rabies lyssavirus, is a neurotropic virus that causes rabies in animals, including humans. Rabies transmission can occur through the saliva of animals and less commonly through contact with human saliva. Rabies lyssavirus, like many rhabdoviruses, has an extremely wide host range. In the wild it has been found infecting many mammalian species, while in the laboratory it has been found that birds can be infected, as well as cell cultures from mammals, birds, reptiles and insects. Rabies is reported in more than 150 countries and on all continents except Antarctica. The main burden of disease is reported in Asia and Africa, but some cases have been reported also in Europe in the past 10 years, especially in returning travellers.

<i>Bunyavirales</i> Order of RNA viruses

Bunyavirales is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class Ellioviricetes. The name Bunyavirales derives from Bunyamwera, where the original type species Bunyamwera orthobunyavirus was first discovered. Ellioviricetes is named in honor of late virologist Richard M. Elliott for his early work on bunyaviruses.

The genome and proteins of HIV (human immunodeficiency virus) have been the subject of extensive research since the discovery of the virus in 1983. "In the search for the causative agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus (HTLV), which was known at the time to affect the human immune system and cause certain leukemias. However, researchers at the Pasteur Institute in Paris isolated a previously unknown and genetically distinct retrovirus in patients with AIDS which was later named HIV." Each virion comprises a viral envelope and associated matrix enclosing a capsid, which itself encloses two copies of the single-stranded RNA genome and several enzymes. The discovery of the virus itself occurred two years following the report of the first major cases of AIDS-associated illnesses.

<i>Molluscum contagiosum virus</i> Species of virus

Molluscum contagiosum virus (MCV) is a species of DNA poxvirus that causes the human skin infection molluscum contagiosum. Molluscum contagiosum affects about 200,000 people a year, about 1% of all diagnosed skin diseases. Diagnosis is based on the size and shape of the skin lesions and can be confirmed with a biopsy, as the virus cannot be routinely cultured. Molluscum contagiosum virus is the only species in the genus Molluscipoxvirus. MCV is a member of the subfamily Chordopoxvirinae of family Poxviridae. Other commonly known viruses that reside in the subfamily Chordopoxvirinae are variola virus and monkeypox virus.

<i>Zaire ebolavirus</i> Species of virus affecting humans and animals

Zaire ebolavirus, more commonly known as Ebola virus, is one of six known species within the genus Ebolavirus. Four of the six known ebolaviruses, including EBOV, cause a severe and often fatal hemorrhagic fever in humans and other mammals, known as Ebola virus disease (EVD). Ebola virus has caused the majority of human deaths from EVD, and was the cause of the 2013–2016 epidemic in western Africa, which resulted in at least 28,646 suspected cases and 11,323 confirmed deaths.

Batai orthobunyavirus (BATV) is a RNA virus belonging to order Bunyavirales, genus Orthobunyavirus.

<i>Nyamiviridae</i> Family of viruses

Nyamiviridae is a family of negative-strand RNA viruses in the order Mononegavirales. Ecdysozoa and birds serve as natural hosts. The name is a portmanteau of Nyamanini Pan and Midway Atoll and the suffix -viridae used to denote a virus family. There are seven genera in this family.

Feline morbillivirus comes from the genus Morbillivirus, specifically influencing wild and domestic cats. The first report of a Feline morbillivirus outbreak occurred in Hong Kong in 2012. Approximately 10% of stray cats in Hong Kong and mainland China were reported to possess the virus at the time with additional infections found in Japan as well. 40% of cats tested in Japan were Fmo-PV positive and exhibited early symptoms of kidney failure. While the first cases of Feline morbillivirus were found in China, Hong Kong and Japan, the virus can also be found in Italy, Germany, and the United States. Feline morbillivirus exhibits a substantial amount of genetic diversity, yet cases in Japan and Hong Kong proved to have identical nucleotide sequences. It is also hypothesized that the morbillivirus has high adaptability due to its presence in multiple species. It is often found in dogs, cats, cattle, whales, dolphins, porpoises, and even humans. It likely originated from an ancestral version and underwent viral evolution to adapt to transmission in different species. Other common morbilliviruses include measles, rinderpest virus, canine distemper virus and peste des petits ruminants virus.

<i>Avian metaavulavirus 2</i> Species of virus

Avian metaavulavirus 2, formerly Avian paramyxovirus 2, is a species of virus belonging to the family Paramyxoviridae and genus Metaavulavirus. The virus is a negative strand RNA virus containing a monopartite genome. Avian metaavulavirus 2 is one of nine species belonging to the genus Metaavulavirus. The most common serotype of Avulavirinae is serotype 1, the cause of Newcastle disease (ND). Avian metaavulavirus 2 has been known to cause disease, specifically mild respiratory infections in domestic poultry, including turkeys and chickens, and has many economic effects on egg production and poultry industries. The virus was first isolated from a strain in Yucaipa, California in 1956. Since then, other isolates of the virus have been isolated worldwide.

Bat mumps orthorubulavirus, formerly Bat mumps rubulavirus (BMV), is a member of genus Orthorubulavirus, family Paramyxoviridae, and order Mononegavirales. Paramyxoviridae viruses were first isolated from bats using heminested PCR with degenerate primers. This process was then followed by Sanger sequencing. A specific location of this virus is not known because it was isolated from bats worldwide. Although multiple paramyxoviridae viruses have been isolated worldwide, BMV specifically has not been isolated thus far. However, BMV was detected in African fruit bats, but no infectious form has been isolated to date. It is known that BMV is transmitted through saliva in the respiratory system of bats. While the virus was considered its own species for a few years, phylogenetic analysis has since shown that it is a member of Mumps orthorubulavirus.

<i>Sepik virus</i> Mosquito transmitted virus endemic to Papua New Guinea

Sepik virus (SEPV) is an arthropod-borne virus (arbovirus) of the genus Flavivirus and family Flaviviridae. Flaviviridae is one of the most well characterized viral families, as it contains many well-known viruses that cause diseases that have become very prevalent in the world, like Dengue virus. The genus Flavivirus is one of the largest viral genera and encompasses over 50 viral species, including tick and mosquito borne viruses like Yellow fever virus and West Nile virus. Sepik virus is much less well known and has not been as well-classified as other viruses because it has not been known of for very long. Sepik virus was first isolated in 1966 from the mosquito Mansoniaseptempunctata, and it derives its name from the Sepik River area in Papua New Guinea, where it was first found. The geographic range of Sepik virus is limited to Papua New Guinea, due to its isolation.

Rio Negro virus is an alphavirus that was first isolated in Argentina in 1980. The virus was first called Ag80-663 but was renamed to Rio Negro virus in 2005. It is a former member of the Venezuelan equine encephalitis complex (VEEC), which are a group of alphaviruses in the Americas that have the potential to emerge and cause disease. Río Negro virus was recently reclassified as a distinct species. Closely related viruses include Mucambo virus and Everglades virus.

References

  1. 1 2 3 4 5 "ICTV Online (10th) Report".
  2. ↑ "Online Etymology Dictionary". www.etymonline.com. Retrieved 2016-12-14.
  3. ↑ "Online Etymology Dictionary". www.etymonline.com. Retrieved 2016-12-14.
  4. ↑ Afonso, Claudio L.; Amarasinghe, Gaya K.; Bányai, Krisztián; Bào, Yīmíng; Basler, Christopher F.; Bavari, Sina; Bejerman, Nicolás; Blasdell, Kim R.; Briand, François-Xavier (2016-08-01). "Taxonomy of the order Mononegavirales: update 2016". Archives of Virology. 161 (8): 2351–2360. doi:10.1007/s00705-016-2880-1. ISSN   1432-8798. PMC   4947412 . PMID   27216929.
  5. 1 2 3 4 5 6 "ViralZone: Pneumovirus". viralzone.expasy.org. Retrieved 2016-12-14.
  6. ↑ Gutsche, Irina; Desfosses, Ambroise; Effantin, Grégory; Ling, Wai Li; Haupt, Melina; Ruigrok, Rob W. H.; Sachse, Carsten; Schoehn, Guy (2015-04-16). "Near-atomic cryo-EM structure of the helical measles virus nucleocapsid". Science. 348 (6235): 704–7. Bibcode:2015Sci...348..704G. doi: 10.1126/science.aaa5137 . ISSN   0036-8075. PMID   25883315. S2CID   206634912.
  7. ↑ Kuhn, Jens H. (November 2015). "Elevation of the paramyxoviral subfamily Pneumovirinae to family status as family Pneumoviridae in the order Mononegavirales; and renaming of one pneumoviral genus" (PDF). ICTV. Archived from the original (PDF) on 2016-09-10. Retrieved 2016-12-14.
  8. 1 2 3 4 Stokes, H. L.; Easton, A. J.; Marriott, A. C. (2003-01-01). "Chimeric pneumovirus nucleocapsid (N) proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein". Journal of General Virology. 84 (10): 2679–2683. doi: 10.1099/vir.0.19370-0 . PMID   13679601.
  9. ↑ Renner, Max; Bertinelli, Mattia; Leyrat, Cédric; Paesen, Guido C.; Oliveira, Laura Freitas Saraiva de; Huiskonen, Juha T.; Grimes, Jonathan M. (2016-02-15). "Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein". eLife. 5: e12627. doi: 10.7554/eLife.12627 . ISSN   2050-084X. PMC   4798948 . PMID   26880565.
  10. ↑ Thomas., Leitner (2002-01-01). The Molecular Epidemiology of Human Viruses. Springer US. p. 330. OCLC   852790083.
  11. ↑ Leyrat, Cedric; Renner, Max; Harlos, Karl; Huiskonen, Juha T.; Grimes, Jonathan M. (2014-05-19). "Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae". eLife. 3: e02674. doi: 10.7554/eLife.02674 . ISSN   2050-084X. PMC   4051120 . PMID   24842877.
  12. ↑ Cheng, Xing; Park, HyunJung; Zhou, Helen; Jin, Hong (2005-11-15). "Overexpression of the M2-2 Protein of Respiratory Syncytial Virus Inhibits Viral Replication". Journal of Virology. 79 (22): 13943–13952. doi:10.1128/JVI.79.22.13943-13952.2005. ISSN   0022-538X. PMC   1280200 . PMID   16254330.
  13. 1 2 3 Melero, José A.; Mas, Vicente (2015-11-02). "The Pneumovirinae fusion (F) protein: A common target for vaccines and antivirals". Virus Research. Special Issue: Cell response to viral infection. 209: 128–135. doi:10.1016/j.virusres.2015.02.024. PMID   25738581.
  14. ↑ Graaf, Miranda de; Herfst, Sander; Aarbiou, Jamil; Burgers, Peter C.; Zaaraoui-Boutahar, Fatiha; Bijl, Maarten; IJcken, Wilfred van; Schrauwen, Eefje J. A.; Osterhaus, Albert D. M. E. (2013-03-06). "Small Hydrophobic Protein of Human Metapneumovirus Does Not Affect Virus Replication and Host Gene Expression In Vitro". PLOS ONE. 8 (3): e58572. Bibcode:2013PLoSO...858572D. doi: 10.1371/journal.pone.0058572 . ISSN   1932-6203. PMC   3590193 . PMID   23484037.
  15. ↑ Thammawat, Sutthiwan; Sadlon, Tania A.; Hallsworth, Peter G.; Gordon, David L. (2008-12-01). "Role of Cellular Glycosaminoglycans and Charged Regions of Viral G Protein in Human Metapneumovirus Infection". Journal of Virology. 82 (23): 11767–11774. doi:10.1128/JVI.01208-08. ISSN   0022-538X. PMC   2583676 . PMID   18786997.
  16. 1 2 Paesen, Guido C.; Collet, Axelle; Sallamand, Corinne; Debart, Françoise; Vasseur, Jean-Jacques; Canard, Bruno; Decroly, Etienne; Grimes, Jonathan M. (2015-11-09). "X-ray structure and activities of an essential Mononegavirales L-protein domain". Nature Communications. 6: 8749. Bibcode:2015NatCo...6.8749P. doi:10.1038/ncomms9749. ISSN   2041-1723. PMC   4659945 . PMID   26549102.
  17. ↑ Easton, Andrew J.; Domachowske, Joseph B.; Rosenberg, Helene F. (2017-05-01). "Animal Pneumoviruses: Molecular Genetics and Pathogenesis". Clinical Microbiology Reviews. 17 (2): 390–412. doi:10.1128/CMR.17.2.390-412.2004. ISSN   0893-8512. PMC   387412 . PMID   15084507.
  18. 1 2 3 Panda, Swagatika; Mohakud, Nirmal Kumar; Pena, Lindomar; Kumar, Subrat (2014). "Human metapneumovirus: review of an important respiratory pathogen". International Journal of Infectious Diseases. 25: 45–52. doi: 10.1016/j.ijid.2014.03.1394 . PMC   7110553 . PMID   24841931.
  19. ↑ "Pneumovirus". The Free Dictionary.
  20. ↑ "Learn About Human Metapneumovirus (hMPV)". American Lung Association. Retrieved 2016-05-13.
  21. ↑ "Wolters Kluwer Health - Article Landing Page". pt.wkhealth.com. Retrieved 2016-05-13.
  22. ↑ Bao, Xiaoyong; Liu, Tianshuang; Shan, Yichu; Li, Kui; Garofalo, Roberto P.; Casola, Antonella (2008-05-30). "Human Metapneumovirus Glycoprotein G Inhibits Innate Immune Responses". PLOS Pathog. 4 (5): e1000077. doi: 10.1371/journal.ppat.1000077 . ISSN   1553-7374. PMC   2386556 . PMID   18516301.
  23. ↑ Peiris, J.S. Malik; Tang, Wing-Hong; Chan, Kwok-Hung; Khong, Pek-Lan; Guan, Yi; Lau, Yu-Lung; Chiu, Susan S. (2003-06-01). "Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong". Emerging Infectious Diseases. 9 (6): 628–633. doi:10.3201/eid0906.030009. ISSN   1080-6040. PMC   3000155 . PMID   12781000.
  24. ↑ Amarasinghe, Gaya K.; Bào, Yīmíng; Basler, Christopher F.; Bavari, Sina; Beer, Martin; Bejerman, Nicolás; Blasdell, Kim R.; Bochnowski, Alisa; Briese, Thomas (2017-04-07). "Taxonomy of the order Mononegavirales: update 2017". Archives of Virology. 162 (8): 2493–2504. doi:10.1007/s00705-017-3311-7. ISSN   1432-8798. PMC   5831667 . PMID   28389807.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.