Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes.
Maclura pomifera, commonly known as the Osage orange, is a small deciduous tree or large shrub, native to the south-central United States. It typically grows about 8 to 15 metres (30–50 ft) tall. The distinctive fruit, a multiple fruit, is roughly spherical, bumpy, 8 to 15 centimetres (3–6 in) in diameter, and turns bright yellow-green in the fall. The fruits secrete a sticky white latex when cut or damaged. Despite the name "Osage orange", it is not related to the orange. It is a member of the mulberry family, Moraceae. Due to its latex secretions and woody pulp, the fruit is typically not eaten by humans and rarely by foraging animals. Ecologists Daniel H. Janzen and Paul S. Martin proposed in 1982 that the fruit of this species might be an example of what has come to be called an evolutionary anachronism—that is, a fruit coevolved with a large animal seed dispersal partner that is now extinct. This hypothesis is controversial.
Flavonoids are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans.
Gingerol ([6]-gingerol) is a phenolic phytochemical compound found in fresh ginger that activates heat receptors on the tongue. It is normally found as a pungent yellow oil in the ginger rhizome, but can also form a low-melting crystalline solid. This chemical compound is found in all members of the Zingiberaceae family and is high in concentrations in the grains of paradise as well as an African Ginger species.
Maclura is a genus of flowering plants in the mulberry family, Moraceae. It includes the inedible Osage orange, which is used as mosquito repellent and grown throughout the United States as a hedging plant. It is dioecious, with male and female flowers borne on separate plants.
Genistein (C15H10O5) is a naturally occurring compound that structurally belongs to a class of compounds known as isoflavones. It is described as an angiogenesis inhibitor and a phytoestrogen.
Ursolic acid, is a pentacyclic triterpenoid identified in the epicuticular waxes of apples as early as 1920 and widely found in the peels of fruits, as well as in herbs and spices like rosemary and thyme.
Ficus deltoidea, commonly known as mistletoe fig is a species of flowering plant in the family Moraceae, native to Southeast Asia, and widely naturalized in other parts of the world.
Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers. Its chemical formula was first described by Austrian chemist Josef Herzig in 1891.
Morin is a yellow chemical compound that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic), and from leaves of Psidium guajava (common guava). In a preclinical in vitro study, morin was found to be a weak inhibitor of fatty acid synthase with an IC50 of 2.33 μM. Morin was also found to inhibit amyloid formation by islet amyloid polypeptide (or amylin) and disaggregate amyloid fibers.
Dihydromorin is a flavanonol, a type of flavonoid. It can be found in plants of the family Moraceae including Morus nigra, in Morus alba, Maclura pomifera, in the jackfruit and in Artocarpus dadah.
Ichnocarpus frutescens is a species of flowering plant in the dogbane family Apocynaceae, known by the English common name black creeper. It is native to much of China, India, Southeast Asia, and northern Australia.
Syringin is a natural chemical compound first isolated from the bark of lilac by Meillet in 1841. It has since been found to be distributed widely throughout many types of plants. It is also called eleutheroside B, and is found in Eleutherococcus senticosus. It is also found in dandelion coffee. Syringin may potentially have antidiabetic effects.
In molecular biology, the jacalin-like lectin domain is a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B-cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.
Pluchea indica is a species of flowering plant in the aster family, Asteraceae. Its common names include Indian camphorweed, Indian fleabane, and Indian pluchea. It is native to parts of Asia and Australia, and it is widespread in the Pacific Islands as an introduced and often invasive species.
Methyl caffeate is an ester of caffeic acid, a naturally occurring phenolic compound. It is an α-glucosidase inhibitor. Its physical form is a powder.
Helicteres isora, sometimes called the Indian screw tree, is a small tree or large shrub found in southern Asia and northern Oceania. It is usually assigned to the family Malvaceae, but it is sometimes assigned to the family Sterculiaceae. The red flowers are pollinated mainly by sunbirds, butterflies, and Hymenoptera. In the 19th century fibers from the bark were used to make rope and sacks, although nowadays the tree is harvested for the fruits and roots which are used in folk medicine.
Saururus chinensis, commonly known as Asian lizard's tail, is an herb that grows in low, damp places to more than 1 meter high, endemic to China, India, Japan, Korea, Philippines, and Vietnam. Its leaves are green, papery, ribbed, densely glandular, and ovate to ovate-lanceolate, and (4-)10-20 × (2-)5-10 cm in size. Each flower spike resembles a lizard's tail.
Geniposide, the glycoside form of genipin, is a bioactive iridoid glycoside that is found in a wide variety of medicinal herbs, such as Gardenia jasminoides (fruits) . Geniposide shows several pharmacological effects including neuroprotective, antidiabetic, hepatoprotective, anti-inflammatory, analgesic, antidepressant-like, cardioprotective, antioxidant, immune-regulatory, antithrombotic and antitumoral activity. These pharmacology benefits arise through the modulating action of geniposide on several proteins and genes that are associated with inflammatory and oxidative stress processes.
Sekikaic acid is an organic compound in the structural class of chemicals known as depsides. It is found in some lichens. First isolated from Ramalina sekika, it is a fairly common lichen product in Ramalina and Cladonia, both genera of lichen-forming fungi. The species epithet of the powdery lichen Lepraria sekikaica refers to the presence of this substance—a rarity in genus Lepraria.
