RABAC1

RABAC1
Identifiers
Aliases	RABAC1 , PRA1, PRAF1, YIP3, Rab acceptor 1
External IDs	OMIM: 604925 MGI: 1201692 HomoloGene: 38182 GeneCards: RABAC1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,959,321 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,672,179 bp
RNA expression pattern
	Top expressed in
	thoracic aorta; ; ascending aorta; ; pituitary gland; ; anterior pituitary; ; left coronary artery; ; stromal cell of endometrium; ; canal of the cervix; ; hypothalamus; ; popliteal artery; ; right coronary artery;
	Top expressed in
	seminal vesicula; ; parotid gland; ; right lung; ; right lung lobe; ; entorhinal cortex; ; interventricular septum; ; extensor digitorum longus muscle; ; olfactory epithelium; ; calvaria; ; lip;
	More reference expression data
	More reference expression data
Orthologs
	10567
	14470
	ENSG00000105404
	ENSMUSG00000003380
	Q9UI14
	Q9Z0S9
	NM_006423
	NM_010261
	NP_006414
	NP_034391
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

RABAC1 is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1.^[5]^[6]^[7] It is highly conserved in eukaryotes.^[5] The protein is localized to Golgi^[8] and late endosomes,^[9] where it plays a role in vesicular trafficking, lipid transport and cell migration.^[10]

Interactions

RABAC1 has been shown to interact with numerous prenylated members of the Rab GTPase family^[5]^[11]^[12] and VAMP2.^[12]

Related Research Articles

Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene.

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.

Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.

Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene.

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.

Ras-related protein Rab-2A is a protein that in humans is encoded by the RAB2A gene.

Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two paralogs of the Ral protein, the other being RalA, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene. PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

NCK-interacting protein with SH3 domain is a protein that in humans is encoded by the NCKIPSD gene.

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.

Nuclear prelamin A recognition factor, also known as NARF, is a protein which in humans is encoded by the NARF gene.

Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene. RAB5C belongs to the Ras-related protein family.

Differentially expressed in FDCP 6 homolog is a protein that in humans is encoded by the DEF6 gene.

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105404 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003380 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (May 1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
↑ Hutt DM, Da-Silva LF, Chang LH, Prosser DC, Ngsee JK (Jun 2000). "PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1". The Journal of Biological Chemistry. 275 (24): 18511–9. doi: 10.1074/jbc.M909309199 . PMID 10751420.
↑ "Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)".
↑ Abdul-Ghani M, Gougeon PY, Prosser DC, Da-Silva LF, Ngsee JK (Mar 2001). "PRA isoforms are targeted to distinct membrane compartments". The Journal of Biological Chemistry. 276 (9): 6225–33. doi: 10.1074/jbc.M009073200 . PMID 11096102.
↑ Sivars U, Aivazian D, Pfeffer SR (Oct 2003). "Yip3 catalyses the dissociation of endosomal Rab-GDI complexes". Nature. 425 (6960): 856–9. Bibcode:2003Natur.425..856S. doi:10.1038/nature02057. PMID 14574414. S2CID 4421009.
↑ Liu HP, Wu CC, Kao HY, Huang YC, Liang Y, Chen CC, Yu JS, Chang YS (Mar 2011). "Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration". Molecular & Cellular Proteomics. 10 (3): M900641–MCP200. doi:10.1074/mcp.M900641-MCP200. PMC 3047168 . PMID 20592422.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
1 2 Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi: 10.1074/jbc.272.43.26991 . PMID 9341137.

Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi: 10.1074/jbc.272.43.26991 . PMID 9341137.
Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (Jan 2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron. 25 (1): 203–14. doi: 10.1016/S0896-6273(00)80883-1 . PMID 10707984.
Figueroa C, Taylor J, Vojtek AB (Jul 2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". The Journal of Biological Chemistry. 276 (30): 28219–25. doi: 10.1074/jbc.M101763200 . PMID 11335720.
Bucci C, De Gregorio L, Bruni CB (Aug 2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochemical and Biophysical Research Communications. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
Evans DT, Tillman KC, Desrosiers RC (Jan 2002). "Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor". Journal of Virology. 76 (1): 327–37. doi:10.1128/JVI.76.1.327-337.2002. PMC 135700 . PMID 11739697.
Blancou P, Evans DT, Desrosiers RC (Jun 2005). "PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation". The Journal of General Virology. 86 (Pt 6): 1785–90. doi: 10.1099/vir.0.80873-0 . PMID 15914857.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi: 10.1016/j.cell.2005.08.029 . hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Fo CS, Coleman CS, Wallick CJ, Vine AL, Bachmann AS (Apr 2006). "Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2)". Gene. 371 (1): 154–65. doi:10.1016/j.gene.2005.12.009. PMID 16481131.
Liu HP, Wu CC, Chang YS (Sep 2006). "PRA1 promotes the intracellular trafficking and NF-kappaB signaling of EBV latent membrane protein 1". The EMBO Journal. 25 (17): 4120–30. doi:10.1038/sj.emboj.7601282. PMC 1560356 . PMID 16917502.
Kim JT, Cho MY, Choi SC, Kim JW, Chae SK, Yoon DY, Kim JW, Lim JS (Oct 2006). "Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin". Biochemical and Biophysical Research Communications. 349 (1): 200–8. doi:10.1016/j.bbrc.2006.08.026. PMID 16930546.
Dickison VM, Richmond AM, Abu Irqeba A, Martak JG, Hoge SC, Brooks MJ, Othman MI, Khanna R, Mears AJ, Chowdhury AY, Swaroop A, Ogilvie JM (2012). "A role for prenylated rab acceptor 1 in vertebrate photoreceptor development". BMC Neuroscience. 13: 152. doi: 10.1186/1471-2202-13-152 . PMC 3576285 . PMID 23241222.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105404 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003380 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10329441-5] 1 2 3 Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (May 1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.

[pmid10751420-6] Hutt DM, Da-Silva LF, Chang LH, Prosser DC, Ngsee JK (Jun 2000). "PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1". The Journal of Biological Chemistry. 275 (24): 18511–9. doi: 10.1074/jbc.M909309199 . PMID 10751420.

[entrez-7] "Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)".

[8] Abdul-Ghani M, Gougeon PY, Prosser DC, Da-Silva LF, Ngsee JK (Mar 2001). "PRA isoforms are targeted to distinct membrane compartments". The Journal of Biological Chemistry. 276 (9): 6225–33. doi: 10.1074/jbc.M009073200 . PMID 11096102.

[9] Sivars U, Aivazian D, Pfeffer SR (Oct 2003). "Yip3 catalyses the dissociation of endosomal Rab-GDI complexes". Nature. 425 (6960): 856–9. Bibcode:2003Natur.425..856S. doi:10.1038/nature02057. PMID 14574414. S2CID 4421009.

[10] Liu HP, Wu CC, Kao HY, Huang YC, Liang Y, Chen CC, Yu JS, Chang YS (Mar 2011). "Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration". Molecular & Cellular Proteomics. 10 (3): M900641–MCP200. doi:10.1074/mcp.M900641-MCP200. PMC 3047168 . PMID 20592422.

[pmid16189514-11] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid9341137-12] 1 2 Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi: 10.1074/jbc.272.43.26991 . PMID 9341137.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

RABAC1

Contents

Interactions

Related Research Articles

References

Further reading