RAI14

RAI14
Identifiers
Aliases	RAI14 , NORPEG, RAI13, retinoic acid induced 14
External IDs	OMIM: 606586; MGI: 1922896; HomoloGene: 9199; GeneCards: RAI14; OMA:RAI14 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p13.2 Start 34,656,328 bp [1] End 34,832,612 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 A1 Start 10,569,055 bp [2] End 10,714,710 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium visceral pleura ventricular zone smooth muscle tissue placenta decidua glomerulus amniotic fluid metanephric glomerulus myometrium Top expressed in renal corpuscle lumbar spinal ganglion ciliary body left lung lobe iris hair follicle endothelial cell of lymphatic vessel ureter maxillary prominence sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cell cortex cytoskeleton nucleus fibrillar center cytoplasm cytosol cell junction Biological process spermatogenesis cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26064 75646 Ensembl ENSG00000039560 ENSMUSG00000022246 UniProt Q9P0K7 Q9EP71 RefSeq (mRNA) NM_001145520 NM_001145521 NM_001145522 NM_001145523 NM_001145525 NM_015577 NM_001166408 NM_030690 NM_001356534 RefSeq (protein) NP_001138992 NP_001138993 NP_001138994 NP_001138995 NP_001138997 NP_056392 NP_001159880 NP_109615 NP_001343463 Location (UCSC) Chr 5: 34.66 – 34.83 Mb Chr 15: 10.57 – 10.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ankycorbin is a protein that in humans is encoded by the RAI14 gene. ^{[5] [6]} Ankycorbin has been associated with the cortical actin cytoskeleton structures in terminal web, cell-cell adhesion sites as well as stress fibres. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000039560 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022246 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kutty RK, Kutty G, Samuel W, Duncan T, Bridges CC, El-Sherbeeny A, Nagineni CN, Smith SB, Wiggert B (May 2001). "Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid". J Biol Chem. 276 (4): 2831–40. doi: 10.1074/jbc.M007421200 . PMID   11042181.
6. "Entrez Gene: RAI14 retinoic acid induced 14".
7. Peng YF, Mandai K, Sakisaka T, Okabe N, Yamamoto Y, Yokoyama S, Mizoguchi A, Shiozaki H, Monden M, Takai Y (December 2000). "Ankycorbin: a novel actin cytoskeleton-associated protein". Genes Cells. 5 (12): 1001–8. doi:10.1046/j.1365-2443.2000.00381.x. PMID   11168586. S2CID   19149724.

Further reading

• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Yuan W, Zheng Y, Huo R, Lu L, Huang XY, Yin LL, Li JM, Zhou ZM, Sha JH (September 2005). "Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes". Asian J. Androl. 7 (3): 277–88. doi: 10.1111/j.1745-7262.2005.00040.x . PMID   16110356.
• Kutty RK, Chen S, Samuel W, Vijayasarathy C, Duncan T, Tsai JY, Fariss RN, Carper D, Jaworski C, Wiggert B (July 2006). "Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein". Biochem. Biophys. Res. Commun. 345 (4): 1333–41. doi:10.1016/j.bbrc.2006.04.184. PMID   16729964.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.